Home Cart Sign in  
Chemical Structure| 170850-75-6 Chemical Structure| 170850-75-6

Structure of Boc-Hyp-OtBu
CAS No.: 170850-75-6

Chemical Structure| 170850-75-6

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

DE Stock

US Stock

Asia Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 170850-75-6 ]

CAS No. :170850-75-6
Formula : C14H25NO5
M.W : 287.35
SMILES Code : O=C(N1[C@H](C(OC(C)(C)C)=O)C[C@@H](O)C1)OC(C)(C)C
MDL No. :MFCD01318729
InChI Key :OXHIVNUWGSCHBD-ZJUUUORDSA-N
Pubchem ID :7408710

Safety of [ 170850-75-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 170850-75-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 170850-75-6 ]

[ 170850-75-6 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 7635-54-3 ]
  • [ 170850-75-6 ]
  • [ 865303-09-9 ]
  • 2
  • [ 21286-54-4 ]
  • [ 170850-75-6 ]
  • [ 865303-05-5 ]
  • 3
  • [ 40350-83-2 ]
  • [ 170850-75-6 ]
  • 4
  • [ 42017-89-0 ]
  • [ 170850-75-6 ]
  • [ 852056-06-5 ]
YieldReaction ConditionsOperation in experiment
63% With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20℃; for 96h; L-hydroxyproline-<strong>[42017-89-0]fenofibric acid</strong> ester To a mixture of <strong>[42017-89-0]fenofibric acid</strong> (24. 9 g, 78.1 mmol), N-carbobenzyloxy-L- hydroxyproline t-butyl ester (Boc-Hyp-OtBu, 20. 4 g, 71.0 mmole, prepared in accordance with the procedure in the literature), EDC (16.3 g, 85.2 mmol), and DMAP (1.04 g, 8.52 mmol) cooled in an ice-water bath was added anhydrous dichloromethane (200 mL) dropwise. After the addition was complete, the ice bath was removed and the reaction mixture was stirred under an argon atmosphere at room temperature for 20 hours. After 20 hours, additional EDC (1.63 g, 8.52 mmol) was added and the experiment was allowed to stir over the weekend at room temperature under an argon atmosphere. After 4 days the solution was washed with water (200 mL) and brine (200 mL). After drying over sodium sulfate and filtration, the solution was concentrated under reduced pressure. The remaining yellow oil (49.4 g) was purified by column chromatography on silica gel (500 g, 0.035-0. 070 mm, 6 nm pore diameter), eluting with heptane/ethyl acetate (2: 1). After concentration of the product containing fractions under reduced pressure and drying under high vacuum until the weight was constant, the experiment produced the protected L-hydroxyproline-<strong>[42017-89-0]fenofibric acid</strong> ester SPIB0020301 (26.4 g, 63% yield) as a colorless oil. 'H NMR (300 MHz, CDC13): 8 = 7.76 (2H, d, J= 8. 1 Hz), 7.73 (2H, d, J= 8.1 Hz), 7.46 (2H, d, J= 8. 1 Hz), 6. 84 (2H, d, J= 8. 1 Hz), 5.32 (1H, m), 4.13 (0. 38H, t, J= 7. 8 Hz), 4.00 (0.62H, t, J= 7. 8 Hz), 3.67 (1.62H, m), 3.46 (0. 38H, d, J=12. 6 Hz), 2.29 (1H, m), 2.15 (1H, m), 1.68 (3H, s), 1.66 (3H, s), 1.44-1. 38 (18H, m). '3C NMR (75 MHz, CDC13) : 8 193. 88, 172. 98, 171.14, 159.25, 153.48, 138. 23, 136.16, 131.99, 131.08, 130.36, 128. 44,117. 03,116. 91,81. 48,80. 32,80. 20,79. 19, 74.03, 73.26, 58. 23,51. 88,51. 58,36. 33,35. 31,31. 92,28. 29, 28. 00,25. 89,24. 95
  • 5
  • [ 42017-89-0 ]
  • [ 170850-75-6 ]
  • [ 852056-09-8 ]
 

Historical Records

Technical Information

Categories