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Structure of (1S)-(+)-Menthyl chloroformate
CAS No.: 7635-54-3
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
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Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
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CAS No. : | 7635-54-3 |
Formula : | C11H19ClO2 |
M.W : | 218.72 |
SMILES Code : | O=C(Cl)O[C@@H]1[C@@H](C(C)C)CC[C@H](C)C1 |
MDL No. : | MFCD00134483 |
InChI Key : | KIUPCUCGVCGPPA-AEJSXWLSSA-N |
Pubchem ID : | 2733329 |
GHS Pictogram: |
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Signal Word: | Danger |
Hazard Statements: | H314-H331 |
Precautionary Statements: | P261-P280-P305+P351+P338-P310 |
Class: | 6.1(8) |
UN#: | 3277 |
Packing Group: | Ⅱ |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99% | With pyridine; In dichloromethane; at -5 - 25℃; for 13h; | General procedure: In a jacketed reactor equipped with a mechanical stirrer, a thermometer, a constant pressure dropping funnel and an exhaust gas absorber,Add 7L dichloromethane, the first reaction phase, temperature -5 C,780 g (5 mol) of L-menthol and 1187 g (4 mol) of triphosgene were added in portions and sufficiently stirred to dissolve them.-5 CDrop under the drop1215 g (12mo 1) triethylamine in methylene chloride (1.8 L) was added dropwise over 1 to 2 h,Insulation reaction 3h after the natural temperature rise to the second reaction stage, temperature control 25 C, stirring about 10h.After completion of the reaction, the reaction mixture was separated by filtration under filtration, and the mother liquor was washed successively with 3 L of water, 3 L of dilute hydrochloric acid (5%), 0.5 L of sodium carbonate (5%) and 0.5 L of saturated brine ,After drying over anhydrous sodium sulfate, the solvent was removed by steaming and distilled under reduced pressure to collect 108 to 109 C / 1 ImmHg fraction,1063 g of a colorless liquid was obtained in a yield of 97.2%. |