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Quality Control of (1S)-(+)-Menthyl chloroformate Purity: 97% SDS Specification

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Product Details of (1S)-(+)-Menthyl chloroformate

CAS No. :	7635-54-3
Formula :	C₁₁H₁₉ClO₂
M.W :	218.72
SMILES Code :	O=C(Cl)O[C@@H]1[C@@H](C(C)C)CC[C@H](C)C1
MDL No. :	MFCD00134483
InChI Key :	KIUPCUCGVCGPPA-AEJSXWLSSA-N
Pubchem ID :	2733329

Safety of (1S)-(+)-Menthyl chloroformate

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H314-H331
Precautionary Statements:	P261-P280-P305+P351+P338-P310
Class:	6.1(8)
UN#:	3277
Packing Group:	Ⅱ

Application In Synthesis of (1S)-(+)-Menthyl chloroformate

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 7635-54-3 ]

[ 7635-54-3 ] Synthesis Path-Downstream 1~54

1
[ 135-16-0 ]
[ 7635-54-3 ]
(S)-2-(4-[2-Amino-5-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyloxycarbonyl)-4-oxo-3,4,5,6,7,8-hexahydro-pteridin-6-ylmethyl]-amino}-benzoylamino)-pentanedioic acid [ No CAS ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1993,p. 871 - 876.

2
[ 620-08-6 ]
[ 7635-54-3 ]
1-((1S,2R,5S)-2-Isopropyl-5-methyl-cyclohexyloxycarbonyl)-4-methoxy-pyridinium; chloride [ No CAS ]

References: [1]Journal of Organic Chemistry,1990,vol. 55,p. 2574 - 2576.

3
[ 75-44-5 ]
[ 15356-60-2 ]
[ 7635-54-3 ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1995,p. 1945 - 1950.
[2]Tetrahedron Letters,1985,vol. 26,p. 5433 - 5436.

4
[ 22191-05-5 ]
[ 7635-54-3 ]
(R)-2-((1S,2R,5S)-2-Isopropyl-5-methyl-cyclohexyloxycarbonyloxy)-hexanedioic acid dimethyl ester [ No CAS ]
(S)-2-((1S,2R,5S)-2-Isopropyl-5-methyl-cyclohexyloxycarbonyloxy)-hexanedioic acid dimethyl ester [ No CAS ]

References: [1]Journal of the American Chemical Society,1980,vol. 102,p. 1435 - 1436.

5
[ 7635-54-3 ]
[ 151-50-8 ]
[ 104461-84-9 ]

References: [1]Tetrahedron Letters,1985,vol. 26,p. 5433 - 5436.

6
[ 7635-54-3 ]
[ 78037-99-7 ]
(6E,8Z,11Z,14Z)-(S)-5-((1S,2R,5S)-2-Isopropyl-5-methyl-cyclohexyloxycarbonyloxy)-icosa-6,8,11,14-tetraenoic acid methyl ester [ No CAS ]

References: [1]Journal of the American Chemical Society,1980,vol. 102,p. 1435 - 1436.

7
[ 7635-54-3 ]
[ 112266-45-2 ]
1-((1S,2R,5S)-2-Isopropyl-5-methyl-cyclohexyloxycarbonyl)-4-methoxy-3-trimethylsilanyl-pyridinium; chloride [ No CAS ]

References: [1]Journal of Organic Chemistry,1990,vol. 55,p. 2574 - 2576.

8
[ 7635-54-3 ]
[ 126378-42-5 ]
[ 135365-65-0 ]

References: [1]Journal of Organic Chemistry,1990,vol. 55,p. 2574 - 2576.

9
[ 7635-54-3 ]
[ 100-47-0 ]
N-(r-1,t-2,c-5-2-Isopropyl-5-methylcyclohexyl)benzamide [ No CAS ]
N-<1-Methyl-1-(4-methylcyclohexyl)ethyl>benzamide [ No CAS ]

References: [1]Synthesis,1993,p. 426 - 432.

10
[ 7635-54-3 ]
[ 170940-99-5 ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1995,p. 1945 - 1950.

11
[ 102555-71-5 ]
[ 7635-54-3 ]
Thiocarbonic acid O-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl) ester S-[2'-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyloxycarbonylsulfanyl)-[1,1']binaphthalenyl-2-yl] ester [ No CAS ]
Thiocarbonic acid O-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl) ester S-[2'-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyloxycarbonylsulfanyl)-[1,1']binaphthalenyl-2-yl] ester [ No CAS ]

References: [1]Journal of Organic Chemistry,1995,vol. 60,p. 6599 - 6601.
[2]Journal of Organic Chemistry,1995,vol. 60,p. 6599 - 6601.

12
[ 7635-54-3 ]
[ 602-09-5 ]
Carbonic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester 2'-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyloxycarbonyloxy)-[1,1']binaphthalenyl-2-yl ester [ No CAS ]
Carbonic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester 2'-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyloxycarbonyloxy)-[1,1']binaphthalenyl-2-yl ester [ No CAS ]

References: [1]Journal of Organic Chemistry,1995,vol. 60,p. 6599 - 6601.
[2]Journal of Organic Chemistry,1995,vol. 60,p. 6599 - 6601.

13
[ 7635-54-3 ]
[ 156286-12-3 ]
C₇₁H₁₉NO₂ [ No CAS ]

References: [1]Tetrahedron Letters,1996,vol. 37,p. 4683 - 4684.

14
[ 7635-54-3 ]
[ 57182-15-7 ]
(3R,4S)-4-(2,6-Dimethyl-phenylamino)-2,2,5,5-tetramethyl-hexan-3-ol [ No CAS ]
2-(2,6-Dimethyl-phenylamino)-3,3-dimethyl-butyric acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester [ No CAS ]

References: [1]Tetrahedron,1998,vol. 54,p. 12007 - 12028.

15
[ 7635-54-3 ]
(3aR,4R,5R,5aS,8aR,8bR)-5-Benzyloxy-2,2,7,7-tetramethyl-hexahydro-benzo[1,2-d;3,4-d']bis[1,3]dioxol-4-ol [ No CAS ]
[ 207131-20-2 ]
Carbonic acid (3aS,4R,5S,5aS,8aR,8bS)-5-benzyloxy-2,2,7,7-tetramethyl-hexahydro-benzo[1,2-d;3,4-d']bis[1,3]dioxol-4-yl ester (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester [ No CAS ]

References: [1]Carbohydrate Research,1997,vol. 305,p. 171 - 179.
[2]Carbohydrate Research,1997,vol. 305,p. 171 - 179.

16
[ 7635-54-3 ]
[ 230309-18-9 ]
3-methoxycarbonyl-4-phenylpiperidine-1-carboxylic acid menthyl ester [ No CAS ]

References: [1]Tetrahedron,2001,vol. 57,p. 8939 - 8949.
[2]Tetrahedron Letters,1999,vol. 40,p. 4231 - 4234.

17
[ 5724-81-2 ]
[ 7635-54-3 ]
2,3-Dihydro-pyrrole-1-carboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester [ No CAS ]

References: [1]Tetrahedron Letters,1999,vol. 40,p. 7735 - 7738.

18
[ 32315-10-9 ]
[ 15356-60-2 ]
[ 7635-54-3 ]

Yield	Reaction Conditions	Operation in experiment
99%	With pyridine; In dichloromethane; at -5 - 25℃; for 13h;	General procedure: In a jacketed reactor equipped with a mechanical stirrer, a thermometer, a constant pressure dropping funnel and an exhaust gas absorber,Add 7L dichloromethane, the first reaction phase, temperature -5 C,780 g (5 mol) of L-menthol and 1187 g (4 mol) of triphosgene were added in portions and sufficiently stirred to dissolve them.-5 CDrop under the drop1215 g (12mo 1) triethylamine in methylene chloride (1.8 L) was added dropwise over 1 to 2 h,Insulation reaction 3h after the natural temperature rise to the second reaction stage, temperature control 25 C, stirring about 10h.After completion of the reaction, the reaction mixture was separated by filtration under filtration, and the mother liquor was washed successively with 3 L of water, 3 L of dilute hydrochloric acid (5%), 0.5 L of sodium carbonate (5%) and 0.5 L of saturated brine ,After drying over anhydrous sodium sulfate, the solvent was removed by steaming and distilled under reduced pressure to collect 108 to 109 C / 1 ImmHg fraction,1063 g of a colorless liquid was obtained in a yield of 97.2%.

References: [1]Patent: CN106045802,2016,A .Location in patent: Paragraph 0025; 0032-0033.
[2]Tetrahedron Letters,1999,vol. 40,p. 7735 - 7738.

19
[ 7635-54-3 ]
[ 121-44-8 ]
[ 250716-74-6 ]
N,N-diethyl (-)-(1R)-menthyl carbamate [ No CAS ]
Carbonic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester 8'-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyloxycarbonyloxy)-2,2'-dimethyl-[1,1']binaphthalenyl-8-yl ester [ No CAS ]

References: [1]Journal of Organic Chemistry,1999,vol. 64,p. 7921 - 7928.

20
[ 110-91-8 ]
[ 7635-54-3 ]
[ 333-20-0 ]
[ 331823-17-7 ]

References: [1]Journal of the Chemical Society, Dalton Transactions,2000,p. 4579 - 4586.

21
[ 7635-54-3 ]
[ 333-20-0 ]
[ 109-89-7 ]
[ 331823-15-5 ]

References: [1]Journal of the Chemical Society, Dalton Transactions,2000,p. 4579 - 4586.

22
[ 7635-54-3 ]
[ 494-52-0 ]
(2'S)-[(1S,2R,5S)-menthoxycarbonyl]anabasine [ No CAS ]

References: [1]Journal of Chemical Ecology,2001,vol. 27,p. 945 - 952.

23
[ 7635-54-3 ]
[ 13078-04-1 ]
(2'S)-[(1S,2R,5S)-menthoxycarbonyl]anabasine [ No CAS ]
(2'R)-[(1S,2R,5S)-menthoxycarbonyl]anabasine [ No CAS ]

References: [1]Journal of Chemical Ecology,2001,vol. 27,p. 945 - 952.

24
[ 7635-54-3 ]
[ 1049019-27-3 ]
(Z)-(-)-menthyl 5-oxo-2-phenyloxazol-4-methylenecarbonate [ No CAS ]

References: [1]Journal of Organic Chemistry,2001,vol. 66,p. 6299 - 6304.

25
[ 7635-54-3 ]
[ 259253-00-4 ]
Ethanesulfonic acid 5-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyloxycarbonylamino)-1,3-dioxo-1,3-dihydro-isoindol-2-yl ester [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2001,vol. 9,p. 637 - 645.

26
[ 7635-54-3 ]
cis-2-(hydroxymethyl)-5-(N⁴-acetylcytosin-1'-yl)-1,3-oxathiolane [ No CAS ]
Carbonic acid (2S,5R)-5-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-[1,3]oxathiolan-2-ylmethyl ester (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester [ No CAS ]
Carbonic acid (2R,5S)-5-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-[1,3]oxathiolan-2-ylmethyl ester (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester [ No CAS ]

References: [1]Synthetic Communications,2002,vol. 32,p. 2355 - 2359.

27
[ 7635-54-3 ]
(S)-tert-butyl(methyl)phosphine-borane [ No CAS ]
t-butyl[(1S)-menthyloxycarbonyl]methylphosphine-borane [ No CAS ]

References: [1]Bulletin of the Chemical Society of Japan,2002,vol. 75,p. 1359 - 1365.

28
[ 7635-54-3 ]
t-butylphosphine-borane [ No CAS ]
C₂₆H₅₀BO₄P [ No CAS ]

References: [1]Bulletin of the Chemical Society of Japan,2002,vol. 75,p. 1359 - 1365.

29
[ 7635-54-3 ]
[ 475273-53-1 ]
Carbonic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester 3'-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyloxycarbonyloxy)-9H,9'H-[4,4']bicarbazolyl-3-yl ester [ No CAS ]
Carbonic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester 3'-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyloxycarbonyloxy)-9H,9'H-[4,4']bicarbazolyl-3-yl ester [ No CAS ]

References: [1]European Journal of Organic Chemistry,2002,p. 1952 - 1955.

30
[ 7635-54-3 ]
(S)-(S)-1-(Tetrahydro-furan-2-yl)-tridecan-1-ol [ No CAS ]
[ 612084-67-0 ]
Carbonic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester (S)-(R)-1-(tetrahydro-furan-2-yl)-tridecyl ester [ No CAS ]

References: [1]Journal of Organic Chemistry,2003,vol. 68,p. 7548 - 7550.

31
[ 7635-54-3 ]
[ 849340-81-4 ]
(2-Iodo-benzyl)-prop-2-ynyl-carbamic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester [ No CAS ]

References: [1]Organic Letters,2005,vol. 7,p. 775 - 778.

32
[ 863491-46-7 ]
[ 7635-54-3 ]
[ 874304-95-7 ]

References: [1]Tetrahedron Asymmetry,2005,vol. 16,p. 3536 - 3561.

33
[ 863491-46-7 ]
[ 7635-54-3 ]
2,6-bis-(1-((1S,2R,5S)-2-isopropyl-5-methylcyclohexyloxycarbonyl)-[4R,5R]-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl)-pyridine [ No CAS ]

References: [1]Organic Letters,2005,vol. 7,p. 3393 - 3396.
[2]Tetrahedron Asymmetry,2005,vol. 16,p. 3536 - 3561.

34
1-((4R,5R)-4,5-dihydro-2-(6-((4R,5R)-4,5-dihydro-4,5-diphenyl-1H-imidazol-2-yl)pyridin-2-yl)-4,5-diphenylimidazol-1-yl)(mesityl)methanone [ No CAS ]
[ 7635-54-3 ]
2-(1-(2,4,6-trimethyl-benzoyl)-[4R,5R]-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl)-6-(1-((1S,2R,5S)-2-iso-propyl-5-methylcyclohexyl-3-oxycarbonyl)-[4R,5R]-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl)pyridine [ No CAS ]

References: [1]Tetrahedron Asymmetry,2005,vol. 16,p. 3536 - 3561.

35
[ 7635-54-3 ]
[ 275822-20-3 ]
Carbonic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester (1S,2S)-2-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyloxycarbonyloxy)-1,2-bis-(4-methoxy-phenyl)-acenaphthen-1-yl ester [ No CAS ]
Carbonic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester (1R,2R)-2-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyloxycarbonyloxy)-1,2-bis-(4-methoxy-phenyl)-acenaphthen-1-yl ester [ No CAS ]

References: [1]Journal of Organic Chemistry,2005,vol. 70,p. 5592 - 5598.

36
[ 7635-54-3 ]
[ 170850-75-6 ]
[ 865303-09-9 ]

References: [1]Tetrahedron,2005,vol. 61,p. 8669 - 8676.

37
[ 7635-54-3 ]
[ 762203-98-5 ]
((1S,2S)-2-Methyl-1-morpholin-4-ylmethyl-butyl)-carbamic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester [ No CAS ]

References: [1]Journal of Organic Chemistry,2005,vol. 70,p. 8835 - 8840.

38
[ 7635-54-3 ]
[ 100-46-9 ]
[ 683247-05-4 ]

References: [1]Organic and Biomolecular Chemistry,2005,vol. 3,p. 2741 - 2749.

39
[ 7635-54-3 ]
[ 914288-77-0 ]
Carbonic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester 7'-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyloxycarbonyloxy)-[8,8']biquinolinyl-7-yl ester [ No CAS ]

References: [1]Journal of Organic Chemistry,2006,vol. 71,p. 8212 - 8218.

40
[ 119-65-3 ]
[ 7677-24-9 ]
[ 7635-54-3 ]
[ 946834-57-7 ]

References: [1]Journal of Organic Chemistry,2007,vol. 72,p. 5759 - 5770.

41
[ 958879-25-9 ]
[ 7635-54-3 ]
(1S,2R,5S)-2-isopropyl-5-methylcyclohexyl 1,1-dimethyl-3,4-dihydrospiro[carbazole-2,2'-[1,3]dioxolane]-9(1H)-carboxylate [ No CAS ]

References: [1]Organic Letters,2007,vol. 9,p. 4623 - 4626.

42
[ 7635-54-3 ]
2,2'-dimethyl-8,8'-dihydroxy-1,1'-binaphthyl [ No CAS ]

References: [1]Journal of Organic Chemistry,1999,vol. 64,p. 7921 - 7928.

43
[ 7635-54-3 ]
2,2'-dimethyl-8,8'-dihydroxy-1,1'-binaphthyl [ No CAS ]

References: [1]Journal of Organic Chemistry,1999,vol. 64,p. 7921 - 7928.

44
[ 7635-54-3 ]
[ 104461-75-8 ]

References: [1]Tetrahedron Letters,1985,vol. 26,p. 5433 - 5436.

45
[ 7635-54-3 ]
[ 126378-46-9 ]

References: [1]Journal of Organic Chemistry,1990,vol. 55,p. 2574 - 2576.

46
[ 7635-54-3 ]
[ 126378-46-9 ]

References: [1]Journal of Organic Chemistry,1990,vol. 55,p. 2574 - 2576.

47
[ 7635-54-3 ]
[ 126378-48-1 ]

References: [1]Journal of Organic Chemistry,1990,vol. 55,p. 2574 - 2576.

48
[ 7635-54-3 ]
[ 126378-48-1 ]

References: [1]Journal of Organic Chemistry,1990,vol. 55,p. 2574 - 2576.

49
[ 7635-54-3 ]
1-(4-bromo-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline; hydrochloride [ No CAS ]
[ 1005456-39-2 ]

References: [1]Patent: US2004/19078,2004,A1 .Location in patent: Page/Page column 14.

50
[ 862573-15-7 ]
[ 7635-54-3 ]
[ 1151683-16-7 ]

Yield	Reaction Conditions	Operation in experiment
49.1%	With dmap; In dichloromethane; for 16h;Heating / reflux;	[00166] Example 2[00167] (i?)-l-((2-(l-(Benzo[^l[l,3]dioxol-6-yl)cyclopropanecarboxamido)thiazol- 5-yl)(2-chlorophenyl)methyl)pyrrolidin-3-yl (liS^i?^^-l-isopropyl-S-methylcyclohexyl carbonate[00168] l-(Benzo[rf][l,3]dioxol-5-yl)-N-(5-((2-chlorophenyl)((i?)-3- hydroxypyi?olidin-l-yl)methyl)thiazol-2-yl)cyclopropanecarboxamide (3.00 g, 6.02 mmol) was suspended in 200 mL of anhydrous dichloromethane containing ??iV-dimethylpyridin-4- amine (2.20 g, 18.0 mmol). (lL,2i?,55)-2-Isopropyl-5-metriylcyclohexyl chloroformate (1.91 mL, 9.00 mmol) was slowly added to the suspension and the resulting mixture was heated to reflux for 16 hours. The resulting pale yellow solution was allowed to cool to room temperature, diluted with 20 mL of methanol, and then evaporated to dryness. The crude reaction mixture was separated on 330 g of silica gel utilizing a gradient of 0-5% methanol in dicholoromethane to yield the pure product as a pale yellow solid (2.0087 g, 2.9529 mmol, 49.1%). ESI-MS m/z calc. 679.3, found; 680.5 (M+l)+; Retention time 3.88 minutes.

References: [1]Patent: WO2007/21982,2007,A2 .Location in patent: Page/Page column 50-51.

51
[ 3230-65-7 ]
[ 7635-54-3 ]
C₂₀H₂₈NO₂⁽¹⁺⁾*Cl^(1-) [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In toluene; at 20℃; for 24h;	General procedure for preparing diastereomeric products4 and 5: A Schlenk under a nitrogen atmosphere was charged with 3,4- dihydroisoquinoline (1.0 mmol). (-)-Menthyl chloroformate (1.0 mmol) and toluene (2 ml_) were subsequently added. The reaction mixture was stirred at room temperature over a period of 24 hours. Naphthol or a naphthol derivative <n="33"/>(1.0 mmol) was then added and the resulting mixture was stirred for another 24 hours. After being transferred to a round bottom flask comprising chloroform, the solvent was removed and the resulting diastereomers were separated by flash column chromatography on silica gel (hexane/dichloromethane = 2:1 , 1 :1 ).

References: [1]Patent: WO2007/98608,2007,A1 .Location in patent: Page/Page column 31-32.

52
[ 7635-54-3 ]
[ 99553-79-4 ]
[ 1017848-52-0 ]

References: [1]Journal of Organic Chemistry,2008,vol. 73,p. 2784 - 2791.

53
[ 7635-54-3 ]
[ 217446-35-0 ]
[ 1017848-54-2 ]

References: [1]Journal of Organic Chemistry,2008,vol. 73,p. 2784 - 2791.

54
[ 1046789-84-7 ]
[ 7635-54-3 ]
[ 1046789-85-8 ]

References: [1]Journal of Organometallic Chemistry,2008,vol. 693,p. 2431 - 2437.

Historical Records

Technical Information

• Acyl Group Substitution • Alkyl Halide Occurrence • Catalytic Hydrogenation • Complex Metal Hydride Reductions • General Reactivity • Grignard Reaction • Halogenation • Heat of Combustion • Hiyama Cross-Coupling Reaction • Hydride Reductions • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Preparation of Aldehydes and Ketones • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Rosenmund Reduction • Specialized Acylation Reagents-Ketenes • Stille Coupling • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling

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P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 7635-54-3

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CAS No.: 7635-54-3

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