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Chemical Structure| 22026-39-7 Chemical Structure| 22026-39-7

Structure of 22026-39-7

Chemical Structure| 22026-39-7

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Product Details of [ 22026-39-7 ]

CAS No. :22026-39-7
Formula : C8H8N2O3
M.W : 180.16
SMILES Code : O=C(C1=CC=C(OCO2)C2=C1)NN
MDL No. :MFCD00060505
InChI Key :RAXBGBHBUFGWPG-UHFFFAOYSA-N
Pubchem ID :89158

Safety of [ 22026-39-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P233-P260-P261-P264-P271-P280-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501

Application In Synthesis of [ 22026-39-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 22026-39-7 ]

[ 22026-39-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 103854-64-4 ]
  • [ 22026-39-7 ]
  • C19H15N3O4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
In ethanol; at 80℃; for 3h; General procedure: 8-Methoxyquinoline-2-carbaldehyde (25, 0.534 mmol) was refluxedwith various substituted acylhydrazines (0.587 mmol, 1.1 eq) in ethanol(5-10 mL) to get acyl hydrazides of 8-hydroxyquinoline. After completionof reaction, quinoline acyl hydrazides were found as precipitateson cooling to -15 C. Precipitates were washed with coldethanol and dried under vacuum. These acyl hydrazides were used directlyfor one pot synthesis of 2,5-disubstituted-1,3,4-oxadiazole usingiodine/K2CO3 catalysed oxidative cyclization. To the acyl hydrazides(1.0 eq) in DMSO (5-10 mL), K2CO3 (3.0 eq) and iodine (1.2 eq) wereadded in sequence and refluxed at 110 C. After the completion, thereaction mixture was cooled and saturated solution of sodium thiosulfatewas added. The precipitates were collected and dried under highvacuum to get the respective compounds (33-50).
 

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