[ CAS No. 2719-27-9 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]}

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

2D 3D

Structure of 2719-27-9 * Storage: {[proInfo.prStorage]}

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	Login	Inquiry	{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price) ]}	{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]}	Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price) ]}	{[ item.pr_usastock ]}		{[ item.pr_chinastock ]}	{[ item.pr_remark ]}	Login		Inquiry

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

For Research Only 120K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 2719-27-9 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 2719-27-9 ]

SDS Specification

Alternatived Products of [ 2719-27-9 ]

Product Citations Expand+

Synthesis and Characterization of 5-(2-Fluoro-4-[11C]methoxyphenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide as a PET Imaging Ligand for Metabotropic Glutamate Receptor 2

Yuan, Gengyang ; Dhaynaut, Maeva ; Lan, Yu , et al. J. Med. Chem.,2022,65(3):2593-2609. DOI: 10.1021/acs.jmedchem.1c02004 PubMed ID: 35089713

Abstract: Metabotropic glutamate receptor 2 (mGluR2) is a therapeutic target for several neuropsychiatric disorders. An mGluR2 function in etiology could be unveiled by positron emission tomography (PET). In this regard, 5-(2-fluoro-4-[11C]methoxyphenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide ([11C]13, [11C]mG2N001), a potent negative allosteric modulator (NAM), was developed to support this endeavor. [11C]13 was synthesized via the O-[11C]methylation of phenol 24 with a high molar activity of 212 ± 76 GBq/μmol (n = 5) and excellent radiochemical purity (>99%). PET imaging of [11C]13 in rats demonstrated its superior brain heterogeneity and reduced accumulation with pretreatment of mGluR2 NAMs, VU6001966 (9) and MNI-137 (26), the extent of which revealed a time-dependent drug effect of the blocking agents. In a nonhuman primate, [11C]13 selectively accumulated in mGluR2-rich regions and resulted in high-contrast brain images. Therefore, [11C]13 is a potential candidate for translational PET imaging of the mGluR2 function.

Purchased from AmBeed: 16289-54-6 ; 5521-55-1 ; 22047-25-2 ; 98-80-6 ; 40155-47-3 ; 5720-05-8 ; 879-65-2 ; 98-96-4 ; 31519-62-7 ; 23688-89-3 ; 23611-75-8 ; 33332-25-1 ; 20737-42-2 ; 61442-38-4 ; 17933-03-8 ; 50681-25-9 ; 13924-99-7 ; 40155-43-9 ; 166744-78-1 ; 36070-80-1 ; 4595-61-3 ; 118853-60-4 ; 41110-28-5 ; 40155-42-8 ; 937669-80-2 ; 31462-59-6 ; 16419-60-6 ; 5424-01-1 ; 59-67-6 ; 34604-60-9 ; 27398-39-6 ; 1196151-53-7 ; 19847-12-2 ; 13965-03-2 ; 876161-05-6 ; 27825-21-4 ; 2164-61-6 ; 4604-72-2 ; 98-97-5 ; 24005-61-6 ; 5521-61-9 ; 2516-34-9 ; 2719-27-9 ; 123-90-0 ; 6761-50-8 ; 625-43-4 ; 872-64-0 ; 1309866-36-1 ; 36932-49-7 ; 1528085-68-8 ; 1195533-51-7 ; 13534-79-7 ...More

Structure activity relationship of pyrazinoic acid analogs as potential antimycobacterial agents

Hegde, Pooja V. ; Aragaw, Wassihun W. ; Cole, Malcolm S. , et al. Bioorgan. Med. Chem.,2022,74,117046. DOI: 10.1016/j.bmc.2022.117046 PubMed ID: 36228522

Abstract: Tuberculosis (TB) remains a leading cause of infectious disease-related mortality and morbidity. Pyrazinamide (PZA) is a critical component of the first-line TB treatment regimen because of its sterilizing activity against non-replicating Mycobacterium tuberculosis (Mtb), but its mechanism of action has remained enigmatic. PZA is a prodrug converted by pyrazinamidase encoded by pncA within Mtb to the active moiety, pyrazinoic acid (POA) and PZA resistance is caused by loss-of-function mutations to pyrazinamidase. We have recently shown that POA induces targeted protein degradation of the enzyme PanD, a crucial component of the CoA biosynthetic pathway essential in Mtb. Based on the newly identified mechanism of action of POA, along with the crystal structure of PanD bound to POA, we designed several POA analogs using structure for interpretation to improve potency and overcome PZA resistance. We prepared and tested ring and carboxylic acid bioisosteres as well as 3, 5, 6 substitutions on the ring to study the structure activity relationships of the POA scaffold. All the analogs were evaluated for their whole cell antimycobacterial activity, and a few representative mols. were evaluated for their binding affinity, towards PanD, through isothermal titration calorimetry. We report that analogs with ring and carboxylic acid bioisosteres did not significantly enhance the antimicrobial activity, whereas the alkylamino-group substitutions at the 3 and 5 position of POA were found to be up to 5 to 10-fold more potent than POA. Further development and mechanistic anal. of these analogs may lead to a next generation POA analog for treating TB.

Keywords: Tuberculosis ; Pyrazinoic acid ; pyrazinamide

Purchased from AmBeed: 16289-54-6 ; 5521-55-1 ; 22047-25-2 ; 98-80-6 ; 40155-47-3 ; 5720-05-8 ; 879-65-2 ; 98-96-4 ; 31519-62-7 ; 23688-89-3 ; 23611-75-8 ; 33332-25-1 ; 20737-42-2 ; 61442-38-4 ; 17933-03-8 ; 50681-25-9 ; 13924-99-7 ; 40155-43-9 ; 36070-80-1 ; 4595-61-3 ; 118853-60-4 ; 41110-28-5 ; 40155-42-8 ; 937669-80-2 ; 98-98-6 ; 31462-59-6 ; 16419-60-6 ; 5424-01-1 ; 59-67-6 ; 34604-60-9 ; 27398-39-6 ; 1196151-53-7 ; 19847-12-2 ; 13965-03-2 ; 876161-05-6 ; 27825-21-4 ; 2164-61-6 ; 4604-72-2 ; 98-97-5 ; 24005-61-6 ; 103-67-3 ; 5521-61-9 ; 2516-34-9 ; 2719-27-9 ; 123-90-0 ; 6761-50-8 ; 625-43-4 ; 872-64-0 ; 36932-49-7 ; 1528085-68-8 ; 1195533-51-7 ; 13534-79-7 ...More

Product Details of [ 2719-27-9 ]

CAS No. :	2719-27-9	MDL No. :	MFCD00001456
Formula :	C₇H₁₁ClO	Boiling Point :	-
Linear Structure Formula :	ClC(O)C₆H₁₁	InChI Key :	RVOJTCZRIKWHDX-UHFFFAOYSA-N
M.W :	146.61	Pubchem ID :	75938
Synonyms :

Safety of [ 2719-27-9 ]

Signal Word:	Danger	Class:	8
Precautionary Statements:	P261-P280-P305+P351+P338-P310	UN#:	3265
Hazard Statements:	H227-H314-H335	Packing Group:	Ⅱ
GHS Pictogram:

Application In Synthesis of [ 2719-27-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 2719-27-9 ]

[ 2719-27-9 ] Synthesis Path-Downstream 1~17

1
[ 2719-27-9 ]
[ 98-89-5 ]
[ 22651-87-2 ]

Yield	Reaction Conditions	Operation in experiment
	With pyridine; In diethyl ether; for 10h;	To an ether solution (5 mL) of cyclohexanecarboxylic acid (250 mg, 1.95 mmol) was added pyridine (0.5 mL) and cyclohexanecarbonyl chloride (286 mg, 0.261 mL, 1.95 MMOL). After 10 h, the suspension was diluted with ether (20 mL), washed with ice-cold 5% HCl solution (1x50 mL) and concentrated NaHCO3 solution (1x50 mL) and dried over Na2S04. All solvent was removed in vacua to give 350 mg of cyclohexanecarboxylic anhydride as A colorless oil. A portion of the cyclohexanecarboxylic anhydride. (226 mg, 0. 948 mmol) was added to a sodium carbonate solution (1 M, 2 mL) of the aminophosphate 21a (110 mg, 0.412 mmol). After 15 h, it was acidified to PH#1 by addition of concentrated HCI solution at 0 C. Preparative HPLC purification afforded 50 mg (36% yield) of the title compound 25-17. 1H NMR (CD3OD) : δ 7. 27-7. 1 (5H, m), 6.67 (1H, br d), 4.34 (1H, br s), 4.08 (1H, m), 3.96 (1H, m), 2.90 (1H, dd, J=14.4, 6.6 Hz), 2. 78 (1H, dd, J=14.9, 9 Hz), 2.10 (1H, br t), 1.79-1. 51 (5H, m), 1. 33-1. 02 (5H, m); LCMS (ESP): 342 (M+H+) ; 340 (M-H)-.
	With pyridine; In diethyl ether; for 10h;	Example 25-17 Phosphoric acid mono-{2-[(1-cyclohexyl-methanoyl)-amino]-3-phenyl-propyl}ester To an ether solution (5 mL) of cyclohexanecarboxylic acid (250 mg, 1.95 mmol) was added pyridine (0.5 mL) and cyclohexanecarbonyl chloride (286 mg, 0.261 mL, 1.95 mmol). After 10 h, the suspension was diluted with ether (20 mL), washed with ice-cold 5% HCl solution (150 mL) and concentrated NaHCO3 solution (150 mL) and dried over Na2SO4. All solvent was removed in vacuo to give 350 mg of cyclohexanecarboxylic anhydride as a colorless oil.
		General procedure: To a flamed-dried flask with magnetic stir bar, was added aliphatic acid (1.0 equiv), dried DCM (1.0 M) and triethylamine (1.05 equiv) successively. The solution was stirred for 30 minutes at 0 0C. Then acyl chloride (1.05 equiv) was added dropwise to the mixture and stirred overnight at rt. The solvent was evaporated by vacuum to afford the crude mixture. And the mixture was dissolved in n-hexane. Then the residue was filtered through a small plug of celite and concentrated to afford the anhydrides. This product was used to next catalytic reaction without any further purification.

Reference： [1]New Journal of Chemistry,2019,vol. 43,p. 10711 - 10715
[2]Organic Letters,2019,vol. 21,p. 7154 - 7157
[3]Doklady Akademii Nauk SSSR,1936,vol. 13,p. 417
[4]Patent: WO2004/87720,2004,A1 .Location in patent: Page 57
[5]Patent: US2005/250742,2005,A1 .Location in patent: Page/Page column 37
[6]New Journal of Chemistry,2017,vol. 41,p. 931 - 939
[7]Organic Letters,2019,vol. 21,p. 3625 - 3630
[8]Tetrahedron,2019,vol. 75,p. 4186 - 4191

2
[ 20075-26-7 ]
[ 2719-27-9 ]
Cyclohexyl-(4,5-dibromo-1H-imidazol-2-yl)-methanone [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,1997,vol. 7,p. 89 - 94

3
[ 21617-20-9 ]
[ 2719-27-9 ]
6-Chloro-1-cyclohexanecarbonyl-2,3-dihydro-1H-quinolin-4-one [ No CAS ]

Reference： [1]European Journal of Medicinal Chemistry,1998,vol. 33,p. 267 - 277

4
[ 4877-80-9 ]
[ 2719-27-9 ]
C₆₀H₇₂O₁₂ [ No CAS ]

Reference： [1]Physical Chemistry Chemical Physics,1999,vol. 1,p. 1757 - 1760

5
[ 932-32-1 ]
[ 2719-27-9 ]
N-(2-chlorophenyl)-N-methylcyclohexanecarbamide [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2001,vol. 66,p. 3402 - 3415

6
[ 28992-50-9 ]
[ 2719-27-9 ]
resin-bound isobutylamine [ No CAS ]
(5-cyclohexyl-[1,2,4]oxadiazol-3-yl)-isobutyl-amine [ No CAS ]

Reference： [1]Tetrahedron Letters,2002,vol. 43,p. 5043 - 5045

7
[ 40230-24-8 ]
[ 2719-27-9 ]
cyclohexanecarboxylic acid-(4,6-diphenyl-pyrimidin-2-yl)-amide [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2004,vol. 47,p. 6529 - 6540

8
[ 16687-60-8 ]
[ 2719-27-9 ]
[ 866358-13-6 ]

Yield	Reaction Conditions	Operation in experiment
100%	With pyridine; at 20 - 100℃; for 3h;	A mixture of <strong>[16687-60-8]5-(4-nitro-phenyl)-1H-tetrazol</strong>e (0. 5 g, 2. 62 mmol) and cyclohexane carbonyl chloride (0. 35 mi, 2. 62 mmol) in 3 mi anhydrous pyridine was stirred at room temperature under nitrogen for 20 min, then heated to 60 C for 1 hr and finally heated to 100 C for 2 h. The reaction mixture was cooled to room temperature then poured onto ice (30 g) and the aqueous mixture was extracted with 30 ml ethyl acetate. The ethyl acetate solution was washed sequentially with 30 mi water, 30 mi 1 N aqueous hydrochloric acid solution and 30 mi brine, dried (anhydrous sodium sulfate) and concentrated under reduced pressure. The crude produce was purified by flash column chromatography (silica gel, 40 g), eluting with 4 : 1 hexane/ethyl acetate to yield the title compound as a yellowish solid (0. 5 g, 100% yield). MS : 274. 2 (M+1)

Reference： [1]Patent: WO2005/92845,2005,A1 .Location in patent: Page/Page column 134

9
[ 51175-79-2 ]
[ 2719-27-9 ]
[ 1057478-76-8 ]

Reference： [1]Russian Journal of Organic Chemistry,2007,vol. 43,p. 1628 - 1631

10
[ 136-01-6 ]
[ 2719-27-9 ]
[ 22651-87-2 ]

Reference： [1]Organic and Biomolecular Chemistry,2007,vol. 5,p. 3993 - 4000

11
[ 2719-27-9 ]
[ 22651-87-2 ]

Yield	Reaction Conditions	Operation in experiment
	With water; triethylamine; In dichloromethane; at 0 - 20℃;Inert atmosphere;	General procedure: TCCA (0.256 g, 1.1 mmol) was portionwise added over a period of 1-2 min to a solution of an aldehyde (1.1 mmol) in 3.25 mL dichloromethane, under dry argon atmosphere and at room temperature. The resulting suspension was stirred at room temperature and under dry argon. The reaction was monitored by TLC until disappearance of the aldehyde. Then the reaction mixture was cooled to 0 C and were added water (1.0 mmol) and NEt3 (0.202 g, 2.0 mmol). After completion of the additions, the reaction mixture left to stir at room temperature until disappearance of the acyl chloride, monitored by TLC. For the products 4a-4g, the solvent was evaporated under reduced pressure and the residue purified by flash chromatography. For the products 4h-4l the reaction mixture was washed three times with a solution of 5 % HCl and then three times with a solution of 5 % NaHCO3; the organic phase was dried over anhydrous Na2SO4 and the solvent was evaporated under reduced pressure providing the desired anhydride.

Reference： [1]Tetrahedron Letters,2008,vol. 49,p. 5322 - 5323
[2]Advanced Synthesis and Catalysis,2013,vol. 355,p. 3137 - 3140
[3]Tetrahedron Letters,2017,vol. 58,p. 2533 - 2536

12
[ 2719-27-9 ]
[ 5234-86-6 ]
praziquantel [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
43%	In dichloromethane; at 0 - 20℃;Inert atmosphere;	General procedure: To a stirred solution of compound 16 (500 mg, 2.7 mmol) in DCM (50 mL), cyclohexanecarbonyl chloride (532 L, 4.0 mmol) was added at 0 C. The mixture was stirred at room temperature overnight. The reaction was quenched with NaHCO3 (aq.), extracted with DCM (50 mL × 3). The organic phases were then processed in the usual way and chromatographed (1:1 petroleum ether/ EtOAc) to afforded compound 19 (350 mg, 43%) as white solid.

Reference： [1]Molecules,2013,vol. 18,p. 9163 - 9178

13
[ 161420-87-7 ]
[ 2719-27-9 ]
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(cyclohexanecarboxamido)butanoic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
70%	With sodium hydroxide; In tetrahydrofuran; at 0 - 20℃; for 1h;	(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(cyclohexanecarboxamido)butanoic acid Cyclohexanecarbonyl chloride (86 mg, 0.588 mmol) and NaOH (0.705 mL, 0.705 mmol) were dropped at the same time to a stirred solution of <strong>[161420-87-7](S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-aminobutanoic acid</strong> (200 mg, 0.588 mmol) in THF (1.5 mL) and of NaOH (1N, 0.7 mL) at 0 C. The reaction mixture was allowed to stir at rt for 1 h at which time LC-MS showed desired product peak. The reaction solution was acidified with 1N HCl and extracted with EtOAc (60 mL*1). The crude materials were purified via flash chromatography (ISCO, silica gel, 12 g column; flow rate 30 mL/min, 100% DCM to 20% MeOH/DCM). Fractions containing the desired product were combined and dried via centrifugal evaporation to provide the title compound (201 mg, 70%). Analysis LCMS Condition A: Retention time=1.01 min; ESI-MS(+) m/z 451.2 (M+H) 1H NMR (400 MHz, methanol-d4): delta 7.79 (d, J=7.5 Hz, 2H), 7.73-7.65 (m, 2H), 7.43-7.35 (m, 2H), 7.34-7.26 (m, 2H), 4.42-4.30 (m, 2H), 4.27-4.15 (m, 2H), 3.18 (d, J=7.3 Hz, 1H), 2.15 (s, 1H), 2.10-2.01 (m, 1H), 1.89-1.72 (m, 5H), 1.68 (d, J=10.3 Hz, 1H), 1.49-1.17 (m, 6H)

Reference： [1]Patent: US9308236,2016,B2 .Location in patent: Page/Page column 297

14
[ 2719-27-9 ]
[ 446065-11-8 ]
[ 119-60-8 ]

Reference： [1]Journal of Organic Chemistry,2017,vol. 82,p. 1856 - 1863

15
[ 128742-76-7 ]
[ 2719-27-9 ]
C₁₈H₂₁NO₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With aluminum (III) chloride; In dichloromethane; at 0 - 20℃; for 18h;	At a temperature of 0C, a round bottom flask was charged with cyclohexanecarbonyl chloride (465 mg, 3.17 mmol), DCM (15 mL), A1C13 (423 mg, 3.17mmol) and magnetic stir bar. The reaction mixture was allowed to stir and come to rt. Indole 9 (200 mg, 1.06 mmol) was added as a DCM (6 mL) solution over the course of 25 mm. The reaction mixture was then stirred for 18 h. The reaction was quenched with saturated NH4C1, extracted with DCM, dried with Na2SO4, solvent removed under reduced pressure and purified using flash column chromatography. The ester intermediate was hydrolyzed in 2 M NaOH in refluxing MeOH for 4 h. The reaction mixture was cooled, acidified with 1 M HC1 and allowed to solidify upon standing. The carboxylic acid product was collected by vacuum filtration and used without further purification. ?H NIVIR (400 IVIHz, DMSO-d6) 12.60 (br. s., 1H), 8.90 (s, 1H), 8.48 (s, 1H), 7.87 (dd, J= 1.4, 8.8 Hz, 1H), 7.58 (d, J= 9.0 Hz, 1H), 3.88 (s, 3H), 3.11 (t, J 10.3 Hz, 1H), 1.78 (t, J= 11.5 Hz, 4H), 1.68 (d, J= 12.1 Hz, 1H),1.52- 1.30 (m, 4H), 1.26 - 1.14 (m, 1H). ?3C NIVIR (101 IVIHz, DMSO-d6) 198.4, 168.1,139.7, 138.7, 125.7, 124.4, 124.1, 123.9, 114.7, 110.4, 46.4, 33.3, 29.6, 25.6, 25.4.

Reference： [1]Patent: WO2018/237163,2018,A1 .Location in patent: Paragraph 0059; 0061

16
[ 2719-27-9 ]
[ 6294-52-6 ]
N-(5,6-dihydroxybenzo[d]thiazol-2-yl)cyclohexanecarboxamide [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2019

17
[ 2719-27-9 ]
[ 6294-52-6 ]
N-(5,6-dimethoxybenzo[d]thiazol-2-yl)cyclohexanecarboxamide [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2019

Recommend Products

Same Skeleton Products

Related Products

Isomers

Technical Information

• Acyl Group Substitution • Alkyl Halide Occurrence • Catalytic Hydrogenation • Complex Metal Hydride Reductions • General Reactivity • Grignard Reaction • Halogenation • Heat of Combustion • Hiyama Cross-Coupling Reaction • Hydride Reductions • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Preparation of Aldehydes and Ketones • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Rosenmund Reduction • Specialized Acylation Reagents-Ketenes • Stille Coupling • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling

Historical Records

Related Functional Groups of
[ 2719-27-9 ]

Aliphatic Cyclic Hydrocarbons

[ 67589-87-1 ]

Trans-4-ethylcyclohexanecarbonyl chloride

Similarity: 1.00

[ 84855-54-9 ]

Trans-4-isopropylcyclohexanecarbonyl chloride

Similarity: 1.00

[ 67589-91-7 ]

Trans-4-hexylcyclohexanecarbonyl chloride

Similarity: 1.00

[ 146606-05-5 ]

Cis-4-butylcyclohexanecarbonyl chloride

Similarity: 1.00

[ 80022-86-2 ]

Trans-4-octylcyclohexanecarbonyl chloride

Similarity: 1.00

Chlorides

[ 13170-66-6 ]

Cyclohexane-1,4-dicarbonyl dichloride

Similarity: 1.00

[ 84855-54-9 ]

Trans-4-isopropylcyclohexanecarbonyl chloride

Similarity: 1.00

[ 67589-91-7 ]

Trans-4-hexylcyclohexanecarbonyl chloride

Similarity: 1.00

[ 146606-05-5 ]

Cis-4-butylcyclohexanecarbonyl chloride

Similarity: 1.00

[ 80022-86-2 ]

Trans-4-octylcyclohexanecarbonyl chloride

Similarity: 1.00

Acyl Chlorides

[ 13170-66-6 ]

Cyclohexane-1,4-dicarbonyl dichloride

Similarity: 1.00

[ 84855-54-9 ]

Trans-4-isopropylcyclohexanecarbonyl chloride

Similarity: 1.00

[ 67589-91-7 ]

Trans-4-hexylcyclohexanecarbonyl chloride

Similarity: 1.00

[ 146606-05-5 ]

Cis-4-butylcyclohexanecarbonyl chloride

Similarity: 1.00

[ 80022-86-2 ]

Trans-4-octylcyclohexanecarbonyl chloride

Similarity: 1.00

Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 2719-27-9 ] {[proInfo.proName]}

Quality Control of [ 2719-27-9 ]

Related Doc. of [ 2719-27-9 ]

Product Citations Expand+

Product Details of [ 2719-27-9 ]

Safety of [ 2719-27-9 ]

Application In Synthesis of [ 2719-27-9 ]

[ 2719-27-9 ] Synthesis Path-Downstream 1~17

Technical Information

Related Functional Groups of [ 2719-27-9 ]

Aliphatic Cyclic Hydrocarbons

Chlorides

Acyl Chlorides

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 2719-27-9 ]