6214-35-3|(Z)-(3)-Iodoacrylic acid| Ambeed

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Structure of 6214-35-3

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Quality Control of [ 6214-35-3 ] Purity: 95% SDS Specification

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Product Details of [ 6214-35-3 ]

CAS No. :	6214-35-3
Formula :	C₃H₃IO₂
M.W :	197.96
SMILES Code :	O=C(O)/C=C\I
MDL No. :	MFCD00274189
InChI Key :	IBFDLVHJHUMSAC-UPHRSURJSA-N
Pubchem ID :	643796

Safety of [ 6214-35-3 ]

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H314
Precautionary Statements:	P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P405-P501
Class:	8
UN#:	3261
Packing Group:	Ⅲ

Application In Synthesis of [ 6214-35-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 6214-35-3 ]

[ 6214-35-3 ] Synthesis Path-Downstream 1~35

1
[ 79-21-0 ]
[ 6214-35-3 ]
cis-3-iodosyl-acrylic acid [ No CAS ]

References: [1]Proceedings of the Koninklijke Nederlandse Akademie van Wetenschappen, Series B: Physical Sciences,1932,vol. 35,p. 1142.
Chemisches Zentralblatt,1933,vol. 104,p. 1938.

2
cis-3-iodosyl-acrylic acid [ No CAS ]
[ 6214-35-3 ]

References: [1]Proceedings of the Koninklijke Nederlandse Akademie van Wetenschappen, Series B: Physical Sciences,1932,vol. 35,p. 1142.
Chemisches Zentralblatt,1933,vol. 104,p. 1938.

3
[ 6214-35-3 ]
cis-3-iodosyl-acrylic acid [ No CAS ]

References: [1]Proceedings of the Koninklijke Nederlandse Akademie van Wetenschappen, Series B: Physical Sciences,1932,vol. 35,p. 1142.
Chemisches Zentralblatt,1933,vol. 104,p. 1938.

4
[ 6214-35-3 ]
[ 542-92-7 ]
[ 71702-11-9 ]
[ 71702-11-9 ]

References: [1]Justus Liebigs Annalen der Chemie,1958,vol. 613,p. 6,26.

5
[ 2956-91-4 ]
[ 6214-35-3 ]

References: [1]Acta Chemica Scandinavica (1947),1969,vol. 23,p. 2839 - 2847.

6
[ 6214-35-3 ]
[ 55711-93-8 ]

References: [1]Journal of Organic Chemistry,1975,vol. 40,p. 2891 - 2897.
[2]European Journal of Organic Chemistry,2008,p. 5215 - 5220.

7
[ 67-56-1 ]
[ 6214-35-3 ]
[ 6214-23-9 ]
[ 6213-88-3 ]

References: [1]Journal of the American Chemical Society,1989,vol. 111,p. 6729 - 6734.

8
[ 6214-35-3 ]
[ 623-43-8 ]
(E)-5-methoxycarbonyl-4-methyl-2-pentenoic acid [ No CAS ]

References: [1]Tetrahedron,1994,vol. 50,p. 6715 - 6720.

9
[ 6214-35-3 ]
[ 75-35-4 ]
(E)-5,5-dichloro-2-pentenoic acid [ No CAS ]

References: [1]Tetrahedron,1994,vol. 50,p. 6715 - 6720.

10
[ 6214-35-3 ]
[ 2680-03-7 ]
(E)-6-dimethylamino-6-oxo-2-hexenoic acid [ No CAS ]

References: [1]Tetrahedron,1994,vol. 50,p. 6715 - 6720.

11
[ 6214-35-3 ]
[ 96-05-9 ]
(E)-5-allyloxycarbonyl-2-hexenoic acid [ No CAS ]

References: [1]Tetrahedron,1994,vol. 50,p. 6715 - 6720.

12
[ 6214-35-3 ]
[ 109669-45-6 ]
[ 71443-20-4 ]

References: [1]Tetrahedron Letters,1992,vol. 33,p. 409 - 412.

13
[ 6214-35-3 ]
[ 6372-02-7 ]

Yield	Reaction Conditions	Operation in experiment
95%	With hydrogen iodide; In water; benzene; at 80℃; for 5h;	To a solution of 55% aqueous HI (0.3 mL) and benzene(4.3 mL) was added (Z)- propenoic acid (3.6 g, 18 mmol). The mixture was heated at80 C for 5 h. After the mixture cooled to room temperature, ether was added, and thelayers were separated. The aqueous layer was extracted with ether, and the combinedorganic layers were washed with aqueous Na2S2O3 and dried (MgSO4). The solventwas evaporated in vacuo. The residue was washed with n-hexane, giving 3.4 g of(E)-propenoic acid in 95% yield as a white crystal. The spectral data was inaccordance with the literature [1].
89%	With hydrogen iodide; In water; benzene; at 80℃; for 5h;	The procedure of Step 2 was carried out according to the protocol put forth by Takeuchi et al, Journal of Organic Chemistry, 2000 (65), 1558-61. (Z)-3- Iodo-acrylic acid (5.94 g, 30 mmol)was added to a solution of 55% aqueous hydroiodic acid (0.6 mL) and benzene (8 mL). The mixture was heated at 800C for 5 hours, cooled to ambient temperature, diluted with ether and extracted. The aqueous layer was extracted with ether, and the combined organic layers were washed with aqueous sodium thiosulphate and dried magnesium sulfate. The solvent was evaporated in vacuo. The solvent was evaporated in vacuo, <n="63"/>and the residue was washed with n-hexane to give the title compound as a pale yellow solid, yield 5.29 g (89%); mp 144-147 0C. 1H NMR (270 MHz, CDCl3) δ 6.90 (d, J = 14.8 Hz, IH), 8.09 (d, J = 14.8 Hz, IH), 10.0 (br, IH). 13C NMR (67.8 MHz, CDCl3) δ 103.2, 135.7, 169.4.

References: [1]Chinese Chemical Letters,2022.
[2]Journal of Organic Chemistry,2000,vol. 65,p. 1558 - 1561.
[3]Journal of Organic Chemistry,2007,vol. 72,p. 2525 - 2532.
[4]Patent: WO2008/73863,2008,A2 .Location in patent: Page/Page column 61-62.
[5]Tetrahedron Letters,1998,vol. 39,p. 6719 - 6720.
[6]Bulletin of the Polish Academy of Sciences: Chemistry,1984,vol. 32,p. 85 - 95.
[7]Journal of Organic Chemistry,1998,vol. 63,p. 2968 - 2974.

14
[ 6214-35-3 ]
[ 93620-26-9 ]

References: [1]Bulletin of the Polish Academy of Sciences: Chemistry,1984,vol. 32,p. 85 - 95.

15
[ 6214-35-3 ]
[ 107-13-1 ]
(E)-5-cyano-2-pentenoic acid [ No CAS ]

References: [1]Tetrahedron,1994,vol. 50,p. 6715 - 6720.

16
[ 6214-35-3 ]
[ 292638-85-8 ]
[ 89898-52-2 ]

References: [1]Tetrahedron,1994,vol. 50,p. 6715 - 6720.

17
[ 6214-35-3 ]
[ 80-62-6 ]
(E)-5-methoxycarbonyl-2-hexenoic acid [ No CAS ]

References: [1]Tetrahedron,1994,vol. 50,p. 6715 - 6720.

18
[ 6214-35-3 ]
[ 126-98-7 ]
(E)-5-cyano-2-hexenoic acid [ No CAS ]

References: [1]Tetrahedron,1994,vol. 50,p. 6715 - 6720.

19
[ 471-25-0 ]
[ 74-88-4 ]
[ 6214-35-3 ]

References: [1]Tetrahedron Letters,1983,vol. 24,p. 3973 - 3974.

20
[ 471-25-0 ]
[ 6214-35-3 ]

Yield	Reaction Conditions	Operation in experiment
96%	With hydrogen iodide; In water; at 50℃; for 17h;	To a solution of 55% aqueous HI (5.0 mL) and H2O (5.0mL) was added propynoic acid (1.2 mL, 20 mmol). The mixture was heated at 50 Cfor 17 h. After the mixture cooled to room temperature, ether was added, and thelayers were separated. The aqueous layer was extracted with ether, and the combinedorganic layers were washed with aqueous Na2S2O3 and dried (MgSO4). The solventwas evaporated in vacuo. The residue was washed with n-hexane, giving 3.8 g of(Z)-propenoic acid in 96% yield as a white soild. The spectral data was in accordancewith the literature [1].
90%	With hydrogen iodide; In water; at 50℃; for 17h;	The procedure of Step 1 was carried out according to the protocol put forth by Takeuchi et al, Journal of Organic Chemistry, 2000 (65), 1558-61. To a solution of 55% aqueous hydroiodic acid (20 mL) and water (30 mL) was added propynoic acid (7.0 g, 100 mmol). The mixture was heated at 500C for 17 hours. After the mixture cooled to ambient temperature, ether was added, and the layers were separated. The aqueous layer was extracted with ether, and the combined organic layers were washed with aqueous sodium thiosulphate and dried magnesium sulfate. The solvent was evaporated in vacuo, and the residue was washed with n-hexane to give the title compound as a pale yellow solid which is used directly in the next step; yield 17.8 g (90%). mp 68-70 0C (lit.10b mp 63-64 0C). 1H NMR (270 MHz, CDCl3) δ 6.99 (d, J = 9.2 Hz, IH), 7.69 (d, J = 9.2 Hz, IH), 9.94 (br, IH). 13C NMR (67.8 MHz, CDCl3) δ 98.2, 129.4, 169.7.
87%	With hydrogen iodide; In water; at 50℃; for 24h;	To a solution of 57 % hydrogen iodide (60 mL) in water (90 mL) was added propynoic acid (propiolic acid) 20 (20 g). The resulting mixture was heated at 50 C for 24 h. The mixture was cooled to room temperature and MTBE (100 mL) was added. The two layers were separated. The aqueous layer was extracted with MTBE (100 mL). The combined organic phase was washed with 2 M NaS203 (2 x 50 mL), 5 % NaCl and dried over MgS04. The solution was filtered and concentrated to dryness to afford a beige solid product 21 (49 g, 87%). To a solution of (Z)-3-iodo- acrylic acid 21 (48 g) and t-BuOAc (140 g) in CH2CI2 (144 mL, 3 vol.) was added TfOH (1.8 g). The solution was stirred at room temperature for 1 h. The reaction was deemed complete (acid: HPLC area% 20.27%). The solution was neutralized with 2 M K2CO3 (242 mL). Heptane (144 mL) was added. The two layers were separated. The aqueous layer was extracted with heptane (144 mL). The combined organic phase was washed with water (144 mL) and dried over MgS04. The solution was filtered and concentrated to dryness to afford an oil product 5 (49 g, 80%, HPLC area%: 98.22%).

87%	With hydrogen iodide; In tert-butyl methyl ether; water; at 50℃; for 24h;	To a solution of 57 % HI (60 mL) in water (90 mL) was added propynoic acid 20 (20 g). The resulting mixture was heated at 50 c for 24 h. The mixture was cooledto room temperature and MTBE (100 mL) was added. The two layers were separated. The aqueous layer was extracted with MTBE (100 mL). The combined organic phase was washed with 2 M Na5203 (2 x 50 mL), 5 % Nacl and dried over Mg504. The solution was filtered and concentrated to dryness to afford a beige solids product 21 (49 g, 87%). To a solution of (Z)-3-iodo-acrylic acid 21 (48 g) and t-BuOAc (140 g) inCH2C12 (144 mL, 3 vol.) was added TfOH (1.8 g). The solution was stirred at room temperature for 1 h. The reaction was deemed complete (acid: HPLC area% 20.27%). The solution was neutralized with 2 M K2c03 (242 mL). Heptane (144 mL) was added. The two layers were separated. The aqueous layer was extracted with heptane (144 mL). The combined organic phase was washed with water (144 mL) and dried overMg504. The solution was filtered and concentrated to dryness to afford an oil product5 (49 g, 80%, HPLC area%: 98.22%).
87%	With hydrogen iodide; In water; at 50℃; for 24h;	To a solution of 57 % HI (60 mL) in water (90 mL) is added propionic acid 20 (20 g). The resulting mixture is heated at 50C for 24 h. The mixture is cooled to room temperature and MTBE (100 mL) was added. The two layers were separated. The aqueous layer was extracted with MTBE (100 mL). The combined organic phase is washed with 2 M NaS203(2 x 50 mL), 5 % NaCl and dried over MgS04. The solution was filtered and concentrated to dryness to afford a beige solids product 21 (49 g, 87%). To a solution of (Z)-3-iodo-acrylic acid 21 (48 g) and t-BuOAc (140 g) in CH2CI2(144 mL, 3 vol.) was added TfOH (1.8 g). The solution is stirred at room temperature for 1 h. The reaction is deemed complete (acid: HPLC area% 20.27%). The solution is neutralized with 2 M K2CO3(242 mL). Heptane (144 mL) was added. The two layers are separated. The aqueous layer is extracted with heptane (144 mL). The combined organic phase is washed with water (144 mL) and dried over MgS04. The solution is filtered and concentrated to dryness to afford an oil product 5 (49 g, 80%, HPLC area%: 98.22%).
87%	With hydrogen iodide; In water; at 50℃; for 24h;	To a solution of 57 % HI (60 mL) in water (90 mL) was added propynoic acid 20’ (20 g). The resulting mixture was heated at 50 C for 24 h. The mixture was cooled to room temperature and MTBE (100 mL) was added. The two layers were separated. The aqueous layer was extracted with MTBE (100 mL). The combined organic phase was washed with 2 M NaS CT, (2 x 50 mL), 5 % NaCl and dried over MgSCL. The solution was filtered and concentrated to dryness to afford a beige solids product 21’ (49 g, 87%). To a solution of (Z)-3-iodo-acrylic acid 21’ (48 g) and t-BuOAc (140 g) in CH2CI2 (144 mL, 3 vol.) was added TfOH (1.8 g). The solution was stirred at room temperature for 1 h. The reaction was deemed complete (acid: HPLC area% 20.27%). The solution was neutralized with 2 M K2CO3 (242 mL). Heptane (144 mL) was added. The two layers were separated. The aqueous layer was extracted with heptane (144 mL). The combined organic phase was washed with water (144 mL) and dried over MgSCL. The solution was filtered and concentrated to dryness to afford an oil product 5’ (49 g, 80%, HPLC area%: 98.22%).
79%	With hydrogen iodide; In water; at 55℃; for 18h;Inert atmosphere; Large scale;	A 5-L three-neck round-bottom flask was equipped with overhead stirrer, temperature probe, argon inlet and outlet, and water-cooling condenser. The flask was charged with propiolic acid 25 (500 g, 7.14 mol), DI-water (2 L, 4 vol) and hydriodic acid (1.3 kg, 10.3 mol, 1.6 equiv.). The reaction mixture was heated to 55 C under argon for 18 h. HPLC analysis of the sample showed the presence of (Z)-3-iodo-acrylic acid 26 (>99% AUC). After cooling to ambient temperature, the solution was transferred to a 6-L separatory funnel. The product was extracted with MTBE (2 x 1 L) and the combined organic phase was washed with saturated sodium sulfite (200 mL) and brine (200 mL); dried over sodium sulfate for 3 h. Ethyl acetate (1 L) was added to dissolve the solid product (some crystallized during dryness). After filtration, the filtrates were concentrated on a rotary evaporator to remove most solvents. MTBE (500 mL) and heptane (500 mL) were added and the product was crystallized at ambient temperature for 18 h. The white solid was collected by filtration and dried in a vacuum oven at 45 C overnight to obtain 1.1 kg, of 26 (yield, 79%, purity 99% (AUC)).
40.44%	With acetic acid; sodium iodide; at 1000℃;	Synthesis of (Z)-3-iodoacrylic acid:0Nal ^ ^OHOH " γ YI oA 250-mL, three-necked, roubd-bottomed flask equipped with nitrogen inlet was added propiolic acid (7.0 g,1.0 eq) dissolved in acetic acid (70 mL,10V) and sodium iodide (29.96 g, 2.0eq). The reaction mixture was refluxed at 1000 C for 2-3 h. The progress of the reaction was followed by TLC analysis on silica gel with 10% MeOH:DCM as mobile phase. SM Rf =0.3 and Product Rf = 0.5. Reaction mixture was poured into ice water (700 mL) and neutralized with saturated solidum bicarbonate solution. The reaction mixture was extracted with EtOAc (3 x 100 mL). The combined organic layers were washed with brine solution (3 x 100 mL), dried over MgS04, filtered, and concentrated by rotary evaporation (25 C, 20 mmHg) to afford 12.0 g of crude compound which was purified by column chromatography using silica 60/120 using MeOH:DCM as mobile phase. The column (5 x 10 cm) was packed in DCM and started eluting in MeOH in gradient manner starting with fraction collection (50- mL fractions) from 2% to 5% MeOH in DCM. Compound started eluting with 2% MeOH in DCM. Fractions containing such TLC profile were combined to obtain 8.0 gm of desired compound (yield 40.44%).

References: [1]Chinese Chemical Letters,2022.
[2]Synthesis,1996,p. 82 - 86.
[3]Journal of Organic Chemistry,2002,vol. 67,p. 4127 - 4137.
[4]Tetrahedron Letters,2001,vol. 42,p. 1691 - 1694.
[5]Journal of Organic Chemistry,2000,vol. 65,p. 1558 - 1561.
[6]Patent: WO2008/73863,2008,A2 .Location in patent: Page/Page column 60-61.
[7]Journal of the Chemical Society. Chemical communications,1990,p. 1643 - 1644.
[8]Journal of Organic Chemistry,1992,vol. 57,p. 709 - 713.
[9]Organic letters,2000,vol. 2,p. 65 - 67.
[10]Patent: WO2017/193016,2017,A1 .Location in patent: Page/Page column 202.
[11]Patent: WO2017/193017,2017,A1 .Location in patent: Page/Page column 108.
[12]Patent: WO2019/234509,2019,A2 .Location in patent: Page/Page column 173.
[13]Patent: WO2020/115547,2020,A2 .Location in patent: Page/Page column 79.
[14]Journal of Organic Chemistry,2007,vol. 72,p. 2525 - 2532.
[15]Organic Letters,2018,vol. 20,p. 7679 - 7683.
[16]Tetrahedron Letters,2019,vol. 60,p. 371 - 374.
[17]Canadian Journal of Chemistry,1994,vol. 72,p. 1816 - 1819.
[18]Journal of the American Chemical Society,1989,vol. 111,p. 6729 - 6734.
[19]Tetrahedron Letters,2013,vol. 54,p. 2151 - 2155.
[20]Synthesis,1997,p. 121 - 128.
[21]Patent: WO2013/19548,2013,A1 .Location in patent: Page/Page column 88.
[22]Bulletin of the Polish Academy of Sciences: Chemistry,1984,vol. 32,p. 85 - 95.
[23]Synthetic Communications,1998,vol. 28,p. 239 - 249.
[24]Journal of Organic Chemistry,1998,vol. 63,p. 2968 - 2974.
[25]Synthetic Communications,2006,vol. 36,p. 3461 - 3471.
[26]Organic Letters,2000,vol. 2,p. 2479 - 2481.
[27]Synthesis,2006,p. 2951 - 2970.
[28]Synthesis,2008,p. 3465 - 3472.

21
[ 6214-35-3 ]
[ 498-66-8 ]
bicyclo<2.2.1>heptane-exo,exo-2,3-diylbis<(E/Z)-acrylic acid> [ No CAS ]

References: [1]Chemische Berichte,1994,vol. 127,p. 2539 - 2541.

22
[ 6214-35-3 ]
[ 7486-35-3 ]
[ 29739-67-1 ]

References: [1]Synthesis,1996,p. 82 - 86.

23
[ 6214-35-3 ]
[ 166986-35-2 ]
(2Z,4E)-7,7-diethoxyhepta-2,4-dienoic acid [ No CAS ]

References: [1]Synthesis,1996,p. 82 - 86.

24
[ 6214-35-3 ]
C₇H₁₁BrZn [ No CAS ]
[ 175288-15-0 ]

References: [1]Synthesis,1996,p. 82 - 86.

25
[ 6214-35-3 ]
C₄H₅BrOZn [ No CAS ]
(Z)-6-methoxyhex-2-en-4-ynoic acid [ No CAS ]

References: [1]Synthesis,1996,p. 82 - 86.

26
[ 6214-35-3 ]
zinc bromide trimethylsilylacetylide [ No CAS ]
[ 175288-16-1 ]

References: [1]Synthesis,1996,p. 82 - 86.

27
[ 6214-35-3 ]
[ 92081-13-5 ]
[ 68676-77-7 ]

References: [1]Synthesis,1996,p. 82 - 86.
[2]Synthetic Communications,1998,vol. 28,p. 239 - 249.

28
[ 6214-35-3 ]
[ 23895-60-5 ]
[ 177905-30-5 ]
[ 177905-25-8 ]

References: [1]Tetrahedron Letters,1996,vol. 37,p. 3501 - 3504.

29
[ 6214-35-3 ]
[ 536-74-3 ]
[ 35304-86-0 ]
(E)-4-[5-Oxo-5H-furan-(2Z)-ylidene]-4-phenyl-but-2-enoic acid [ No CAS ]

References: [1]Synthesis,1997,p. 121 - 128.
[2]Synthesis,1997,p. 121 - 128.

30
[ 6214-35-3 ]
[ 185198-21-4 ]
[ 208336-74-7 ]

References: [1]Journal of the American Chemical Society,1998,vol. 120,p. 3935 - 3948.

31
[ 6214-35-3 ]
[ 208336-86-1 ]
[ 208336-87-2 ]

References: [1]Journal of the American Chemical Society,1998,vol. 120,p. 3935 - 3948.

32
[ 5664-20-0 ]
[ 6214-35-3 ]
5-Cyclohexylidene-5,6-dihydro-pyran-2-one [ No CAS ]
5-Methylene-1-oxa-spiro[5.5]undec-3-en-2-one [ No CAS ]

References: [1]Journal of Organic Chemistry,1998,vol. 63,p. 2154 - 2160.

33
[ 6214-35-3 ]
[ 13169-00-1 ]
6-Methoxy-5-methylene-5,6-dihydro-pyran-2-one [ No CAS ]

References: [1]Journal of Organic Chemistry,1998,vol. 63,p. 2154 - 2160.

34
[ 6214-35-3 ]
[ 56956-46-8 ]
5-Methylene-6-octyl-5,6-dihydro-pyran-2-one [ No CAS ]
5-Non-(E)-ylidene-5,6-dihydro-pyran-2-one [ No CAS ]

References: [1]Journal of Organic Chemistry,1998,vol. 63,p. 2154 - 2160.

35
[ 471-25-0 ]
[ 6214-35-3 ]
[ 6372-02-7 ]

References: [1]Tetrahedron Letters,1998,vol. 39,p. 6719 - 6720.

Historical Records

Technical Information

• Alkyl Halide Occurrence • Arndt-Eistert Homologation • General Reactivity • Heat of Combustion • Hiyama Cross-Coupling Reaction • Hunsdiecker-Borodin Reaction • Kinetics of Alkyl Halides • Passerini Reaction • Preparation of Amines • Preparation of Carboxylic Acids • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Carboxylic Acids • Reactions of Dihalides • Schmidt Reaction • Specialized Acylation Reagents-Ketenes • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Ugi Reaction

Related Functional Groups of
[ 6214-35-3 ]

Alkenyls

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Aliphatic Chain Hydrocarbons

A168434 [6213-88-3]

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Iodides

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P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 6214-35-3

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