87860-35-3|(S)-2-Phenoxypropan-1-ol| Ambeed

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Quality Control of [ 87860-35-3 ] Purity: 95% SDS Specification

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Product Details of [ 87860-35-3 ]

CAS No. :	87860-35-3
Formula :	C₉H₁₂O₂
M.W :	152.19
SMILES Code :	C[C@@H](CO)OC1=CC=CC=C1
MDL No. :	MFCD30164055
InChI Key :	LOJHHQNEBFCTQK-QMMMGPOBSA-N
Pubchem ID :	10942641

Safety of [ 87860-35-3 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 87860-35-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 87860-35-3 ]

[ 87860-35-3 ] Synthesis Path-Downstream 1~36

1
[ 940-31-8 ]
[ 1129-46-0 ]
[ 87860-35-3 ]

References: [1]Agricultural and Biological Chemistry,1984,vol. 48,p. 1373 - 1374.

2
[ 20445-33-4 ]
[ 87860-35-3 ]
[ 97534-38-8 ]

References: [1]Helvetica Chimica Acta,1994,vol. 77,p. 502 - 508.

3
[ 39637-99-5 ]
[ 87860-35-3 ]
(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-phenoxy-propyl ester [ No CAS ]

References: [1]Helvetica Chimica Acta,1994,vol. 77,p. 502 - 508.

4
[ 76671-57-3 ]
[ 87860-35-3 ]

References: [1]Helvetica Chimica Acta,1994,vol. 77,p. 502 - 508.
[2]ACS Medicinal Chemistry Letters,2017,vol. 8,p. 925 - 930.

5
[ 98-59-9 ]
[ 87860-35-3 ]
[ 158109-37-6 ]

References: [1]Helvetica Chimica Acta,1994,vol. 77,p. 502 - 508.

6
[ 119233-39-5 ]
[ 87860-35-3 ]
[ 64658-22-6 ]

References: [1]Tetrahedron,1999,vol. 55,p. 1491 - 1504.

7
[ 221310-60-7 ]
[ 87860-35-3 ]
[ 64658-22-6 ]

References: [1]Tetrahedron,1999,vol. 55,p. 1491 - 1504.

8
[ 71159-33-6 ]
[ 87860-35-3 ]
[ 64658-22-6 ]
(R)-2-phenoxy-1-propyl acetate [ No CAS ]
[ 885610-08-2 ]

References: [1]Journal of Organic Chemistry,1999,vol. 64,p. 2638 - 2647.
[2]Tetrahedron Asymmetry,2003,vol. 14,p. 3917 - 3924.

9
[ 885610-08-2 ]
[ 87860-35-3 ]

References: [1]Journal of Organic Chemistry,1999,vol. 64,p. 2638 - 2647.

10
[ 108-05-4 ]
[ 4169-04-4 ]
[ 87860-35-3 ]
[ 64658-22-6 ]
[ 885610-08-2 ]

References: [1]Tetrahedron Asymmetry,2001,vol. 12,p. 1595 - 1602.

11
[ 105-38-4 ]
[ 4169-04-4 ]
[ 87860-35-3 ]
[ 64658-22-6 ]
Propionic acid (S)-2-phenoxy-propyl ester [ No CAS ]

References: [1]Tetrahedron Asymmetry,2001,vol. 12,p. 1595 - 1602.

12
[ 2549-51-1 ]
[ 4169-04-4 ]
[ 87860-35-3 ]
[ 64658-22-6 ]
Chloro-acetic acid (S)-2-phenoxy-propyl ester [ No CAS ]

References: [1]Tetrahedron Asymmetry,2001,vol. 12,p. 1595 - 1602.

13
[ 3050-69-9 ]
[ 4169-04-4 ]
[ 87860-35-3 ]
[ 64658-22-6 ]
Hexanoic acid (S)-2-phenoxy-propyl ester [ No CAS ]

References: [1]Tetrahedron Asymmetry,2001,vol. 12,p. 1595 - 1602.

14
[ 818-44-0 ]
[ 4169-04-4 ]
[ 87860-35-3 ]
[ 64658-22-6 ]
Octanoic acid (S)-2-phenoxy-propyl ester [ No CAS ]

References: [1]Tetrahedron Asymmetry,2001,vol. 12,p. 1595 - 1602.

15
[ 2146-71-6 ]
[ 4169-04-4 ]
[ 87860-35-3 ]
[ 64658-22-6 ]
Dodecanoic acid (S)-2-phenoxy-propyl ester [ No CAS ]

References: [1]Tetrahedron Asymmetry,2001,vol. 12,p. 1595 - 1602.

16
(+/-)-2-phenoxy-1-propyl heptanoate [ No CAS ]
[ 87860-35-3 ]
[ 64658-22-6 ]
(R)-2-phenoxy-1-propyl heptanoate [ No CAS ]
(S)-2-phenoxy-1-propyl heptanoate [ No CAS ]

References: [1]Tetrahedron Asymmetry,2003,vol. 14,p. 3917 - 3924.

17
[ 87860-35-3 ]
(1RS,2RS,2''S)-2-<4'-(2''-phenoxypropyloxy)benzyl>cyclohexan-1-ol [ No CAS ]

References: [1]Helvetica Chimica Acta,1994,vol. 77,p. 502 - 508.

18
[ 87860-35-3 ]
(1RS,2SR,2''S)-2-<4'-(2''-phenoxypropyloxy)benzyl>cyclohexan-1-ol [ No CAS ]

References: [1]Helvetica Chimica Acta,1994,vol. 77,p. 502 - 508.

19
[ 87860-35-3 ]
(2''S)-2-<4'-(2''-phenoxypropyloxy)benzyl>cyclohexan-1-one [ No CAS ]

References: [1]Helvetica Chimica Acta,1994,vol. 77,p. 502 - 508.

20
[ 87860-35-3 ]
(2''S)-2-<4'-(2''-phenoxypropyloxy)benzyl>cyclohexan-1-one ethylene acetal [ No CAS ]

References: [1]Helvetica Chimica Acta,1994,vol. 77,p. 502 - 508.

21
[ 52687-81-7 ]
[ 87860-35-3 ]
[ 64658-22-6 ]

References: [1]Advanced Synthesis and Catalysis,2009,vol. 351,p. 363 - 366.
[2]Journal of the American Chemical Society,2017,vol. 139,p. 3065 - 3071.

22
[ 1021327-16-1 ]
[ 87860-35-3 ]
[ 64658-22-6 ]

Yield	Reaction Conditions	Operation in experiment
	With Ru(H)2{(R)-Tol-BINAP{R,R}-dpen}; potassium tert-butylate; hydrogen; In tetrahydrofuran; at 22℃; under 3040.2 Torr; for 0.333333h;Glovebox;	General procedure: 0.01 mmol (8.1 mg) of RuCl2{(R,R)(Ph2PCH(Ph)CH(Me)NH2}2 (12a), and 0.15 mmol (16.8 mg) of KOtBu were weighed out into two separate NMR tubes in a glove box. 1 mL of freshly distilled THF was then added to each of the NMR tubes and then shaken to dissolve the compounds. A low-pressure glass reactor was then charged with 0.5 mmol of amide and then purged for 10 min with H2. The catalyst precursor solution was then cannulated into the reactor under H2 followed by KOtBu solution and a 2 mL THF wash. The reactor was then pressurized to 4 atm H2. The reaction was then monitored every 20 min by removing a sample and recording the 1H NMR. Several amides and catalysts have been screened using this reaction, and determined the enantiomeric excess of the product alcohols. The data obtained is summarized in table 7, below. Percentage conversion was determined by 1H NMR. Percentage enantiomeric excess (ee) was determined by HPLC using CHIRALPAK TM IB Column, reaction conditions: 4 atm H2, room temperature (22 C.), [Substrate]=0.125 M (4 mL THF).

References: [1]Patent: US2014/163225,2014,A1 .Location in patent: Paragraph 0274; 0275; 0276; 0277; 0278; 0279.
[2]Journal of the American Chemical Society,2017,vol. 139,p. 3065 - 3071.

23
[ 71159-33-6 ]
[ 87860-35-3 ]

Yield	Reaction Conditions	Operation in experiment
	With Pseudomonas cepacia lipase; In aq. phosphate buffer; isopropyl alcohol; at 27℃;pH 7.0;Resolution of racemate; Enzymatic reaction;	General procedure: 10 mL of a mixed solution of crude PcL powder (10 mg mL-1), substrate (ester of chiral primary alcohol, 100 mmol L-1) and PBS (phosphate buffer solution, 100 mmol L-1, pH 7.0, including 10% V/V isopropanol as co-solvent) was added into a 20 mL flask incubated at 27C (300 K) under 200 rpm stirring. The reaction time was controlled as the conversion ratio was between 20 and 30%. The product was extracted by an equal volume of n-octanol. Substrates with aryl groups (2-7, 10-14) were analyzed by an Agilent 1100 HPLC equipped with an Chiralpak AD-H column, whereas those without an aryl group (1, 8 and 9) were analyzed by an HP 1890 GC equipped with a Varian CP-Cyclodextrin-B-2, 3, 6-M-19 capillary GC column. The initial reaction rate = c·[Ester]0·V/Δt, where c is the conversion of the substrate, herein c should be less than 5%; [Ester]0 is the initial molar concentration of the substrate (100 mmol L-1); V is the volume of the reactant (10 mL); and Δt is the reaction time. The enantioselectivity ratio (E value) was calculated according to Chen et al. [18]: E = ln{1 - c(1 + eep)}/ln{1-c(1 - eep)}, where c is the conversion of the substrate; and eep is the enantiomer excess, eep= \|[(S)-alcohol] - [(R)-alcohol]\|/[(S)-alcohol] + [(R)-alcohol] × 100%. In the formulas, the quantity in the square brackets denotes molar concentration.

References: [1]Journal of Molecular Catalysis B: Enzymatic,2014,vol. 109,p. 109 - 115.

24
butyric acid 2-phenoxy-propyl ester [ No CAS ]
[ 87860-35-3 ]

Yield	Reaction Conditions	Operation in experiment
	With Pseudomonas cepacia lipase; In aq. phosphate buffer; isopropyl alcohol; at 27℃;pH 7.0;Resolution of racemate; Enzymatic reaction;	General procedure: 10 mL of a mixed solution of crude PcL powder (10 mg mL-1), substrate (ester of chiral primary alcohol, 100 mmol L-1) and PBS (phosphate buffer solution, 100 mmol L-1, pH 7.0, including 10% V/V isopropanol as co-solvent) was added into a 20 mL flask incubated at 27C (300 K) under 200 rpm stirring. The reaction time was controlled as the conversion ratio was between 20 and 30%. The product was extracted by an equal volume of n-octanol. Substrates with aryl groups (2-7, 10-14) were analyzed by an Agilent 1100 HPLC equipped with an Chiralpak AD-H column, whereas those without an aryl group (1, 8 and 9) were analyzed by an HP 1890 GC equipped with a Varian CP-Cyclodextrin-B-2, 3, 6-M-19 capillary GC column. The initial reaction rate = c·[Ester]0·V/Δt, where c is the conversion of the substrate, herein c should be less than 5%; [Ester]0 is the initial molar concentration of the substrate (100 mmol L-1); V is the volume of the reactant (10 mL); and Δt is the reaction time. The enantioselectivity ratio (E value) was calculated according to Chen et al. [18]: E = ln{1 - c(1 + eep)}/ln{1-c(1 - eep)}, where c is the conversion of the substrate; and eep is the enantiomer excess, eep= \|[(S)-alcohol] - [(R)-alcohol]\|/[(S)-alcohol] + [(R)-alcohol] × 100%. In the formulas, the quantity in the square brackets denotes molar concentration.

References: [1]Journal of Molecular Catalysis B: Enzymatic,2014,vol. 109,p. 109 - 115.

25
hexanoic acid 2-phenoxy-propyl ester [ No CAS ]
[ 87860-35-3 ]

Yield	Reaction Conditions	Operation in experiment
	With Pseudomonas cepacia lipase; In aq. phosphate buffer; isopropyl alcohol; at 27℃;pH 7.0;Resolution of racemate; Enzymatic reaction;	General procedure: 10 mL of a mixed solution of crude PcL powder (10 mg mL-1), substrate (ester of chiral primary alcohol, 100 mmol L-1) and PBS (phosphate buffer solution, 100 mmol L-1, pH 7.0, including 10% V/V isopropanol as co-solvent) was added into a 20 mL flask incubated at 27C (300 K) under 200 rpm stirring. The reaction time was controlled as the conversion ratio was between 20 and 30%. The product was extracted by an equal volume of n-octanol. Substrates with aryl groups (2-7, 10-14) were analyzed by an Agilent 1100 HPLC equipped with an Chiralpak AD-H column, whereas those without an aryl group (1, 8 and 9) were analyzed by an HP 1890 GC equipped with a Varian CP-Cyclodextrin-B-2, 3, 6-M-19 capillary GC column. The initial reaction rate = c·[Ester]0·V/Δt, where c is the conversion of the substrate, herein c should be less than 5%; [Ester]0 is the initial molar concentration of the substrate (100 mmol L-1); V is the volume of the reactant (10 mL); and Δt is the reaction time. The enantioselectivity ratio (E value) was calculated according to Chen et al. [18]: E = ln{1 - c(1 + eep)}/ln{1-c(1 - eep)}, where c is the conversion of the substrate; and eep is the enantiomer excess, eep= \|[(S)-alcohol] - [(R)-alcohol]\|/[(S)-alcohol] + [(R)-alcohol] × 100%. In the formulas, the quantity in the square brackets denotes molar concentration.

References: [1]Journal of Molecular Catalysis B: Enzymatic,2014,vol. 109,p. 109 - 115.

26
octanoic acid 2-phenoxy-propyl ester [ No CAS ]
[ 87860-35-3 ]

Yield	Reaction Conditions	Operation in experiment
	With Pseudomonas cepacia lipase; In aq. phosphate buffer; isopropyl alcohol; at 27℃;pH 7.0;Resolution of racemate; Enzymatic reaction;	General procedure: 10 mL of a mixed solution of crude PcL powder (10 mg mL-1), substrate (ester of chiral primary alcohol, 100 mmol L-1) and PBS (phosphate buffer solution, 100 mmol L-1, pH 7.0, including 10% V/V isopropanol as co-solvent) was added into a 20 mL flask incubated at 27C (300 K) under 200 rpm stirring. The reaction time was controlled as the conversion ratio was between 20 and 30%. The product was extracted by an equal volume of n-octanol. Substrates with aryl groups (2-7, 10-14) were analyzed by an Agilent 1100 HPLC equipped with an Chiralpak AD-H column, whereas those without an aryl group (1, 8 and 9) were analyzed by an HP 1890 GC equipped with a Varian CP-Cyclodextrin-B-2, 3, 6-M-19 capillary GC column. The initial reaction rate = c·[Ester]0·V/Δt, where c is the conversion of the substrate, herein c should be less than 5%; [Ester]0 is the initial molar concentration of the substrate (100 mmol L-1); V is the volume of the reactant (10 mL); and Δt is the reaction time. The enantioselectivity ratio (E value) was calculated according to Chen et al. [18]: E = ln{1 - c(1 + eep)}/ln{1-c(1 - eep)}, where c is the conversion of the substrate; and eep is the enantiomer excess, eep= \|[(S)-alcohol] - [(R)-alcohol]\|/[(S)-alcohol] + [(R)-alcohol] × 100%. In the formulas, the quantity in the square brackets denotes molar concentration.

References: [1]Journal of Molecular Catalysis B: Enzymatic,2014,vol. 109,p. 109 - 115.

27
dodecanoic acid 2-phenoxy-propyl ester [ No CAS ]
[ 87860-35-3 ]

Yield	Reaction Conditions	Operation in experiment
	With Pseudomonas cepacia lipase; In aq. phosphate buffer; isopropyl alcohol; at 27℃;pH 7.0;Resolution of racemate; Enzymatic reaction;	General procedure: 10 mL of a mixed solution of crude PcL powder (10 mg mL-1), substrate (ester of chiral primary alcohol, 100 mmol L-1) and PBS (phosphate buffer solution, 100 mmol L-1, pH 7.0, including 10% V/V isopropanol as co-solvent) was added into a 20 mL flask incubated at 27C (300 K) under 200 rpm stirring. The reaction time was controlled as the conversion ratio was between 20 and 30%. The product was extracted by an equal volume of n-octanol. Substrates with aryl groups (2-7, 10-14) were analyzed by an Agilent 1100 HPLC equipped with an Chiralpak AD-H column, whereas those without an aryl group (1, 8 and 9) were analyzed by an HP 1890 GC equipped with a Varian CP-Cyclodextrin-B-2, 3, 6-M-19 capillary GC column. The initial reaction rate = c·[Ester]0·V/Δt, where c is the conversion of the substrate, herein c should be less than 5%; [Ester]0 is the initial molar concentration of the substrate (100 mmol L-1); V is the volume of the reactant (10 mL); and Δt is the reaction time. The enantioselectivity ratio (E value) was calculated according to Chen et al. [18]: E = ln{1 - c(1 + eep)}/ln{1-c(1 - eep)}, where c is the conversion of the substrate; and eep is the enantiomer excess, eep= \|[(S)-alcohol] - [(R)-alcohol]\|/[(S)-alcohol] + [(R)-alcohol] × 100%. In the formulas, the quantity in the square brackets denotes molar concentration.

References: [1]Journal of Molecular Catalysis B: Enzymatic,2014,vol. 109,p. 109 - 115.

28
2-phenoxy-1-(1-piperidinyl)-1-propanone [ No CAS ]
[ 87860-35-3 ]
[ 64658-22-6 ]

References: [1]Journal of the American Chemical Society,2017,vol. 139,p. 3065 - 3071.

29
isopropyl 2-phenoxypropanoate [ No CAS ]
[ 87860-35-3 ]
[ 64658-22-6 ]

References: [1]Journal of the American Chemical Society,2017,vol. 139,p. 3065 - 3071.

30
[ 2065-24-9 ]
[ 87860-35-3 ]
[ 64658-22-6 ]

References: [1]Journal of the American Chemical Society,2017,vol. 139,p. 3065 - 3071.

31
[ 122-35-0 ]
[ 87860-35-3 ]
[ 64658-22-6 ]

References: [1]Journal of the American Chemical Society,2017,vol. 139,p. 3065 - 3071.
[2]Journal of the American Chemical Society,2017,vol. 139,p. 3065 - 3071.

32
rac-2-phenoxy-1-(morpholine)-1-propanone [ No CAS ]
[ 87860-35-3 ]
[ 64658-22-6 ]

References: [1]Journal of the American Chemical Society,2017,vol. 139,p. 3065 - 3071.

33
1-(4-fluorophenyl)-4-hydroxypyridin-2(1H)-one [ No CAS ]
[ 87860-35-3 ]
(S)-1-(4-fluorophenyl)-4-(2-phenoxypropoxy)pyridin-2(1H)-one [ No CAS ]

References: [1]ACS Medicinal Chemistry Letters,2017,vol. 8,p. 925 - 930.

34
[ 108-95-2 ]
[ 87860-35-3 ]

References: [1]ACS Medicinal Chemistry Letters,2017,vol. 8,p. 925 - 930.

35
isopropyl (S)-2-(tert-butoxy)-2-(4‘-(4,4-dimethylpiperidin-1-yl)-5-hydroxy-6’-methyl-[2,3‘-bipyridin]-5‘-yl)acetate [ No CAS ]
[ 87860-35-3 ]
isopropyl (S)-2-(tert-butoxy)-2-(4'-(4,4-dimethylpiperidin-1-yl)-6'-methyl-5-((S)-2-phenoxypropoxy)-[2,3'-bipyridin]-5'-yl)acetate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
12.99%	With diisopropyl (E)-azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20℃;	To a stiired solution of isopropyl (S)-2-(tert-butoxy)-2-(4'-(4,4- dimethylpiperidin-l-yl)-5-hydroxy-6'-methyl-[2,3'-bipyridin]-5'-yl)acetate (60 mg, 0.128 mmol), (S)-2-phenoxypropan-l-ol (38.9 mg, 0.256 mmol) and triphenylphosphine (67.0 mg, 0.256 mmol) in THF (5 mF) was added diisopropyl diazene-l,2-dicarboxylate (51.7 mg, 0.256 mmol) at 0 C. Then, the reaction mixture was stirred at rt overnight and solvent was removed under reduced pressure. H2O (100 ml) and ethyl acetate (150 mF) were added. The organic layer was separated, dried over Na2SC>4, and concentrated. The residue was purified by prep-TLC (pet. ether/EtOAc; 2: 1) to afford isopropyl (S)-2-(tert-butoxy)-2-(4'-(4,4- dimethylpiperidin-l-yl)-6'-methyl-5-((S)-2-phenoxypropoxy)-[2,3'-bipyridin]-5'-yl)acetate (10 mg, 0.016 mmol, 12.99 % yield) as a yellow oil. LC-MS: 604.2 [M+H], Retention time (0.01% NH4HCO3) = 2.66 min.

References: [1]Patent: WO2019/244066,2019,A2 .Location in patent: Page/Page column 164; 165.

36
isopropyl (S)-2-(tert-butoxy)-2-(4-(4,4-dimethylpiperidin-1-yl)-6’-fluoro-6-methyl-[3,3’-bipyridin]-5-yl)acetate [ No CAS ]
[ 87860-35-3 ]
(S)-2-(tert-butoxy)-2-(4-(4,4-dimethylpiperidin-1-yl)-6-methyl-6’-((S)-2-phenoxypropoxy)-[3,3’-bipyridin]-5-yl)acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
25.2%	With sodium hydride; In N,N-dimethyl-formamide; at 20℃; for 16.0h;	To an ice-cooled solution of (S)-2-phenoxypropan-l-ol (1 1.29 mg, 0.074 mmol) in DMF (3 mF) was added the NaH (8.90 mg, 0.223 mmol) in one portion. Isopropyl (S)-2- (tert-butoxy)-2-(4-(4,4-dimethylpiperidin-l-yl)-6'-fluoro-6-methyl-[3,3'-bipyridin]-5- yl)acetate (35 mg, 0.074 mmol) in DMF (1 mF) was added and the mixture was stirred at rt for addtional 16 h. Then, pH was adjusted to ~7 with 1N HC1. The mixture was filtered and subjected to prep-HPFC purification {Instrument Gilson 281 (PHG-009; Column: Xtimate Prep C18 OBD, 2l .2x 250 mm, 10 pm; Mobile Phase A: Water (10 mmol NH4HCO3); B: MeCN; Gradient: 55-63%B in 8.0 min, stop at 13.0 min;Flow Rate (ml/min) 30.00} to give the desired product (S)-2-(tert-butoxy)-2-(4-(4,4-dimethylpiperidin-l-yl)-6-methyl-6'-((S)-2- phenoxypropoxy)-[3,3'-bipyridin]-5-yl)acetic acid (10.8 mg, 0.019 mmol, 25.2 % yield). FC- MS: 562.3 [M+H], Retention time (0.0l% NH4HCC>3) = 1.62 min. NMR (400 MHz, MeOD) d 8.27-8.04 (m, 2H), 7.69-7.68 (m, 1H), 7.28 (t, J= 8.0 Hz, 2H), 7.11-6.79 (m, 4H), 5.77 (s, 1H), 4.90-4.86 (m, 1H), 4.57 (dd, J= 11.2, 6.2 Hz, 1H), 4.46 (dd, = 11.2, 6.2 Hz, 1H), 3.15-3.14 (m, 2H), 2.74-2.73 (m, 2H), 2.66 (s, 3H), 1.45-1.43 (m, 7H), 1.21 (s, 9H), 0.91 (s, 6H).

References: [1]Patent: WO2019/244066,2019,A2 .Location in patent: Page/Page column 163; 164.

Historical Records

Technical Information

• Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Friedel-Crafts Reaction • Hydrogenolysis of Benzyl Ether • Preparation of Alkylbenzene • Reactions of Benzene and Substituted Benzenes • Vilsmeier-Haack Reaction

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P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 87860-35-3

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CAS No.: 87860-35-3

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[ 87860-35-3 ] Synthesis Path-Downstream 1~36

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