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Chemical Structure| 520-30-9 Chemical Structure| 520-30-9

Structure of Norartocarpetin
CAS No.: 520-30-9

Chemical Structure| 520-30-9

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Norartocarpetin is a tyrosinase inhibitor with strong inhibitory activity (IC50 of 0.47 μM). It can be used as an anti-browning agent in food systems and shows significant anticancer activity against lung cancer cells (NCI-H460) with an IC50 of 22 μM.

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Product Citations

Product Citations

Zhao, Li ; Liao, Juan ; Zhao, Haijiao ; Feng, Cuiping ;

Abstract: This study systematically analyzed metabolite changes in quinoa after lactic acid bacteria (LAB) fermentation and the hypoglycemic mechanism of key metabolites inhibiting α-glucosidase. Mixed LAB fermentation significantly altered the metabolic profile of quinoa, and a total of 627 differential metabolites were identified, among which 471 were significantly up-regulated. After fermentation, the levels of flavonoids, phenolic acids, and amino acid derivatives increased significantly, and five new flavonoid metabolites were detected. The polyphenol extract from fermented quinoa (FQP) significantly inhibited α-glucosidase activity, with an IC₅₀ value of 0.17 mg/mL. Mechanistic studies indicated that FQP exerted mixed-type reversible inhibition, forming hydrogen bonds, van der Waals forces, and hydrophobic interactions with amino acid residues in the active center of α-glucosidase. These interactions induced conformational changes in the enzyme, thereby reducing its catalytic efficiency. This research provides a theoretical basis for the functional processing of quinoa and the development of novel hypoglycemic functional factors.

Keywords: Fermented quinoa ; Widely targeted metabolomics ; α-Glucosidase inhibition ; Hypoglycemic mechanisms ; Polyphenols

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Product Details of Norartocarpetin

CAS No. :520-30-9
Formula : C15H10O6
M.W : 286.24
SMILES Code : O=C1C=C(C2=C(O)C=C(O)C=C2)OC3=C1C(O)=CC(O)=C3
MDL No. :MFCD18450746

Safety of Norartocarpetin

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Related Pathways of Norartocarpetin

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1 mM

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3.49mL

0.70mL

0.35mL

17.47mL

3.49mL

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34.94mL

6.99mL

3.49mL

 

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