CAS No. :	72040-64-3
Formula :	C₁₆H₂₇N₃O₄S
M.W :	357.47
SMILES Code :	O=C(O)CCCCCNC(CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O)=O
Synonyms :	N-(+)-Biotinyl-6-aminohexanoic acid
MDL No. :	MFCD00144853
InChI Key :	CMUGHZFPFWNUQT-HUBLWGQQSA-N
Pubchem ID :	446905

Safety of N-Biotinyl-6-aminohexanoic acid

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of N-Biotinyl-6-aminohexanoic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 72040-64-3 ]

[ 72040-64-3 ] Synthesis Path-Downstream 1~54

1
12-aminododecanoic acid methyl ester hydrochloride [ No CAS ]
[ 72040-64-3 ]
[ 223733-85-5 ]

References: [1]Journal of Medicinal Chemistry,1999,vol. 42,p. 1836 - 1841.

2
[ 170892-94-1 ]
[ 72040-64-3 ]
Biotinylaminocaproyl-L-methionylglycyl-L-leucyl-L-prolyl-(S-farnesyl)-L-cysteine methyl ester [ No CAS ]

References: [1]Chemistry - A European Journal,1999,vol. 5,p. 1239 - 1252.

3
Glycyl-(S-palmitoyl)-L-cysteine allyl ester hydrotrifluoroacetate [ No CAS ]
[ 72040-64-3 ]
Biotinylaminocaproyl-glycyl-(S-palmitoyl)-L-cysteine allyl ester [ No CAS ]

References: [1]Chemistry - A European Journal,1999,vol. 5,p. 1239 - 1252.

4
[ 72040-64-3 ]
Glycyl-(S-hexadecyl)-L-cysteine allyl ester hydrotrifluoroacetate [ No CAS ]
Biotinylaminocaproyl-glycyl-(S-hexadecyl)-L-cysteine allyl ester [ No CAS ]

References: [1]Chemistry - A European Journal,1999,vol. 5,p. 1239 - 1252.

5
[ 72040-64-3 ]
poly(sebacic acid) [ No CAS ]
fluorescein-conjugated avidin [ No CAS ]
6-((biotinoyl)amino)hexanoic acid-attached poly(sebacic acid) microspheres [ No CAS ]

References: [1]Journal of Pharmaceutical Sciences,1998,vol. 87,p. 246 - 248.

6
methyl 6-(+)-biotinylamidohexanoate [ No CAS ]
[ 72040-64-3 ]

Yield	Reaction Conditions	Operation in experiment
58.3%	With lithium hydroxide monohydrate; In methanol;Reflux;	Lithium hydroxide (4equiv) solution was added to 6 (1equiv) dissolved in methanol. The solution was heated to reflux overnight. The product 7 was precipitated as white solid. Then a hydrochloric acid solution (6 N) was added until the pH was 5. The product was filtered, and dried under vacuum.

References: [1]Journal of labelled compounds and radiopharmaceuticals,2000,vol. 43,p. 309 - 322.
[2]Bioorganic and Medicinal Chemistry Letters,2017,vol. 27,p. 3591 - 3594.
[3]Organic and Biomolecular Chemistry,2016,vol. 14,p. 7676 - 7690.

7
[ 4136-95-2 ]
[ 72040-64-3 ]
C₂₃H₂₈Cl₃N₃O₅S [ No CAS ]

References: [1]Tetrahedron,2000,vol. 56,p. 9625 - 9632.

8
[ 162827-97-6 ]
[ 72040-64-3 ]
[ 721431-24-9 ]

References: [1]Journal of Organic Chemistry,2004,vol. 69,p. 4375 - 4380.

9
[ 66534-97-2 ]
[ 72040-64-3 ]
5-(2-oxohexahydrothieno[3,4-d]imidazol-6-yl)pentanoic acid {5-[bis(2-diphenylphosphanyl-ethyl)carbamoyl]pentyl}amide [ No CAS ]

References: [1]Journal of the American Chemical Society,2004,vol. 126,p. 14411 - 14418.

10
[ 144085-40-5 ]
[ 72040-64-3 ]
6-[5-(2-oxohexahydrothieno[3,4-d]imidazol-4-yl)pentanoylamino]hexanoic acid {3-diphenylphosphanyl-2-[(diphenylphosphanyl)methyl]-2-methylpropyl}amide [ No CAS ]

References: [1]Journal of the American Chemical Society,2004,vol. 126,p. 14411 - 14418.

11
[ 72040-64-3 ]
[ 774183-16-3 ]
methyl 2-cyano-23-[6-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)hexanoyl]oxy-3,12-dioxooleana-1,9⁽¹¹⁾-dien-28-oate [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2004,vol. 47,p. 4923 - 4932.

12
[ 58-85-5 ]
[ 60-32-2 ]
[ 72040-64-3 ]

References: [1]Journal of the American Chemical Society,2004,vol. 126,p. 14411 - 14418.

13
[ 7689-03-4 ]
[ 72040-64-3 ]
6-biotinylaminocaproic acid-(20s)-camptothecin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
39%	With dmap; diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 20℃; for 48h;Inert atmosphere;	General procedure: To a mixture of Biotin or 6-biotinylaminocaproic acid (0.3 mmol), camptothecin analogues (0.1 mmol) and DMF (2.5 mL) was added, 4-Dimethylaminopyridine (DMAP) (0.01 mmol) was added and N, N'-Diisopropylcarbodiimide) (DIC) (0.6 mmol) dropwise. The reaction mixture was stirred at room temperature for 2 days under N2. Solvent were removed under a reduced. The residue was purified on a silica gel chromatography (CHCl3:CH3OH = 15:1?9:1) to afford the product Biotin-(20s)-camptothecin (11). Yellow amorphous powder, yield 60percent;

References: [1]Bioorganic and Medicinal Chemistry Letters,2019,vol. 29,p. 234 - 237.
[2]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 4846 - 4849.

14
glycine rapamycin ester [ No CAS ]
[ 72040-64-3 ]
C₆₉H₁₀₇N₅O₁₇S [ No CAS ]

References: [1]Journal of the American Chemical Society,2005,vol. 127,p. 4715 - 4721.

15
[ 56-41-7 ]
[ 72040-64-3 ]
(S)-2-{6-[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-hexanoylamino}-propionic acid [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 927 - 933.

16
[ 61-90-5 ]
[ 72040-64-3 ]
(S)-4-Methyl-2-{6-[5-((3aR,6S,6aS)-2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-hexanoylamino}-pentanoic acid [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 927 - 933.

17
[ 63-68-3 ]
[ 72040-64-3 ]
[ 217655-55-5 ]

References: [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 927 - 933.

18
[ 56-85-9 ]
[ 72040-64-3 ]
(S)-4-Carbamoyl-2-{6-[5-((3aR,6S,6aS)-2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-hexanoylamino}-butyric acid [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 927 - 933.

19
[ 74-79-3 ]
[ 72040-64-3 ]
(S)-5-Guanidino-2-{6-[5-((3aR,6S,6aS)-2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-hexanoylamino}-pentanoic acid [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 927 - 933.

20
[ 63-91-2 ]
[ 72040-64-3 ]
(S)-2-{6-[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-hexanoylamino}-3-phenyl-propionic acid [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 927 - 933.

21
[ 912557-14-3 ]
[ 72040-64-3 ]
[(S)-2-((S)-3-Methyl-2-{6-[5-((3aR,6S,6aS)-2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-hexanoylamino}-butyrylamino)-propionylamino]-acetic acid (2E,4E)-hexa-2,4-dienyl ester [ No CAS ]

References: [1]Chemistry - A European Journal,2006,vol. 12,p. 6095 - 6109.

22
[ 861640-70-2 ]
[ 72040-64-3 ]
[ 861640-71-3 ]

References: [1]Bioorganic and Medicinal Chemistry,2005,vol. 13,p. 4200 - 4208.

23
p-aminophenyl 5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-nonulosyl-2-onic acid-(2->3)-β-D-galactopyranoside-(1->4)-2-acetamido-2-deoxy-β-D-glucopyranoside [ No CAS ]
[ 72040-64-3 ]
[(6-biotinylamido)hexanoylamido]-phenyl 5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-nonulosyl-2-onic acid-(2->3)-β-D-galactopyranoside-(1->4)-2-acetamido-2-deoxy-β-D-glucopyranoside [ No CAS ]

References: [1]Carbohydrate Research,2007,vol. 342,p. 1244 - 1248.

24
p-aminophenyl 5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-nonulosyl-2-onic acid-(2->6)-β-D-galactopyranoside-(1->4)-2-acetamido-2-deoxy-β-D-glucopyranoside [ No CAS ]
[ 72040-64-3 ]
[(6-biotinylamido)hexanoylamido]-phenyl 5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-nonulosyl-2-onic acid-(2->6)-β-D-galactopyranoside-(1->4)-2-acetamido-2-deoxy-β-D-glucopyranoside [ No CAS ]

References: [1]Carbohydrate Research,2007,vol. 342,p. 1244 - 1248.

25
C₂₁H₂₂N₂O₂ [ No CAS ]
[ 72040-64-3 ]
C₃₇H₄₇N₅O₅S [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2007,vol. 17,p. 4703 - 4707.

26
[ 72040-64-3 ]
(S)-4-Methylsulfanyl-2-{6-[5-((3aR,6S,6aS)-2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-hexanoylamino}-butyric acid 4-nitro-phenyl ester [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 927 - 933.

27
[ 72040-64-3 ]
(S)-4-Methylsulfanyl-2-{6-[5-((3aR,6S,6aS)-2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-hexanoylamino}-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 927 - 933.

28
[ 72040-64-3 ]
[ 446878-26-8 ]

References: [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 927 - 933.

29
[ 72040-64-3 ]
[ 446878-23-5 ]

References: [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 927 - 933.

30
[ 72040-64-3 ]
[ 446878-21-3 ]

References: [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 927 - 933.

31
[ 72040-64-3 ]
[ 446878-22-4 ]

References: [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 927 - 933.

32
[ 72040-64-3 ]
[ 446878-24-6 ]

References: [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 927 - 933.

33
[ 72040-64-3 ]
14-hydroxy-3β-{6-[5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido]hexanoyloxy}-5β,14β-card-20(22)-enolide [ No CAS ]

References: [1]Tetrahedron,2000,vol. 56,p. 9625 - 9632.

34
[ 72040-64-3 ]
22-(4-benzoylbenzoyloxy)-14-hydroxy-3β-{6-[5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido]hexanoyloxy}-5β,14β-card-20(22)-enolide [ No CAS ]

References: [1]Tetrahedron,2000,vol. 56,p. 9625 - 9632.

35
[ 120550-35-8 ]
[ 72040-64-3 ]

References: [1]Journal of labelled compounds and radiopharmaceuticals,2000,vol. 43,p. 309 - 322.

36
[ 1926-80-3 ]
[ 72040-64-3 ]

References: [1]Journal of labelled compounds and radiopharmaceuticals,2000,vol. 43,p. 309 - 322.
[2]Bioorganic and Medicinal Chemistry Letters,2017,vol. 27,p. 3591 - 3594.

37
[ 72040-64-3 ]
[ 223733-86-6 ]

References: [1]Journal of Medicinal Chemistry,1999,vol. 42,p. 1836 - 1841.

38
[ 72040-64-3 ]
1-O-(α-D-galactopyranosyl)-2-<N-12-(6-(biotinoylamino)hexanoylamino)dodecanoylamino>-octadecanol [ No CAS ]

References: [1]Journal of Medicinal Chemistry,1999,vol. 42,p. 1836 - 1841.

39
[ 72040-64-3 ]
(2S,3R)-1-O-(α-D-galactopyranosyl)-2-<N-12-(6-(biotinoylamino)hexanoylamino)dodecanoylamino>-1,3-octadecanediol [ No CAS ]

References: [1]Journal of Medicinal Chemistry,1999,vol. 42,p. 1836 - 1841.

40
[ 72040-64-3 ]
(2S,3S,4R)-1-O-(β-D-galactopyranosyl)-2-<N-12-(6-(biotinoylamino)hexanoylamino)dodecanoylamino>-1,3,4-octadecanetriol [ No CAS ]

References: [1]Journal of Medicinal Chemistry,1999,vol. 42,p. 1836 - 1841.

41
[ 72040-64-3 ]
(2S,3S,4R)-1-O-(α-D-galactopyranosyl)-2-<N-12-(6-(biotinoylamino)hexanoylamino)dodecanoylamino>-1,3,4-octadecanetriol [ No CAS ]

References: [1]Journal of Medicinal Chemistry,1999,vol. 42,p. 1836 - 1841.

42
[ 648903-77-9 ]
[ 72040-64-3 ]
2-{4-[6-(biotinamido)hexanamido]phenylamino}-6-(2,6-dichlorophenyl)-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;N,N-dimethyl-formamide; In dichloromethane; for 12h;	2- (4-AMINOPHENYLAMINO)-6- (2, 6-DICHLOROPHENYL)-8-METHYL-8H-PYRIDO [2, 3-D] PYRIMIDIN-7- one, SKI DV1-10, (55 mg, 0.133 mmol), N- (+)-BIOTINYL-6-AMINOCAPROIC acid (57.2 mg, 0.160 mmol), 1- [3- (DIMETHYLAMINO) PROPYL]-3-ETHYLCARBODIIMIDE hydrochloride (123 mg, 0.64 mmol), and 4-dimethylaminopyridine (78 mg, 0.64 mmol) were combined in a 10 mL flame-dried round bottomed flask under argon. The solids were suspended in 5 mL of methylene chloride and a few drops of dimethylformamide. The solution was stirred for 12 hours. The reaction was poured into a separatory funnel containing 50 mL of methylene chloride. The organic layer was washed with three 50 mL portions of water and once with 50 mL of saturated brine. The organic layer was dried over magnesium sulfate, the drying agent removed by filtration and the solvent removed. The crude residue was purified by gradient silica gel column chromatography (0-15 percent 7M ammonia/ methanol in methylene chloride). The product containing fractions were combined and evaporated. The product was pure by standard analytical techniques.

References: [1]Patent: WO2004/63195,2004,A1 .Location in patent: Page 58.

43
[ 883720-36-3 ]
[ 72040-64-3 ]
[ 883720-37-4 ]

Yield	Reaction Conditions	Operation in experiment
73.4%	With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃; for 0.5h;	Benzophenone-biotin: N-(+)-Biotinyl-6-aminohexanoic acid (239 mg) and 4~benzoyl-L-phenylalanyl-6-aminoxehanoic acid methyl ester (237 mg) were dissolved in DMF, 230 mul of DIPEA were added to the reaction mixture, followed by 237 mg of HBTU. The reaction mixture was stirred at RT for 30 min. LC-MS analysis showed complete reaction. The solvent and excess of DIPEA were removed under high vacuum. The crude product was dissolved in CHCl3 and extracted 2X with 1percent HCl. Organic phase was separated, solvent was removed and the product was purified using rotary chromatography (SiO2 solid phase). Yield 325 mg (73.4percent).

References: [1]Patent: WO2007/41341,2007,A2 .Location in patent: Page/Page column 68.

44
[ 72040-64-3 ]
[ 518-28-5 ]
[ 1041187-72-7 ]

References: [1]Bioorganic and Medicinal Chemistry,2008,vol. 16,p. 5815 - 5825.

45
[ 5680-79-5 ]
[ 72040-64-3 ]
C₁₉H₃₂N₄O₅S [ No CAS ]

References: [1]Angewandte Chemie - International Edition,2008,vol. 47,p. 7119 - 7122.

46
[ 1176084-23-3 ]
[ 1176084-10-8 ]
[ 72040-64-3 ]
C₁₃₃H₂₅₄N₂₂O₄₆S₆ [ No CAS ]

References: [1]Journal of the American Chemical Society,2009,vol. 131,p. 11683 - 11685.

47
C₃₀H₃₅N₂O₄Pol [ No CAS ]
[ 72040-64-3 ]
C₄₆H₆₀N₅O₇PolS [ No CAS ]

References: [1]Chemical Communications,2009,p. 5030 - 5032.

48
C₃₇H₃₉N₂O₅Pol [ No CAS ]
[ 72040-64-3 ]
C₅₃H₆₄N₅O₈PolS [ No CAS ]

References: [1]Chemical Communications,2009,p. 5030 - 5032.

49
C₃₀H₃₄ClN₂O₄Pol [ No CAS ]
[ 72040-64-3 ]
C₄₆H₅₉ClN₅O₇PolS [ No CAS ]

References: [1]Chemical Communications,2009,p. 5030 - 5032.

50
C₃₁H₃₇N₂O₅Pol [ No CAS ]
[ 72040-64-3 ]
C₄₇H₆₂N₅O₈PolS [ No CAS ]

References: [1]Chemical Communications,2009,p. 5030 - 5032.

51
C₃₂H₃₉N₂O₄Pol [ No CAS ]
[ 72040-64-3 ]
C₄₈H₆₄N₅O₇PolS [ No CAS ]

References: [1]Chemical Communications,2009,p. 5030 - 5032.

52
C₃₁H₃₄N₃O₄Pol [ No CAS ]
[ 72040-64-3 ]
C₄₇H₅₉N₆O₇PolS [ No CAS ]

References: [1]Chemical Communications,2009,p. 5030 - 5032.

53
C₃₀H₃₄ClN₂O₅Pol [ No CAS ]
[ 72040-64-3 ]
C₄₆H₅₉ClN₅O₈PolS [ No CAS ]

References: [1]Chemical Communications,2009,p. 5030 - 5032.

54
C₃₃H₃₆N₃O₄Pol [ No CAS ]
[ 72040-64-3 ]
C₄₉H₆₁N₆O₇PolS [ No CAS ]

References: [1]Chemical Communications,2009,p. 5030 - 5032.

Historical Records

Technical Information

• Acyl Group Substitution • Arndt-Eistert Homologation • Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Chan-Lam Coupling Reaction • Complex Metal Hydride Reductions • Hunsdiecker-Borodin Reaction • Hydride Reductions • Lawesson's Reagent • Leuckart-Wallach Reaction • Mannich Reaction • Passerini Reaction • Petasis Reaction • Preparation of Amines • Preparation of Carboxylic Acids • Reactions of Amines • Reactions of Carboxylic Acids • Schmidt Reaction • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Specialized Acylation Reagents-Ketenes • Specialized Acylation Reagents-Vilsmeier Reagent • Ugi Reaction

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Code	Phrase
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P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 72040-64-3

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CAS No.: 72040-64-3

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