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Chemical Structure| 3380-34-5 Chemical Structure| 3380-34-5

Structure of Triclosan
CAS No.: 3380-34-5

Chemical Structure| 3380-34-5

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Triclosan is an antibacterial and antifungal agent present in some consumer products.

Synonyms: Irgasan; Cloxifenolum

4.5 *For Research Use Only !

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Product Citations

Product Citations      Show More

Yaneth Cardona ; Agnieszka Węgrzyn ; Paweł Miśkowiec ; Sophia A. Korili ; Antonio Gil ;

Abstract: The presence of emerging pollutants (EPs) in water is a major environmental concern. This study evaluates for the first time the removal of three EPs, namely triclosan (TCS), 2,6-dichlorophenol (2,6-DCP), and bisphenol A (BPA), 90 μmol/dm3, from water through both Fenton- and photo-Fenton-like reactions using montmorillonite (Mt) and aluminum interlayered pillared clays (Al-PILC) as catalytic supports. The catalysts (Fe2O3/TiO2/Mt and Fe2O3/TiO2/Al-PILC) were evaluated in single-component solutions and in an equimolar mixture. Two Al-PILC were synthesized from a hazardous waste, namely aluminum saline slag, using either the acid (Al-PILCAE) or the alkaline (Al-PILCBE) aluminum extract as precursors. The third Al-PILC was obtained by the conventional method using a commercial aluminum salt (Al-PILCCM). Catalytic supports were impregnated at 10 and 20 wt% titanium. Iron loadings from 1 to 20 wt% were tested for Mt, while only 20 wt% iron was tested for Al-PILC. All catalysts were characterized using several techniques and the results confirmed the formation of TiO2 and Fe2O3. Almost 100 % of TCS and 2,6-DCP were removed by both Fenton-like (240 and 420 min, respectively) and photo-Fenton-like reactions (30 and 90–120 min, respectively) using the Al-PILC based catalyst. The maximum removal for BPA was 80.14 ± 1.93 % after 120 min under photo-Fenton-like conditions using Al-PILCBE. The catalysts synthesized using the four catalytic supports showed good results for the removal of TCS by both processes, while for 2,6-DCP and BPA the best results were obtained using Al-PILCAE and Al-PILCBE as catalytic supports. Finally, a degradation pathway was suggested for every pollutant based on the by-products identified during the reactions by HPLC-MS. The results revealed that the materials used in this work are suitable catalysts for removing emerging pollutants from water by both Fenton- and photo-Fenton-like reactions.

Keywords: Photo-Fenton-like reaction ; Alumina-pillared clay ; Catalyst ; Aluminum saline slag ; Organic pollutant

Purchased from AmBeed:

Berg, Kaja ; Hegde, Pooja ; Pujari, Venugopal ; Brinkmann, Marzena ; Wilkins, David Z. ; Parish, Tanya , et al.

Abstract: The electron transport chain (ETC) in the cell membrane consists of a series of redox complexes that transfer electrons from electron donors to acceptors and couples this electron transfer with the transfer of protons (H+) across a membrane. This process generates proton motive force which is used to produce ATP and a myriad of other functions and is essential for the long-term survival of Mycobacterium tuberculosis (Mtb), the causative organism of tuberculosis (TB), under the hypoxic conditions present within infected granulomas. Menaquinone (MK), an important carrier molecule within the mycobacterial ETC, is synthesized de novo by a cluster of enzymes known as the classic/canonical MK biosynthetic pathway. MenA (1,4-dihydroxy-2-naphthoate prenyltransferase), the antepenultimate enzyme in this pathway, is a verified target for TB therapy. In this study, we explored structure-activity relationships of a previously discovered MenA inhibitor scaffold, seeking to improve potency and drug disposition properties. Focusing our campaign upon three molecular regions, we identified two novel inhibitors with potent activity against MenA and Mtb (IC50 = 13-22 μM, GIC50 = 8-10 μM). These analogs also displayed substantially improved pharmacokinetic parameters and potent synergy with other ETC-targeting agents, achieving nearly complete sterilization of Mtb in combination therapy within two weeks in vivo. These new inhibitors of MK biosynthesis present a promising new strategy to curb the continued spread of TB.

Keywords: 1,4-dihydroxy-2-naphthoate prenyltransferase ; MenA ; MenA inhibitors ; Menaquinone ; Mtb ; Mycobacterium tuberculosis ; Piperidine derivatives ; SAR

Alternative Products

Product Details of Triclosan

CAS No. :3380-34-5
Formula : C12H7Cl3O2
M.W : 289.54
SMILES Code : C1=CC(=CC(=C1OC2=CC=C(C=C2Cl)Cl)O)Cl
Synonyms :
Irgasan; Cloxifenolum
MDL No. :MFCD00800992
InChI Key :XEFQLINVKFYRCS-UHFFFAOYSA-N
Pubchem ID :5564

Safety of Triclosan

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02437578 - Active, not recruiting April 2019 Denmark ... More >> Dansk Fertilitetsklinik Frederiksberg, Denmark, 2000 Less <<
NCT01778868 - Unknown July 2013 Belgium ... More >> University Hospital Antwerp Edegem, Antwerpen, Belgium, 2650 Less <<
NCT00631566 HIV Infections ... More >> Staphylococcal Infections Less << Not Applicable Completed - United States, California ... More >> Naval Medical Center San Diego/Infectious Disease Division San Diego, California, United States, 92134-1201 United States, Maryland Walter Reed National Military Medical Center Bethesda, Maryland, United States, 20889 United States, Texas San Antonio Military Medical Center (BAMC/WHMC) San Antonio, Texas, United States, 78236-9908 United States, Virginia Naval Medical Center Portsmouth Portsmouth, Virginia, United States, 23708-2197 Less <<
NCT02080273 Dental Plaque ... More >> Gingivitis Less << Phase 4 Completed - Thailand ... More >> Mahidol University Ratchatevi, Bangkok, Thailand, 10400 Less <<
NCT00631566 - Completed - -
NCT02394821 Neoplasm Woun... More >>ds and Injuries Less << Phase 3 Completed - Brazil ... More >> EEUSP São Paulo, Brazil, 01509-900 Less <<
NCT01710878 Abdominal Aorta Aneurysm Not Applicable Completed - France ... More >> CHRU Angers, France CHU Jean Minjoz Besançon, France CHU Dupuytren Limoges, France Hôpital Edouard Herriot Lyon, France Hôpital G. et R. Laennec Nantes, France Hôpital Pompidou Paris, France CHU La Milétrie Poitiers, France Germany Krankenhaus Nordwest Frankfurt, Germany Less <<
NCT00830271 Breast Cancer Surgery Phase 4 Completed - United Kingdom ... More >> Cardiff and Vale NHS Trust Cardiff, Wales, United Kingdom, CF14 4XN Less <<
NCT01540279 - Terminated(insufficient enroll... More >>ment) Less << - Switzerland ... More >> Surgical Department of University Hospital Basel, Switzerland Basel, Basel-Stadt, Switzerland, 4031 Less <<
NCT02648139 Gingivitis Phase 1 Phase 2 Completed - -
NCT01245829 Cross Infection ... More >> Infection Control Less << Not Applicable Unknown March 2011 United Kingdom ... More >> Darlington Memorial Hospital Not yet recruiting Darlington, County Durham, United Kingdom, DL3 6HX Less <<
NCT00765167 Dental Plaque Phase 3 Completed - United States, New Jersey ... More >> UMDNJ Dental School Newark, New Jersey, United States, 07101 Less <<
NCT01706874 - Completed - France ... More >> Hôpital Rotschild - Service d'Odontologie Paris, France, 75571 Less <<
NCT02360995 Dental Plaque ... More >> Gingivitis Less << Phase 4 Completed - United States, California ... More >> Loma Linda University Loma Linda, California, United States, 92350 Less <<
NCT00998907 Wound Infection ... More >> Incisional Hernia Less << Not Applicable Completed - Germany ... More >> Department of General, Visceral, Vascular and Pediatric Surgery, University of Saarland, Homburg/Saar, Germany, D-66421 Less <<
NCT02360995 - Completed - -
NCT00946049 Bacterial Colonization Not Applicable Completed - Germany ... More >> Albert-Ludwigs-University Freiburg, Department for Oral and Maxillofacial Surgery Freiburg, Germany, 79106 Less <<
NCT02533492 Wound Infection Phase 4 Completed - Taiwan ... More >> Chang Gung Memorial Hospital Kweishan, Taoyuan, Taiwan, 333 Less <<
NCT03659344 Infection, Surgical Site Not Applicable Completed - -
NCT02193165 Dental Plaque ... More >> Gingivitis Less << Phase 3 Completed - Puerto Rico ... More >> Centro Comercial Plaza Trujillo Trujillo Alto, Puerto Rico, 00976 Less <<
NCT02863874 Skin Structures and Soft Tissu... More >>e Infections Wound Infection Less << Not Applicable Recruiting December 2018 Sweden ... More >> Department of Gynecology and Obstetrics Recruiting Lund, Skåne, Sweden, 22185 Contact: Nana Wiberg, MD, PhD    +46704937350    nana.wiberg@med.lu.se    Contact: Kristine Sønnichsen, Med student    +4553601816    kristine008@gmail.com Less <<
NCT00761930 - Completed - -
NCT01014143 Dental Plaque Phase 2 Completed - United States, New Jersey ... More >> New Institutional Service Company Northfield, New Jersey, United States, 08225 Less <<
NCT01014143 - Completed - -
NCT02193165 - Completed - -
NCT01024738 Dental Plaque Phase 3 Completed - United States, New Jersey ... More >> TKL Research, Inc. Paramus, New Jersey, United States, 07652 Less <<
NCT00761930 Gingival Diseases Phase 3 Completed - United States, New York ... More >> Eastman Dental Center - University of Rochester Rochester, New York, United States, 14642-8315 Less <<
NCT01024738 - Completed - -
NCT00762177 - Completed - -
NCT00759187 Gingival Diseases Phase 3 Completed - United States, Massachusetts ... More >> Boston University School of Dental Medicine Boston, Massachusetts, United States, 02118 Less <<
NCT00762177 Oral Bacteria Phase 3 Completed - United States, New York ... More >> Department of Oral Biology Newark, New York, United States, 07103-2714 Less <<
NCT03700749 Abdominal Surgery ... More >> Surgical Site Infection Less << Phase 3 Not yet recruiting July 31, 2021 -
NCT00758563 Dental Plaque Phase 3 Completed - United States, Pennsylvania ... More >> Northampton Community College Bethlehem, Pennsylvania, United States, 18020 Less <<
NCT00759187 - Completed - -
NCT00758563 - Completed - -
NCT00926029 - Completed - -
NCT00926029 Dental Plaque Phase 3 Completed - United States, New Jersey ... More >> Concordia Clinical Research Cedar Knolls, New Jersey, United States, 07927 Less <<
NCT00768222 Breast Cancer Phase 4 Completed - China ... More >> Capital Medical Univ. affiliated Hospital Beijing, China Jilin Univ. affiliated Second Hospital Changchun, China Dalian Medical Univ. affiliated first Hospital Dalian, China First Affiliated Hospital, Sun Yat-sen Univ. Guangzhou, China Fudan Univ. affiliated Zhongshan Hospital Shanghai, China Shanghai Jiao Tong Univ. affiliated Ruijin Hospital Shanghai, China Less <<
NCT00762515 Dental Plaque Phase 3 Completed - United States, Kentucky ... More >> University of Louisville, School of Dentistry Louisville, Kentucky, United States, 40292 Less <<
NCT00763048 Gingival Diseases Phase 3 Completed - United States, Massachusetts ... More >> Forsyth Institute Boston, Massachusetts, United States, 02115 Less <<
NCT00759031 Dental Plaque Phase 3 Completed - United States, New York ... More >> Boston University School of Dental Medicine New York, New York, United States, 10016 Less <<
NCT00758290 Gingival Diseases Phase 3 Completed - United States, New York ... More >> Bluestone Center for Clinical Research, NYU College of Dentistry New York, New York, United States, 10016 Less <<
NCT00763048 - Completed - -
NCT00768222 - Completed - -
NCT00759031 - Completed - -
NCT00758290 - Completed - -
NCT00762515 - Completed - -
NCT00941668 Gingivitis Phase 4 Completed - United States, North Carolina ... More >> University of North Carolina Chapel Hill, North Carolina, United States, 27599 Less <<
NCT00941668 - Completed - -
NCT01072201 Mucositis Phase 3 Completed - Italy ... More >> Ariminum Research & Dental Education Center Rimini, Italy Less <<
NCT00762619 Gingival Diseases Phase 3 Completed - United States, New York ... More >> State University of New York at Buffalo Buffalo, New York, United States, 14260-1604 Israel The Hebrew University-Hadassah Jerusalem, Israel Less <<
NCT01072201 - Completed - -
NCT00762619 - Completed - -
NCT00926328 Gingivitis Phase 3 Completed - Spain ... More >> Dr. Fernando Autran Barcelona, Spain Less <<
NCT01220700 Wound Infections Not Applicable Completed - Finland ... More >> Oulu University Hospital/ Paediatric Surgery Oulu, Finland, 90230 Less <<
NCT00926328 - Completed - -
NCT00763165 Periodontal Diseases Phase 3 Unknown December 2009 Australia ... More >> Discipline of Medicine Chermside, Australia Less <<
NCT00758394 Dental Plaque Phase 3 Completed - United States, New York ... More >> Bluestone Center for Clinical Research, NYU College of Dentistry New York, New York, United States, 10016 Less <<
NCT00763269 - Completed - -
NCT00763269 Dentin Hypersensitivity Phase 3 Completed - United States, New Jersey ... More >> Concordia Clinical Research Cedar Knolls, New Jersey, United States, 08225 Less <<
NCT00762762 Periodontitis Phase 3 Completed - Australia ... More >> Republic of Marshall Islands Queensland, Australia Less <<
NCT02243046 - Completed - -
NCT00758394 - Completed - -
NCT00762762 - Completed - -
NCT00763256 - Completed - -
NCT00762528 Gingivitis Phase 4 Completed - United States, North Carolina ... More >> East Carolina University, Brody School of Medicine Greenville, North Carolina, United States, 27834 Less <<
NCT02243046 Dental Plaque and Gingivitis Phase 2 Completed - Dominican Republic ... More >> Spa Dental Santo Domingo, Dominican Republic Less <<
NCT00932503 Wound Infection Not Applicable Completed - Germany ... More >> Department of General, Visceral, Vascular and Pediatric Surgery, University of Saarland, D-66421 Homburg/Saar, Germany Homburg/Saar, Germany, D-66421 Less <<
NCT00763256 Periodontal Disease Phase 3 Completed - Australia ... More >> Logan Hospital Oral Health Clinic Queensland, Australia Less <<
NCT00762450 - Completed - -
NCT00762450 Dental Plaque Phase 3 Completed - Switzerland ... More >> University of Zurich, Dental Institute Dept. of Preventive Zurich, Switzerland Less <<
NCT00762528 - Completed - -
NCT00981825 Salivary Bacteria Levels Phase 3 Completed - India ... More >> India GTC, Colgate Palmolive(I) ltd Mumbai, India Less <<
NCT02366689 Dental Plaque ... More >> Gingivitis Less << Phase 4 Completed - United States, New Jersey ... More >> Concordia Clinical Research Cedar Knolls, New Jersey, United States, 07927 Less <<
NCT02366689 - Completed - -
NCT02194621 Oral Bacteria Levels in the Mo... More >>uth Less << Phase 4 Completed - United States, New Jersey ... More >> Rutgers School of Dental Medicine Newark, New Jersey, United States, 07107 Less <<
NCT02194621 - Completed - -
NCT00981825 - Completed - -
NCT00966953 - Completed - -
NCT03081962 Surgical Site Infection Phase 3 Recruiting August 2017 Spain ... More >> General Hospital Elche Recruiting Elche, Alicante, Spain, 03203 Contact: Jaime Ruiz-Tovar    (0034)630534808    jruiztovar@gmail.com Less <<
NCT01881074 - Completed - United States, Florida ... More >> University of Florida Gainesville, Florida, United States, 32610 Less <<
NCT02670135 Periodontal Disease ... More >> Systemic Inflammatory Markers Less << Phase 4 Unknown June 2016 -
NCT00966953 Gingival Diseases Phase 3 Completed - United States, New York ... More >> Eastman Dental Center - University of Rochester Rochester, New York, United States, 14642-8315 Less <<
NCT03386240 Surgical Site Infection ... More >> Surgical Wound Infection Cesarean Section; Infection Cesarean Section Complications Less << Not Applicable Recruiting January 2021 United States, Texas ... More >> University of Texas Medical Branch in Galveston Recruiting Galveston, Texas, United States, 77550 Contact: Violetta Lozovyy, M.D.    409-772-1571    vilozovy@utmb.edu    Contact: Antonio Saad, M.D.    (409)772-0982    afsaad@utmb.edu Less <<
NCT00250406 Renal Calculi ... More >> Ureteral Obstruction Less << Phase 2 Completed - Canada, Ontario ... More >> Urology, St. Joseph's Hospital London, Ontario, Canada, N6A 4V2 Less <<
NCT01799226 - Completed - -
NCT01457859 Complication of Coronary Arter... More >>y Bypass Graft Surgical Wound Infection Less << Phase 4 Unknown October 2013 Israel ... More >> Rambam Health Care Campus, Depatment of cardiac surgery Not yet recruiting Haifa, Israel, 31096 Contact: Liran Shani, MD       l_shani@rambam.health.gov.il    Principal Investigator: Liran Shani, MD Less <<
NCT01442701 - Active, not recruiting August 1, 2019 United States, California ... More >> Stanford University Stanford, California, United States, 94305 Less <<
NCT01019447 Surgical Site Infection Phase 4 Completed - Egypt ... More >> Al-Zeraaein Hospital Cairo, Egypt Cairo University Kasr Al-Aini Hospital Cairo, Egypt Less <<
NCT01799226 Gingivitis Not Applicable Completed - United States, Michigan ... More >> Michigan Center for Oral Health Research Ann Arbor, Michigan, United States, 48106 Less <<
NCT02847936 Episiotomy Phase 4 Unknown September 2016 Tunisia ... More >> University Hospital Bougatfa Recruiting Bizerte, Tunisia, 7000 Contact: AMIRA AYACHI, Ph D    53660148 ext 00216    benmrad.amira@yahoo.fr Less <<
NCT01292343 Dry Socket Wo... More >>und Infection Less << Not Applicable Completed - United States, New York ... More >> University of Rochester Eastman Dental Center Rochester, New York, United States, 14620 Less <<
NCT00762853 - Completed - -
NCT03191721 Peri-Implantitis ... More >> Periodontal Diseases Less << Phase 3 Completed - Brazil ... More >> State University of Maringa Maringa, Santa Catarina, Brazil, 87020-900 Guarulhos University Guarulhos, São Paulo, Brazil, 07023-070 Less <<
NCT00762853 Dental Plaque Phase 3 Completed - Thailand ... More >> Mahidol University Bangkok, Bangkok 10110, Thailand Less <<
NCT01762904 Infectious Diseases Phase 3 Completed - Mexico ... More >> University of Guanajuato Leon, Guanajuato, Mexico, 37000 Less <<
NCT01212315 Postoperative Wound Infection Phase 4 Completed - Sweden ... More >> Dep of Cardiovascular Surgery and Anesthesia, Sahlgrenska Univerity Hospital Gothenburg, Sweden, 413 45 Less <<
NCT01762904 - Completed - -
NCT01620294 Infection Phase 3 Completed - Hungary ... More >> Department of Surgery Medical Faculty, University of Pecs, Hungary Pecs, Hungary, 7624 Less <<
NCT02192060 Dental Plaque Not Applicable Completed - Brazil ... More >> Dentistry Faculty, Federal University of Rio Grande do Sul Porto Alegre, Rio Grande do Sul, Brazil, 90035-003 Less <<
NCT03642353 Generalized Aggressive Periodo... More >>ntitis Less << Phase 4 Completed - Brazil ... More >> University of Campinas, UNICAMP Piracicaba, Sao Paulo, Brazil, 13414-903 Less <<
NCT01123616 Wound Infection Phase 2 Unknown June 2010 Hungary ... More >> Department of Surgery Medical Faculty, University of Pecs, Hungary Pecs, Hungary Less <<
NCT03763279 Surgical Site Infection Phase 3 Not yet recruiting March 31, 2019 -
NCT02018289 Surgical Site Infection Phase 3 Completed - Spain ... More >> General University Hospital Elche Elche, Alicante, Spain, 03203 Less <<
NCT03241407 Dental Implants ... More >> Cigarette Smoking Less << Not Applicable Completed - Brazil ... More >> School of Dentistry - Paulista University UNIP São Paulo, SP, Brazil, 052 Less <<
NCT03246776 Chronic Hand Eczema Phase 4 Completed - China, Beijing ... More >> Friendship Hospital Beijing, Beijing, China, 100000 Less <<
NCT01101789 Surgical Wound Infection Not Applicable Completed - Finland ... More >> North Carelia central hospital Joensuu, Finland, 80210 Less <<
NCT01509976 Triclosan Effects on Microbial... More >> Flora. Less << Not Applicable Unknown December 2012 United States, California ... More >> Stanford University Recruiting Stanford, California, United States, 94305 Contact: Gina A Suh, MD    650-724-8434    gsuh@stanford.edu    Contact: Jade Riotto    650-724-8434    jriotto@stanford.edu    Principal Investigator: Julie Parsonnet, MD          Sub-Investigator: Gina A Suh, MD Less <<
NCT01869257 Colorectal Resection Phase 3 Completed - Italy ... More >> San Gerardo Hospital Monza, Italy, 20900 Less <<
NCT03145610 Biological Markers; Dental Imp... More >>lants; Cytokines; Triclosan; Toothpastes; Peri-Implantitis; Microbiology Less << Not Applicable Completed - -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.45mL

0.69mL

0.35mL

17.27mL

3.45mL

1.73mL

34.54mL

6.91mL

3.45mL

References

 

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