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Quality Control of 2-Methylpyrazine Purity: 98% SDS Specification

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Product Details of 2-Methylpyrazine

CAS No. :	109-08-0
Formula :	C₅H₆N₂
M.W :	94.11
SMILES Code :	CC1=CN=CC=N1
MDL No. :	MFCD00006142
InChI Key :	CAWHJQAVHZEVTJ-UHFFFAOYSA-N
Pubchem ID :	7976

Safety of 2-Methylpyrazine

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H225-H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338
Class:	3
UN#:	1993
Packing Group:	Ⅲ

Application In Synthesis of 2-Methylpyrazine

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 109-08-0 ]

[ 109-08-0 ] Synthesis Path-Downstream 1~37

1
[ 110-85-0 ]
[ 290-37-9 ]
[ 109-08-0 ]
[ 13925-00-3 ]
[ 109-97-7 ]

References: [1]Chemistry of Heterocyclic Compounds,1993,vol. 29,p. 1308 - 1315.
    Khimiya Geterotsiklicheskikh Soedinenii,1993,p. 1516 - 1525.
[2]Bulletin of the Academy of Sciences of the USSR Division of Chemical Science,1990,vol. 39,p. 1340 - 1345.
    Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya,1990,p. 1483 - 1488.
[3]Chemistry of Heterocyclic Compounds,1993,vol. 29,p. 1308 - 1315.
    Khimiya Geterotsiklicheskikh Soedinenii,1993,p. 1516 - 1525.

2
[ 110-85-0 ]
[ 288-32-4 ]
[ 290-37-9 ]
[ 616-47-7 ]
[ 109-08-0 ]
[ 13925-00-3 ]
[ 693-98-1 ]

References: [1]Bulletin of the Academy of Sciences of the USSR Division of Chemical Science,1990,vol. 39,p. 1340 - 1345.
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya,1990,p. 1483 - 1488.

3
[ 123-84-2 ]
[ 109-08-0 ]
[ 13925-00-3 ]

References: [1]Chemistry of Heterocyclic Compounds,1993,vol. 29,p. 1308 - 1315.
Khimiya Geterotsiklicheskikh Soedinenii,1993,p. 1516 - 1525.

4
[ 123-84-2 ]
[ 290-37-9 ]
[ 109-08-0 ]
[ 123-32-0 ]
[ 13925-00-3 ]
[ 693-98-1 ]
[ 15707-23-0 ]

References: [1]Chemistry of Heterocyclic Compounds,1993,vol. 29,p. 1308 - 1315.
Khimiya Geterotsiklicheskikh Soedinenii,1993,p. 1516 - 1525.

5
[ 107-15-3 ]
[ 290-37-9 ]
[ 109-08-0 ]
[ 13925-00-3 ]

References: [1]Chemistry of Heterocyclic Compounds,1993,vol. 29,p. 1308 - 1315.
Khimiya Geterotsiklicheskikh Soedinenii,1993,p. 1516 - 1525.
[2]Chemistry of Heterocyclic Compounds,1993,vol. 29,p. 1308 - 1315.
Khimiya Geterotsiklicheskikh Soedinenii,1993,p. 1516 - 1525.

6
[ 56-45-1 ]
[ 290-37-9 ]
[ 109-08-0 ]
[ 13925-00-3 ]
[ 13925-03-6 ]

References: [1]Journal of Agricultural and Food Chemistry,1999,vol. 47,p. 4332 - 4335.

7
[ 109-08-0 ]
[ 6609-56-9 ]
[ 496863-95-7 ]

Yield	Reaction Conditions	Operation in experiment
39%		2-Methoxybenzonitrile (3.0 g, 22.5 mmol) and 2-methylpyrazine (2.2 g, 23.0 mmol) were dissolved in an ice-water bathIn dry tetrahydrofuran (50 mL) and stirred under nitrogen for 1.5 hours.under this conditionLithium diisopropylamide (23 mL, 45.06 mmol, tetrahydrofuran solution) was slowly added, and the addition was complete and the temperature was raised to 40C and stirring was continued for 3 hours.The reaction solution was cooled to ambient temperature, quenched with ammonium chloride solution, extracted with ethyl acetate (50 mL × 3), dried over anhydrous sodium sulfate, and filtered.The organic layer was concentrated under reduced pressure and the residue was purified by flash column chromatography (petroleum ether/ethyl acetate = 1/1) to give compound 5.1 as a yellow solid.Body (2.2 g, yield: 39%).

References: [1]Patent: CN107674029,2018,A .Location in patent: Paragraph 0228; 0229; 0230; 0230; 0231; 0232.
[2]Journal of Medicinal Chemistry,2003,vol. 46,p. 222 - 236.

8
[ 109-08-0 ]
[ 5780-66-5 ]

References: [1]Heterocycles,2003,vol. 60,p. 953 - 957.

9
[ 109-08-0 ]
[ 117810-52-3 ]

References: [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 71 - 85.
[2]Bioorganic and Medicinal Chemistry Letters,1998,vol. 8,p. 3469 - 3474.
[3]Patent: WO2015/38417,2015,A1 .

10
[ 109-08-0 ]
[ 25594-37-0 ]
[ 31396-35-7 ]
[ 98-97-5 ]
[ 5780-66-5 ]
[ 874-54-4 ]
[ 32046-09-6 ]

References: [1]Chemistry - A European Journal,2008,vol. 14,p. 2340 - 2348.
[2]Chemistry - A European Journal,2008,vol. 14,p. 2340 - 2348.

11
[ 134276-45-2 ]
[ 78-98-8 ]
[ 109-08-0 ]
[ 123-32-0 ]
[ 5910-89-4 ]
[ 13360-65-1 ]
[ 108-50-9 ]
[ 55138-74-4 ]
[ 14667-55-1 ]
[ 80935-98-4 ]
[ 13925-07-0 ]
[ 15707-34-3 ]