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[ CAS No. 288-42-6 ]

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type HazMat fee
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Inaccessible (Haz class 6.1), Domestic USD 41.00
Inaccessible (Haz class 6.1), International USD 64.00
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Chemical Structure| 288-42-6
Chemical Structure| 288-42-6
Structure of 288-42-6 * Storage: {[proInfo.prStorage]}

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Product Details of [ 288-42-6 ]

CAS No. :288-42-6 MDL No. :MFCD00009751
Formula : C3H3NO Boiling Point : 69.5°C at 760 mmHg
Linear Structure Formula :- InChI Key :N/A
M.W :69.06 g/mol Pubchem ID :9255
Synonyms :

Safety of [ 288-42-6 ]

Signal Word:Danger Class:3,8
Precautionary Statements:P210-P233-P280-P370+P378-P303+P361+P353-P305+P351+P338+P310 UN#:2924
Hazard Statements:H225-H318 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 288-42-6 ]

  • Upstream synthesis route of [ 288-42-6 ]
  • Downstream synthetic route of [ 288-42-6 ]

[ 288-42-6 ] Synthesis Path-Upstream   1~5

  • 1
  • [ 288-42-6 ]
  • [ 124-38-9 ]
  • [ 74-88-4 ]
  • [ 31698-88-1 ]
Reference: [1] Journal of the American Chemical Society, 2010, vol. 132, # 26, p. 8858 - 8859
  • 2
  • [ 288-42-6 ]
  • [ 68-12-2 ]
  • [ 65373-52-6 ]
YieldReaction ConditionsOperation in experiment
80%
Stage #1: With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1 h;
Stage #2: at 20℃;
At -78 °C, a solution of F-1 (800mg, 11.58mmol) in THF was treated with 1.6 M solution of n-BuLi in hexanes (7.2 mL, 11.58 mmol). The reaction was stirred for 1 hour, and then a solution of DMF (0.89 mmol, 1 1.58mmol) in THF (8 mL) was added. The reaction was warmed to room temperature and stirred overnight. The reaction mixture was treated with MeOH, filtered through Dowex 50W x 8-200 resin (H+ form, 1 : 1 ratio to oxazole F-1), and washed with MeOH. The combined filtrate was concentrated to obtain the crude aldehyde F-2a, F-ia . This material was then purified by column chromatography (100-200 mesh silica gel, 2percent Et20/CH2C12) to obtain the purified aldehyde (900mg, 80percent) as a light brown liquid (Rf = 0.7(2percent Et20/CH2C12)). This product was used in the next step without any characterization.
Reference: [1] Patent: WO2011/35009, 2011, A1, . Location in patent: Page/Page column 45-46
[2] Patent: WO2008/61109, 2008, A2, . Location in patent: Page/Page column 62
[3] Patent: WO2005/102998, 2005, A1, . Location in patent: Page/Page column 31
[4] Journal of Photochemistry and Photobiology A: Chemistry, 2016, vol. 316, p. 95 - 103
  • 3
  • [ 288-42-6 ]
  • [ 4394-85-8 ]
  • [ 65373-52-6 ]
Reference: [1] Patent: EP1731513, 2006, A1, . Location in patent: Page/Page column 18
[2] Patent: WO2007/37010, 2007, A1, . Location in patent: Page/Page column 32-34
  • 4
  • [ 288-42-6 ]
  • [ 68-12-2 ]
  • [ 130551-92-7 ]
Reference: [1] Patent: US2009/170907, 2009, A1, . Location in patent: Page/Page column 46
  • 5
  • [ 288-42-6 ]
  • [ 78191-00-1 ]
  • [ 77311-07-0 ]
Reference: [1] Patent: WO2009/77990, 2009, A1, . Location in patent: Page/Page column 94
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