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[ CAS No. 104-53-0 ] {[proInfo.proName]}

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Chemical Structure| 104-53-0
Chemical Structure| 104-53-0
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Product Citations

Anushree Mondal ; Pronay Roy ; Jaclyn Carrannatto , et al. DOI: PubMed ID:

Abstract: The prenylated-flavin mononucleotide-dependent decarboxylases (also known as UbiD-like enzymes) are the most recently discovered family of decarboxylases. The modified flavin facilitates the decarboxylation of unsaturated carboxylic acids through a novel mechanism involving 1,3-dipolar cyclo-addition chemistry. UbiD-like enzymes have attracted considerable interest for biocatalysis applications due to their ability to catalyse (de)carboxylation reactions on a broad range of aromatic substrates at otherwise unreactive carbon centres. There are now ∼35[thin space (1/6-em)]000 protein sequences annotated as hypothetical UbiD-like enzymes. Sequence similarity network analyses of the UbiD protein family suggests that there are likely dozens of distinct decarboxylase enzymes represented within this family. Furthermore, many of the enzymes so far characterized can decarboxylate a broad range of substrates. Here we describe a strategy to identify potential substrates of UbiD-like enzymes based on detecting enzyme-catalysed solvent deuterium exchange into potential substrates. Using ferulic acid decarboxylase (FDC) as a model system, we tested a diverse range of aromatic and heterocyclic molecules for their ability to undergo enzyme-catalysed H/D exchange in deuterated buffer. We found that FDC catalyses H/D exchange, albeit at generally very low levels, into a wide range of small, aromatic molecules that have little resemblance to its physiological substrate. In contrast, the sub-set of aromatic carboxylic acids that are substrates for FDC-catalysed decarboxylation is much smaller. We discuss the implications of these findings for screening uncharacterized UbiD-like enzymes for novel (de)carboxylase activity.

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Product Details of [ 104-53-0 ]

CAS No. :104-53-0 MDL No. :MFCD00007021
Formula : C9H10O Boiling Point : -
Linear Structure Formula :- InChI Key :YGCZTXZTJXYWCO-UHFFFAOYSA-N
M.W : 134.18 Pubchem ID :7707
Synonyms :

Calculated chemistry of [ 104-53-0 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 10
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.22
Num. rotatable bonds : 3
Num. H-bond acceptors : 1.0
Num. H-bond donors : 0.0
Molar Refractivity : 41.22
TPSA : 17.07 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.2 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.68
Log Po/w (XLOGP3) : 1.3
Log Po/w (WLOGP) : 1.82
Log Po/w (MLOGP) : 2.1
Log Po/w (SILICOS-IT) : 2.66
Consensus Log Po/w : 1.91

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 2.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -1.74
Solubility : 2.46 mg/ml ; 0.0183 mol/l
Class : Very soluble
Log S (Ali) : -1.26
Solubility : 7.4 mg/ml ; 0.0551 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -3.12
Solubility : 0.101 mg/ml ; 0.000755 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.0

Safety of [ 104-53-0 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 104-53-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 104-53-0 ]
  • Downstream synthetic route of [ 104-53-0 ]

[ 104-53-0 ] Synthesis Path-Upstream   1~18

  • 1
  • [ 104-53-0 ]
  • [ 587-63-3 ]
Reference: [1] Organic Letters, 2008, vol. 10, # 6, p. 1311 - 1314
  • 2
  • [ 104-53-0 ]
  • [ 90857-62-8 ]
  • [ 587-63-3 ]
Reference: [1] Chemistry - A European Journal, 2004, vol. 10, # 23, p. 5964 - 5970
  • 3
  • [ 104-53-0 ]
  • [ 587-63-3 ]
Reference: [1] Russian Journal of Organic Chemistry, 2013, vol. 49, # 5, p. 712 - 716[2] Zh. Org. Khim., 2013, vol. 49, # 5, p. 729 - 733,5
  • 4
  • [ 104-53-0 ]
  • [ 645-45-4 ]
Reference: [1] Organic Letters, 2015, vol. 17, # 15, p. 3666 - 3669
[2] New Journal of Chemistry, 2017, vol. 41, # 3, p. 931 - 939
[3] Tetrahedron Letters, 2017, vol. 58, # 26, p. 2533 - 2536
  • 5
  • [ 122-97-4 ]
  • [ 104-53-0 ]
  • [ 1124-14-7 ]
  • [ 60045-27-4 ]
  • [ 83-33-0 ]
  • [ 501-52-0 ]
YieldReaction ConditionsOperation in experiment
43 %Chromat. With sodium bromate; sulfuric acid; sodium bromide In water at 20℃; for 24 h; General procedure: A total of 1.0 g of 1-octanol (7.69 mmol) was taken in a 50-mL round-bottomed flask, to it NaBr 0.523 g (0.66 eq.), NaBrO 3 0.383 g (0.33 eq.), and 10 mL of H 2 O [comprises the bromide and bromate in 2:1 molar ratio] were added[6f]. The reaction mixture was stirred vigorously to dissolve the contents completely. To the above reaction mixture, the aqueous H 2 SO 4 solution (0.5 eq.) was added slowly under stirring over a period of 2.5 h at room temperature (prepared by adding 0.21 mL of 98percent H 2 SO 4 to 1 mL of water). The reaction mixture was allowed to stir for up to 24 h. After the completion of reaction, the product was extracted with CH 2 Cl 2 (3 15 mL), the organic layer was dried with Na 2 SO 4 and removal of the solvent obtained octyloctanoate in 98percent yield (0.953 g) as colorless liquid. The product was confirmed by GC–MS as well as by NMR.
Reference: [1] Synthetic Communications, 2018, vol. 48, # 13, p. 1663 - 1670
  • 6
  • [ 104-55-2 ]
  • [ 104-53-0 ]
  • [ 122-97-4 ]
  • [ 104-65-4 ]
  • [ 33795-14-1 ]
  • [ 103-41-3 ]
  • [ 621-82-9 ]
  • [ 54518-01-3 ]
Reference: [1] Journal of Chemistry, 2018, vol. 2018,
  • 7
  • [ 104-55-2 ]
  • [ 104-53-0 ]
  • [ 122-97-4 ]
  • [ 104-65-4 ]
  • [ 104-54-1 ]
  • [ 33795-14-1 ]
  • [ 103-41-3 ]
  • [ 621-82-9 ]
  • [ 54518-01-3 ]
Reference: [1] Journal of Chemistry, 2018, vol. 2018,
  • 8
  • [ 104-55-2 ]
  • [ 67-63-0 ]
  • [ 104-53-0 ]
  • [ 104-65-4 ]
  • [ 104-54-1 ]
  • [ 33795-14-1 ]
  • [ 103-41-3 ]
  • [ 621-82-9 ]
  • [ 54518-01-3 ]
Reference: [1] ChemCatChem, 2014, vol. 6, # 11, p. 3246 - 3253
  • 9
  • [ 104-55-2 ]
  • [ 67-63-0 ]
  • [ 104-53-0 ]
  • [ 122-97-4 ]
  • [ 104-65-4 ]
  • [ 104-54-1 ]
  • [ 33795-14-1 ]
  • [ 103-41-3 ]
  • [ 621-82-9 ]
  • [ 54518-01-3 ]
Reference: [1] ChemCatChem, 2014, vol. 6, # 11, p. 3246 - 3253
  • 10
  • [ 104-53-0 ]
  • [ 928-49-4 ]
  • [ 29898-25-7 ]
Reference: [1] Journal of the American Chemical Society, 2003, vol. 125, # 21, p. 6372 - 6373
  • 11
  • [ 104-53-0 ]
  • [ 558-37-2 ]
  • [ 928-49-4 ]
  • [ 29898-25-7 ]
  • [ 5054-71-7 ]
Reference: [1] Synlett, 2009, # 18, p. 2939 - 2942
  • 12
  • [ 64-17-5 ]
  • [ 104-55-2 ]
  • [ 104-53-0 ]
  • [ 122-97-4 ]
  • [ 104-54-1 ]
  • [ 7148-78-9 ]
Reference: [1] Dalton Transactions, 2008, # 19, p. 2542 - 2548
  • 13
  • [ 64-17-5 ]
  • [ 104-55-2 ]
  • [ 104-53-0 ]
  • [ 1476-07-9 ]
  • [ 7148-78-9 ]
Reference: [1] Organic Process Research and Development, 2017, vol. 21, # 9, p. 1311 - 1319
  • 14
  • [ 211675-73-9 ]
  • [ 104-53-0 ]
  • [ 701-34-8 ]
  • [ 213264-51-8 ]
Reference: [1] Tetrahedron, 2001, vol. 57, # 35, p. 7481 - 7486
  • 15
  • [ 104-53-0 ]
  • [ 1227382-48-0 ]
  • [ 127180-75-0 ]
Reference: [1] Journal of Organic Chemistry, 2016, vol. 81, # 3, p. 1251 - 1255
[2] Journal of Organic Chemistry, 2016, vol. 81, # 3, p. 1251 - 1255
  • 16
  • [ 104-53-0 ]
  • [ 127180-75-0 ]
Reference: [1] Angewandte Chemie - International Edition, 2018, vol. 57, # 36, p. 11683 - 11687[2] Angew. Chem., 2018, vol. 130, # 36, p. 11857 - 11861,5
  • 17
  • [ 104-53-0 ]
  • [ 141403-49-8 ]
Reference: [1] Tetrahedron, 2007, vol. 63, # 39, p. 9758 - 9763
  • 18
  • [ 104-53-0 ]
  • [ 203854-62-0 ]
Reference: [1] Angewandte Chemie - International Edition, 2018, vol. 57, # 42, p. 13829 - 13832[2] Angew. Chem., 2018, vol. 130, # 42, p. 14025 - 14028,4
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