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2-Naphthalenemethanol
Chemistry
Organic Building Blocks
Aryls

[ CAS No. 1592-38-7 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 1592-38-7
Chemical Structure| 1592-38-7
Structure of 1592-38-7 * Storage: {[proInfo.prStorage]}

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Quality Control of [ 1592-38-7 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification
Alternatived Products of [ 1592-38-7 ]
Product Citations

Product Citations

Anushree Mondal ; Pronay Roy ; Jaclyn Carrannatto , et al. DOI: PubMed ID:

Abstract: The prenylated-flavin mononucleotide-dependent decarboxylases (also known as UbiD-like enzymes) are the most recently discovered family of decarboxylases. The modified flavin facilitates the decarboxylation of unsaturated carboxylic acids through a novel mechanism involving 1,3-dipolar cyclo-addition chemistry. UbiD-like enzymes have attracted considerable interest for biocatalysis applications due to their ability to catalyse (de)carboxylation reactions on a broad range of aromatic substrates at otherwise unreactive carbon centres. There are now ∼35[thin space (1/6-em)]000 protein sequences annotated as hypothetical UbiD-like enzymes. Sequence similarity network analyses of the UbiD protein family suggests that there are likely dozens of distinct decarboxylase enzymes represented within this family. Furthermore, many of the enzymes so far characterized can decarboxylate a broad range of substrates. Here we describe a strategy to identify potential substrates of UbiD-like enzymes based on detecting enzyme-catalysed solvent deuterium exchange into potential substrates. Using ferulic acid decarboxylase (FDC) as a model system, we tested a diverse range of aromatic and heterocyclic molecules for their ability to undergo enzyme-catalysed H/D exchange in deuterated buffer. We found that FDC catalyses H/D exchange, albeit at generally very low levels, into a wide range of small, aromatic molecules that have little resemblance to its physiological substrate. In contrast, the sub-set of aromatic carboxylic acids that are substrates for FDC-catalysed decarboxylation is much smaller. We discuss the implications of these findings for screening uncharacterized UbiD-like enzymes for novel (de)carboxylase activity.

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Product Details of [ 1592-38-7 ]

CAS No. :1592-38-7 MDL No. :MFCD00004124
Formula : C11H10O Boiling Point : -
Linear Structure Formula :(C10H7)CH2OH InChI Key :MFGWMAAZYZSWMY-UHFFFAOYSA-N
M.W : 158.20 Pubchem ID :74128
Synonyms :

Calculated chemistry of [ 1592-38-7 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 12
Num. arom. heavy atoms : 10
Fraction Csp3 : 0.09
Num. rotatable bonds : 1
Num. H-bond acceptors : 1.0
Num. H-bond donors : 1.0
Molar Refractivity : 50.08
TPSA : 20.23 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -5.7 cm/s

Lipophilicity

Log Po/w (iLOGP) : 2.08
Log Po/w (XLOGP3) : 2.21
Log Po/w (WLOGP) : 2.18
Log Po/w (MLOGP) : 2.56
Log Po/w (SILICOS-IT) : 2.85
Consensus Log Po/w : 2.38

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 2.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -2.76
Solubility : 0.273 mg/ml ; 0.00172 mol/l
Class : Soluble
Log S (Ali) : -2.27
Solubility : 0.851 mg/ml ; 0.00538 mol/l
Class : Soluble
Log S (SILICOS-IT) : -3.89
Solubility : 0.0204 mg/ml ; 0.000129 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.0

Safety of [ 1592-38-7 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1592-38-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1592-38-7 ]

[ 1592-38-7 ] Synthesis Path-Downstream   1~6

  • 1
  • [ 532-02-5 ]
  • [ 1592-38-7 ]
Reference： [1]Helvetica Chimica Acta,1923,vol. 6,p. 882
  • 2
  • [ 130723-13-6 ]
  • (2RS,4SR)-4-hydroxy-2-methyl-4-[3-(naphth-2-ylmethoxy)-5-trifluoromethylphenyl]tetrahydropyran [ No CAS ]
  • [ 1592-38-7 ]
  • 3-(naphth-2-ylmethoxy)-5-trifluoromethylbromobenzene [ No CAS ]
YieldReaction ConditionsOperation in experiment
80% The (2RS,4SR)-4-hydroxy-2-methyl-4-[3-(naphth-2-ylmethoxy)-5-trifluoromethylphenyl]tetrahydropyran used as a starting material was obtained as follows: Using the procedure described in the first paragraph of Note e. below Table IV in Example 15, 2-naphthalenemethanol was reacted with <strong>[130723-13-6]3-fluoro-5-trifluoromethylbromobenzene</strong> to give 3-(naphth-2-ylmethoxy)-5-trifluoromethylbromobenzene (80%), m.p. 68-70 C.
Reference： [1]Patent: US5098930,1992,A
  • 3
  • [ 5683-31-8 ]
  • [ 1592-38-7 ]
  • [ 1234580-88-1 ]
Reference： [1]Journal of the American Chemical Society,2010,vol. 132,p. 9280 - 9282
  • 4
  • [ 1592-38-7 ]
  • [ 2243-82-5 ]
Reference： [1]Catalysis science and technology,2013,vol. 3,p. 318 - 327
[2]Green Chemistry,2013,vol. 15,p. 1956 - 1961
[3]Angewandte Chemie - International Edition,2012,vol. 51,p. 544 - 547
  • 5
  • [ 1592-38-7 ]
  • [ 56844-12-3 ]
  • 6-bromo-4-(naphthalen-2-ylmethoxy)thieno[2,3-d]pyrimidine [ No CAS ]
YieldReaction ConditionsOperation in experiment
86% With caesium carbonate; In acetonitrile; for 6h;Inert atmosphere; Reflux; General procedure: 6-Bromo-4-chlorothieno[2,3-d]pyrimidine(5a) (200 mg, 0.802 mmol) was mixed with 1-phenylethanol (2a) (118 mg, 0.962 mmol), Cs2CO3( 313 mg, 0.962 mmol) and acetonitrile (2 mL). The reaction was then stirredunder nitrogen atmosphere at reflux and followed by GC. The mixture was cooledto rt, diluted with EtOAc (40 mL), washed with sat. aq. KHCO3 (20mL), water (2×20 mL) and brine (30 mL). The combined organic fractions weredried over Na2SO4 and concentrated in vacuum. Crudeproduct was absorbed onto Celite 545 and purified by silica gel columnchromatography (n-pentane/EtOAc,6/1). This gave 245 mg (0.730 mmol, 91%) of 6a as an off-white solid.
Reference： [1]Journal of Fluorine Chemistry,2013,vol. 153,p. 82 - 88
  • 6
  • [ 1592-38-7 ]
  • [ 256652-04-7 ]
Reference： [1]Journal of the American Chemical Society,2015,vol. 137,p. 1593 - 1600
[2]Journal of the American Chemical Society,2015,vol. 137,p. 1593 - 1600
[3]Journal of the American Chemical Society,2015,vol. 137,p. 1593 - 1600

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