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Chemical Structure| 99-94-5 Chemical Structure| 99-94-5
Chemical Structure| 99-94-5

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p-Toluic Acid is a benzoic acid derivative commonly used as an intermediate in chemical synthesis and drug research.

Synonyms: 4-Methylbenzoic acid

4.5 *For Research Use Only !

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Product Citations

Product Citations

Siriboe, Mary G ; Vargas, David A ; Fasan, Rudi ;

Abstract: Chiral cyclopropanols are highly desirable building blocks for medicinal chemistry, but the stereoselective synthesis of these molecules remains challenging. Here, a novel strategy is reported for the diastereo- and enantioselective synthesis of cyclopropanol derivatives via the biocatalytic asymmetric cyclopropanation of vinyl esters with ethyl diazoacetate (EDA). A dehaloperoxidase enzyme from Amphitrite ornata was repurposed to catalyze this challenging cyclopropanation reaction, and its activity and stereoselectivity were optimized via protein engineering. Using this system, a broad range of electron-deficient vinyl esters were efficiently converted to the desired cyclopropanation products with up to 99.5:0.5 diastereomeric and enantiomeric ratios. In addition, the engineered dehaloperoxidase-based biocatalyst is able to catalyze a variety of other abiological carbene transfer reactions, including N−H/S−H carbene insertion with EDA as well as cyclopropanation with diazoacetonitrile, thus adding to the multifunctionality of this enzyme and defining it as a valuable new scaffold for the development of novel carbene transferases.

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Product Details of p-Toluic acid

CAS No. :99-94-5
Formula : C8H8O2
M.W : 136.15
SMILES Code : O=C(O)C1=CC=C(C)C=C1
Synonyms :
4-Methylbenzoic acid
MDL No. :MFCD00002565
InChI Key :LPNBBFKOUUSUDB-UHFFFAOYSA-N
Pubchem ID :7470

Safety of p-Toluic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of p-Toluic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 99-94-5 ]
  • Downstream synthetic route of [ 99-94-5 ]

[ 99-94-5 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 82998-57-0 ]
  • [ 170230-88-3 ]
  • [ 99-94-5 ]
References: [1] Journal of Organic Chemistry, 2009, vol. 74, # 2, p. 795 - 809.
 

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