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Quality Control of H-Gly-OMe.HCl Purity: 98% SDS Specification

COA

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NMR

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Product Details of H-Gly-OMe.HCl

CAS No. :	5680-79-5
Formula :	C₃H₈ClNO₂
M.W :	125.55
SMILES Code :	NCC(OC)=O.[H]Cl
Synonyms :	Methyl 2-aminoacetate hydrochloride
MDL No. :	MFCD00012870
InChI Key :	COQRGFWWJBEXRC-UHFFFAOYSA-N
Pubchem ID :	122755

Safety of H-Gly-OMe.HCl

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of H-Gly-OMe.HCl

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 5680-79-5 ]
Downstream synthetic route of [ 5680-79-5 ]

[ 5680-79-5 ] Synthesis Path-Upstream 1~2

1
[ 123-91-1 ]
[ 24424-99-5 ]
[ 5680-79-5 ]
[ 42492-57-9 ]

References: [1] Patent: US5747535, 1998, A, .

2
[ 123-91-1 ]
[ 24424-99-5 ]
[ 5680-79-5 ]
[ 42492-57-9 ]

References: [1] Patent: EP739886, 1996, A2, .

[ 5680-79-5 ] Synthesis Path-Downstream 1~35

1
[ 5680-79-5 ]
[ 141871-02-5 ]
[ 159878-80-5 ]

References: [1]Synthetic Communications,1993,vol. 23,p. 2265 - 2272.

2
[ 5683-31-8 ]
[ 5680-79-5 ]
[ 80050-37-9 ]

References: [1]Journal of Chemical Research, Miniprint,1981,p. 3261 - 3278.

3
[ 5680-79-5 ]
[ 1204-06-4 ]
(E)-N-[3-(1H-indol-3-yl)acryloyl]glycine methyl ester [ No CAS ]

References: [1]Journal of Pharmacy and Pharmacology,2002,vol. 54,p. 295 - 298.

4
[ 51146-57-7 ]
[ 5680-79-5 ]
[(R)-2-(4-Isobutyl-phenyl)-propionylamino]-acetic acid methyl ester [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2005,vol. 48,p. 4312 - 4331.

5
[ 5680-79-5 ]
[ 170642-27-0 ]
[ 900183-91-7 ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 3719 - 3742.

6
[ 69651-48-5 ]
[ 5680-79-5 ]
[ 71448-49-2 ]

References: [1]Journal of the American Chemical Society,2003,vol. 125,p. 1877 - 1887.

7
[ 954147-36-5 ]
[ 5680-79-5 ]
Fmoc-Glu(tetrazole)-Gly-OMe [ No CAS ]

References: [1]Tetrahedron Letters,2007,vol. 48,p. 7038 - 7041.

8
[ 22280-60-0 ]
[ 5680-79-5 ]
C₉H₁₁N₃O₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
74%	With triethylamine; In dimethyl sulfoxide; at 140℃; for 0.5h;Microwave irradiation;	Example-88 (6-Methyl-5-nitro-2-pyridin-2-ylamino)-butionic methyl ester 6-chloro-3-nitro-2-picoline (600 mg, 3.5 mmol) was coupled with glycine methyl ester hydrochloride (880 mg, 7 mmol), triethylamine (1.5 ml, 10.5 mmol) in DMSO 3 mL at 140 °C for 30 min in microwave (Parameters : high absorbance, fixed holding time, pre- stirring 25 seconds). The crude mixture was treated with a saturated aqueous solution of NH4Cl. The aqueous solution of was extracted with EtOAc, washed with water and brine. The crude product was purified on a silica column with CH2Cl2-MeOH as mobile phase. This gave 39 mg (51percent) of 580 mg (74percent) of (6-methyl-5-nitro-2-pyridin-2-ylarcino)- budonic methyl ester as a yellow solid.

References: [1]Patent: WO2005/42464,2005,A1 .Location in patent: Page/Page column 55.

9
[ 102153-63-9 ]
[ 5680-79-5 ]
[ 123090-06-2 ]
methyl N-(6-chloronaphth-2-ylsulphonyl)glycine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine; In dichloromethane;	Elemental Analysis Found C, 56.5; H, 4.8; N, 12.4; C21 H21 ClN4 O3 S requires C, 56.7; H, 4.8; N, 12.6%. The N-(6-chloronaphth-2-ylsulphonyl)glycine used as a starting material was obtained as follows: Triethylamine (0.278 ml) was added to a stirred mixture of 6-chloronaphth-2-ylsulphonyl chloride (0.522 g), glycine methyl ester hydrochloride (0.251 g) and methylene chloride (10 ml) and the mixture was stirred at ambient temperature for 1 hour. The mixture was partitioned between ethyl acetate and water. The organic phase was washed with brine, dried (MgSO4) and evaporated. The residue was recrystallized from methanol to give methyl N-(6-chloronaphth-2-ylsulphonyl)glycine (0.46 g).

References: [1]Patent: US5965559,1999,A .

10
[ 5680-79-5 ]
[ 72040-64-3 ]
C₁₉H₃₂N₄O₅S [ No CAS ]

References: [1]Angewandte Chemie - International Edition,2008,vol. 47,p. 7119 - 7122.

11
[ 5680-79-5 ]
2-methylvinamidinium perchlorate [ No CAS ]
[ 34402-78-3 ]

References: [1]Tetrahedron Letters,2010,vol. 51,p. 4150 - 4152.

12
[ 5680-79-5 ]
[ 7579-20-6 ]
[ 1236525-00-0 ]

Yield	Reaction Conditions	Operation in experiment
66%		Example 1: Synthesis of [l-(l,4-dimethyl-lH-indol-3-ylmethyl)-2,4-dioxo-l,4-dihydro-2H- pyrido[3,4-rf]pyrimidin-3-yl]-acetic acid; To a solution of lOOmg of 3-amino-isonicotinic acid in pyridine (2.5 mL) is added 117 mg of l,l'-carbonyldiimidazole and the mixture is stirred for 20 min at 55 0C. Then the mixture is cooled to room temperature and 91 mg of glycine methylester hydrochloride is added and the resulting mixture is stirred for 30 min at 55 0C and 1 h at room temperature. Then the solvent is removed under vaccum and the residue is purified by flash chromatography on silica gel to give 100 mg (66 percent) of [(3-amino-pyridine-4-carbonyl)-amino]-acetic acid methyl ester.

References: [1]Patent: WO2010/88195,2010,A1 .Location in patent: Page/Page column 23.

13
[ 50-00-0 ]
[ 227023-79-2 ]
[ 1240361-06-1 ]
[ 5680-79-5 ]
C₂₃H₃₃N₃O₆S [ No CAS ]