Home Cart Sign in  
Chemical Structure| 771-50-6 Chemical Structure| 771-50-6
Chemical Structure| 771-50-6

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

Indole-3-carboxylic Acid is a normal urinary indolic tryptophan metabolite with multiple biological roles such as serotonin 5-HT4/6 receptor antagonist, EphB3 receptor tyrosine kinase inhibitor, vinyl ester pseudotripeptide proteasome inhibitor and potential therapeutic agent for Alzheimer′s Disease.

Synonyms: I3CA; ICOOH; β-Indolylcarboxylic Acid

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Product Citations

Anushree Mondal ; Pronay Roy ; Jaclyn Carrannatto ; Prathamesh M. Datar ; Daniel J. DiRocco ; Katherine Huntera and E. Neil G. Marsh

Abstract: The prenylated-flavin mononucleotide-dependent decarboxylases (also known as UbiD-like enzymes) are the most recently discovered family of decarboxylases. The modified flavin facilitates the decarboxylation of unsaturated carboxylic acids through a novel mechanism involving 1,3-dipolar cyclo-addition chemistry. UbiD-like enzymes have attracted considerable interest for biocatalysis applications due to their ability to catalyse (de)carboxylation reactions on a broad range of aromatic substrates at otherwise unreactive carbon centres. There are now ∼35[thin space (1/6-em)]000 protein sequences annotated as hypothetical UbiD-like enzymes. Sequence similarity network analyses of the UbiD protein family suggests that there are likely dozens of distinct decarboxylase enzymes represented within this family. Furthermore, many of the enzymes so far characterized can decarboxylate a broad range of substrates. Here we describe a strategy to identify potential substrates of UbiD-like enzymes based on detecting enzyme-catalysed solvent deuterium exchange into potential substrates. Using ferulic acid decarboxylase (FDC) as a model system, we tested a diverse range of aromatic and heterocyclic molecules for their ability to undergo enzyme-catalysed H/D exchange in deuterated buffer. We found that FDC catalyses H/D exchange, albeit at generally very low levels, into a wide range of small, aromatic molecules that have little resemblance to its physiological substrate. In contrast, the sub-set of aromatic carboxylic acids that are substrates for FDC-catalysed decarboxylation is much smaller. We discuss the implications of these findings for screening uncharacterized UbiD-like enzymes for novel (de)carboxylase activity.

Alternative Products

Product Details of Indole-3-carboxylic acid

CAS No. :771-50-6
Formula : C9H7NO2
M.W : 161.16
SMILES Code : O=C(C1=CNC2=C1C=CC=C2)O
Synonyms :
I3CA; ICOOH; β-Indolylcarboxylic Acid
MDL No. :MFCD00005624
InChI Key :KMAKOBLIOCQGJP-UHFFFAOYSA-N
Pubchem ID :69867

Safety of Indole-3-carboxylic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of Indole-3-carboxylic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 771-50-6 ]
  • Downstream synthetic route of [ 771-50-6 ]

[ 771-50-6 ] Synthesis Path-Upstream   1~3

  • 1
  • [ 771-50-6 ]
  • [ 1670-85-5 ]
References: [1] Helvetica Chimica Acta, 1994, vol. 77, # 7, p. 1886 - 1894.
[2] Phytochemistry, 2000, vol. 53, # 1, p. 59 - 69.
[3] Journal of the Chemical Society, 1956, p. 2853,2856.
[4] Journal of Pharmaceutical and Biomedical Analysis, 2016, vol. 120, p. 419 - 424.
[5] Patent: EP1932833, 2008, A1, .
  • 2
  • [ 771-50-6 ]
  • [ 226883-79-0 ]
References: [1] Pharmazie, 2002, vol. 57, # 4, p. 238 - 242.
  • 3
  • [ 771-50-6 ]
  • [ 868656-97-7 ]
References: [1] Journal of Medicinal Chemistry, 2015, vol. 58, # 24, p. 9768 - 9772.
 

Historical Records

Categories