Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

{[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

Quality Control of 1-Methylindole Purity: 98% SDS Specification

COA

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

NMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

CNMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

HPLC

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

LC-MS

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

1-2 Day Shipping
High Quality
Technical Support

Product Details of 1-Methylindole

CAS No. :	603-76-9
Formula :	C₉H₉N
M.W :	131.17
SMILES Code :	CN1C=CC2=C1C=CC=C2
MDL No. :	MFCD00005800
InChI Key :	BLRHMMGNCXNXJL-UHFFFAOYSA-N
Pubchem ID :	11781

Safety of 1-Methylindole

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of 1-Methylindole

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 603-76-9 ]
Downstream synthetic route of [ 603-76-9 ]

[ 603-76-9 ] Synthesis Path-Upstream 1~3

1
[ 603-76-9 ]
[ 1421372-66-8 ]

Yield	Reaction Conditions	Operation in experiment
90.2%	With potassium hydride In 1,2-dichloro-ethane at 50℃; for 8 h;	2-(4-(N-(2-(dimethylamino)ethyl)-N-methylamino)-2-methoxy-5-amino)-4-chloropyrimidine (5.4g, 15 . 4mmol) and 1 - methyl - 1H - indole (2.6g, 20 . 0mmol) dissolved in 1,2-dichloroethane (100 ml), by adding potassium hydride (1.0g, 24 . 6mmol), the reaction mixture 50 °C stirring reaction for 8 hours, TLC board determine the completion of the reaction, the reaction solution under reduced pressure to dry and concentration, adding ethyl acetate extraction, magnesium sulfate drying, and concentration to dry, ethanol and isopropanol mixed solvent crystallization, 2-(4-(N-(2-(dimethylamino)ethyl)-N-methylamino)-2-methoxy-5-aminophenylamino)-4-(1-methyl-1H-indole-3-yl)pyrimidine, pale yellow solid (6.2g), yield 90.2percent,

References: [1] Patent: CN106543060, 2017, A, . Location in patent: Paragraph 0069; 0070.

2
[ 603-76-9 ]
[ 1421372-66-8 ]

References: [1] Patent: WO2013/14448, 2013, A1, .
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 20, p. 8249 - 8267.
[3] Patent: EP3216786, 2017, A1, .
[4] European Journal of Medicinal Chemistry, 2019, p. 367 - 380.
[5] Patent: CN109280048, 2019, A, .
[6] Patent: CN109134435, 2019, A, .

3
[ 603-76-9 ]
[ 1421373-65-0 ]

References: [1] Patent: WO2013/14448, 2013, A1, .
[2] Patent: WO2013/14448, 2013, A1, .
[3] Patent: WO2013/14448, 2013, A1, .
[4] Journal of Medicinal Chemistry, 2014, vol. 57, # 20, p. 8249 - 8267.
[5] Journal of Chemical Research, 2015, vol. 39, # 6, p. 318 - 320.
[6] Patent: CN109134435, 2019, A, .

[ 603-76-9 ] Synthesis Path-Downstream 1~35

1
[ 603-76-9 ]
[ 21872-75-3 ]
[ 19012-02-3 ]

References: [1]Liebigs Annalen der Chemie,1986,p. 1621 - 1627.

2
[ 603-76-9 ]
[ 108-24-7 ]
[ 19012-02-3 ]

References: [1]Tetrahedron Letters,1995,vol. 36,p. 4005 - 4008.

3
[ 101-06-4 ]
[ 100-61-8 ]
[ 603-76-9 ]

References: [1]Synthetic Communications,1996,vol. 26,p. 1349 - 1353.

4
[ 108-31-6 ]
[ 603-76-9 ]
[ 13031-43-1 ]
Acetic acid 4-((3aR,5R,10bR)-10-methyl-1,3-dioxo-3,3a,4,5,10,10b-hexahydro-1H-2-oxa-10-aza-cyclopenta[a]fluoren-5-yl)-phenyl ester [ No CAS ]

References: [1]Tetrahedron,1996,vol. 52,p. 4555 - 4572.

5
[ 603-76-9 ]
[ 88683-57-2 ]
N-methyl-3-(2-cyanoethyl)thio-1H-indole [ No CAS ]

References: [1]Organic Letters,2006,vol. 8,p. 565 - 568.

6
[ 603-76-9 ]
[ 96-81-1 ]
[ 36993-97-2 ]
2-(2-acetamido-3-methylbutanoyl)-3-(1-methylindol-3-yl)-6-phenyl-3,4-dihydro-2H-[1,2,4]triazin-5-one [ No CAS ]
2-(2-acetamido-3-methylbutanoyl)-3-(1-methylindol-3-yl)-6-phenyl-3,4-dihydro-2H-[1,2,4]triazin-5-one [ No CAS ]

References: [1]Mendeleev Communications,2008,vol. 18,p. 99 - 101.

7
[ 603-76-9 ]
[ 65610-58-4 ]
[ 75-36-5 ]
[ 19012-02-3 ]
[ 65287-75-4 ]
[ 63955-66-8 ]

References: [1]Journal of Organic Chemistry,2010,vol. 75,p. 1047 - 1060.

8
[ 603-76-9 ]
[ 6843-66-9 ]
[ 3558-24-5 ]

References: [1]Organic Letters,2010,vol. 12,p. 3185 - 3187.

9
[ 603-76-9 ]
[ 75-05-8 ]
[ 19012-02-3 ]

Yield	Reaction Conditions	Operation in experiment
41%		General procedure: A 1.5 mL (1.5 mmol) ofPhBCl2 (1.0 mol/L in CH2Cl2) was added to CH2Cl2 solution(4 mL) of the nitrile (5a) (173 mg, 1.2 mmol) at room temperatureunder argon. The mixture was stirred for 15 min. Theindole (1a) (131 mg, 1.0 mmol) was added dropwise to this solutionat room temperature. The resulting solution was stirredfor 3 h, and then 0.5 mol/L Na2CO3 was added to quench thereaction. The resulting mixture was extracted with CH2Cl2.The organic layer was washed with saturated brine, dried(MgSO4), and evaporated. The crude product was purifiedusing silica gel chromatography to provide 3aa (226 mg, 82%yield).

References: [1]Chemistry - A European Journal,2013,vol. 19,p. 1189 - 1193.
[2]Chemical and Pharmaceutical Bulletin,2015,vol. 63,p. 538 - 545.

10
[ 603-76-9 ]
[ 1421373-66-1 ]

References: [1]Patent: WO2013/14448,2013,A1 .
[2]Patent: WO2013/14448,2013,A1 .
[3]Patent: WO2013/14448,2013,A1 .
[4]Journal of Medicinal Chemistry,2014,vol. 57,p. 8249 - 8267.
[5]Patent: CN109134435,2019,A .

11
[ 603-76-9 ]
[ 5424-47-5 ]
[ 1221071-43-7 ]

References: [1]Acta Chimica Slovenica,2013,vol. 60,p. 70 - 80.

12
[ 603-76-9 ]
[ 57772-50-6 ]
C₁₇H₁₈N₂ [ No CAS ]

References: [1]Advanced Synthesis and Catalysis,2013,vol. 355,p. 1483 - 1489.

13
[ 603-76-9 ]
[ 37585-16-3 ]
C₁₆H₁₅ClN₂ [ No CAS ]

References: [1]Advanced Synthesis and Catalysis,2013,vol. 355,p. 1483 - 1489.

14
[ 603-76-9 ]
[ 802919-90-0 ]
[ 1421521-19-8 ]
[ 1609470-76-9 ]
[ 1609470-58-7 ]