2,5-Dimethylpyrazine | NSC 49139 | Pyrazines

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Quality Control of 2,5-Dimethylpyrazine Purity: 97% SDS Specification

COA

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NMR

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CNMR

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HPLC

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Product Details of 2,5-Dimethylpyrazine

CAS No. :	123-32-0
Formula :	C₆H₈N₂
M.W :	108.14
SMILES Code :	C1=NC(=CN=C1C)C
Synonyms :	NSC 49139
MDL No. :	MFCD00006147
InChI Key :	LCZUOKDVTBMCMX-UHFFFAOYSA-N
Pubchem ID :	31252

Safety of 2,5-Dimethylpyrazine

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of 2,5-Dimethylpyrazine

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 123-32-0 ]
Downstream synthetic route of [ 123-32-0 ]

[ 123-32-0 ] Synthesis Path-Upstream 1~2

1
[ 78-90-0 ]
[ 56-81-5 ]
[ 123-32-0 ]
[ 108-50-9 ]
[ 77164-93-3 ]

References: [1] Chinese Chemical Letters, 2013, vol. 24, # 8, p. 751 - 754.

2
[ 78-90-0 ]
[ 56-81-5 ]
[ 123-32-0 ]
[ 61892-95-3 ]
[ 108-50-9 ]
[ 77164-93-3 ]

References: [1] Chinese Chemical Letters, 2013, vol. 24, # 8, p. 751 - 754.

[ 123-32-0 ] Synthesis Path-Downstream 1~33

1
[ 123-32-0 ]
[ 13134-38-8 ]

Yield	Reaction Conditions	Operation in experiment
10%	With sodium amide; In N,N-dimethyl-aniline; at 170℃; for 1h;	(b) 3,6-Dimethylpyrazin-2-amine A mixture of 2,5-dimethylpyrazine (14 g, 0.13 mol) in N,N-dimethylaniline (50 mL) was heated to 170 C. and NaNH2 (22 g, 0.56 mol) was added in portions. The reaction mixture was stirred at 170 C. for 1 h, and the solvent was removed. The product was purified by silica gel column chromatography to give 3,6-dimethylpyrazin-2-amine as a brown solid (1.6 g, yield 10%). ESI MS: m/z 124 [M+1]+.
	With sodium amide; N,N-dimethyl-aniline; at 170℃;	(b) 3,6-Dimethylpyrazin-2-amine[00426] A mixture of 2,5-dimethylpyrazine (14 g, 0.13 mol) in N,N-dimethylaniline (50 mL) was heated to 170 C and NaNH2 (22 g, 0.56 mol) was added in portions. The reaction mixture was stirred at 170 C for 1 h, and the solvent was removed. The product was purified by column chromatography to give 3,6-dimethylpyrazin-2-amine as a brown solid (1.6 g). MS (ESI): m/z 124[M+H]+.

References: [1]Patent: US2012/178748,2012,A1 .Location in patent: Page/Page column 41.
[2]Zhurnal Russkago Fiziko-Khimicheskago Obshchestva,1930,vol. 62,p. 1189,1193.
Chemisches Zentralblatt,1930,vol. 101,p. 3771.
[3]Journal of the American Chemical Society,1941,vol. 63,p. 1929.
[4]Patent: WO2011/150156,2011,A2 .Location in patent: Page/Page column 122.

2
[ 123-32-0 ]
[ 77666-94-5 ]
[ 50866-30-3 ]
[ 5780-66-5 ]

References: [1]Chemistry of Heterocyclic Compounds,1986,vol. 22,p. 915 - 917.
Khimiya Geterotsiklicheskikh Soedinenii,1986,p. 1124 - 1126.
[2]Chemistry of Heterocyclic Compounds,1986,vol. 22,p. 915 - 917.
Khimiya Geterotsiklicheskikh Soedinenii,1986,p. 1124 - 1126.

3
[ 930-61-0 ]
[ 67-66-3 ]
[ 14331-54-5 ]
[ 123-32-0 ]
[ 54198-89-9 ]
[ 4472-45-1 ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1980,p. 1431 - 1435.

4
[ 930-61-0 ]
[ 67-66-3 ]
[ 14331-54-5 ]
[ 123-32-0 ]
[ 95-89-6 ]
[ 38557-72-1 ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1980,p. 1431 - 1435.

5
[ 930-61-0 ]
[ 67-66-3 ]
[ 123-32-0 ]
[ 95-89-6 ]
[ 38557-72-1 ]
[ 75712-74-2 ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1980,p. 1431 - 1435.

6
[ 123-84-2 ]
[ 290-37-9 ]
[ 109-08-0 ]
[ 123-32-0 ]
[ 13925-00-3 ]
[ 693-98-1 ]
[ 15707-23-0 ]

References: [1]Chemistry of Heterocyclic Compounds,1993,vol. 29,p. 1308 - 1315.
Khimiya Geterotsiklicheskikh Soedinenii,1993,p. 1516 - 1525.

7
[ 134276-45-2 ]
[ 78-98-8 ]
[ 109-08-0 ]
[ 123-32-0 ]
[ 5910-89-4 ]
[ 13360-65-1 ]
[ 108-50-9 ]
[ 55138-74-4 ]
[ 14667-55-1 ]
[ 80935-98-4 ]
[ 13925-07-0 ]
[ 15707-34-3 ]