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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 294-90-6 Chemical Structure| 294-90-6

Structure of Cyclen
CAS No.: 294-90-6

Chemical Structure| 294-90-6

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Cyclen compounds are capable of selectively binding cations and used as a ligand in chemistry for instance with chemicals used in MRI contrast agents.

4.5 *For Research Use Only !

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Product Citations

Product Citations      Show More

Tang, Jian-Hong ; Luo, Minrui ; Tsao, Wilhelmina ; Waters, Emily Alexandria ; Parigi, Giacomo ; Luchinat, Claudio , et al.

Abstract: Glycoconjugates forming from the conjugation of carbohydrates to other biomolecules, such as proteins, lipids, or other carbohydrates, are essential components of mammalian cells and are involved in numerous biological processes. Due to the capability of sugars to form multiple hydrogen bonds, many synthetic glycoconjugates are desirable biocompatible platforms for imaging, diagnostics, drugs, and supramolecular self-assemblies. Herein, we present a multimeric galactose functionalized paramagnetic gadolinium (Gd(III)) chelate that displays spontaneous dynamic aggregation in aqueous conditions. The dynamic aggregation of the Gd(III) complex was shown by the concentration-dependent magnetic resonance (MR) relaxation measurements, nuclear magnetic resonance dispersion (NMRD) analysis, and dynamic light scattering (DLS). Notably, these data showed a nonlinear relationship between magnetic resonance relaxation rate and concentrations (0.03−1.35 mM), and a large DLS hydrodynamic radius was observed in the high-concentration solutions. MR phantom images were acquired to visualize real-time dynamic aggregation behaviors in aqueous solutions. The in situ visualization of the dynamic self-assembling process of multivalent glycoconjugates has rarely been reported.

Purchased from AmBeed: ; ;

Li, Bowen ; Manan, Rajith Singh ; Liang, Shun-Qing ; Gordon, Akiva ; Jiang, Allen ; Varley, Andrew , et al.

Abstract: The expanding applications of nonviral genomic medicines in the lung remain restricted by delivery challenges. Here, leveraging a high-throughput platform, we synthesize and screen a combinatorial library of biodegradable ionizable lipids to build inhalable delivery vehicles for mRNA and CRISPR-Cas9 gene editors. Lead lipid nanoparticles are amenable for repeated intratracheal dosing and could achieve efficient gene editing in lung epithelium, providing avenues for gene therapy of congenital lung diseases.

Alternative Products

Product Details of Cyclen

CAS No. :294-90-6
Formula : C8H20N4
M.W : 172.27
SMILES Code : C1CNCCNCCNCCN1
MDL No. :MFCD00066281

Safety of Cyclen

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302+H312-H314-H410
Precautionary Statements:P501-P273-P260-P270-P264-P280-P391-P362+P364-P303+P361+P353-P301+P330+P331-P301+P312+P330-P304+P340+P310-P305+P351+P338+P310-P405
Class:8
UN#:3259
Packing Group:

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

5.80mL

1.16mL

0.58mL

29.02mL

5.80mL

2.90mL

58.05mL

11.61mL

5.80mL

 

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