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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Benzyl Alcohol is a monoaromatic primary alcohol widely used as a solvent and as an intermediate in cosmetic formulations, pharmaceutical and flavor/fragrance industries.
Synonyms: Benzenemethanol
4.5
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Batch number can be found on the product's label following the word 'Batch'.
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Joanna Klimek ; Oskar Kruc ; Joanna Ceklarz ; Beata Kami ´nska ; Bogdan Musielak ; Robin van der Straat , et al.
Abstract: The PD-1/PD-L1 complex is an immune checkpoint responsible for regulating the natural immune response, but also allows tumors to escape immune surveillance. Inhibition of the PD-1/PD-L1 axis positively contributes to the efficacy of cancer treatment. The only available therapeutics targeting PD-1/PD-L1 are monoclonal antibody-based drugs, which have several limitations. Therefore, small molecule compounds are emerging as an attractive alternative that can potentially overcome the drawbacks of mAb-based therapy. In this article, we present a novel class of small molecule compounds based on the terphenyl scaffold that bind to PD-L1. The general architecture of the presented structures is characterized by axial symmetry and consists of three elements: an m-terphenyl core, an additional aromatic ring, and a solubilizing agent. Using molecular docking, we designed a series of final compounds, which were subsequently synthesized and tested in HTRF assay and NMR binding assay to evaluate their activity. In addition, we performed an in-depth analysis of the mutual arrangement of the phenyl rings of the terphenyl core within the binding pocket of PD-L1 and found several correlations between the plane angle values and the affinity of the compounds towards the protein.
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Keywords: PD-L1 ; immune checkpoint ; small molecule inhibitor ; cancer ; C2-symmetrical ligands
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Surveying the scope of aromatic decarboxylations catalyzed by prenylated-flavin dependent enzymes
Anushree Mondal ; Pronay Roy ; Jaclyn Carrannatto ; Prathamesh M. Datar ; Daniel J. DiRocco ; Katherine Huntera and E. Neil G. Marsh
Abstract: The prenylated-flavin mononucleotide-dependent decarboxylases (also known as UbiD-like enzymes) are the most recently discovered family of decarboxylases. The modified flavin facilitates the decarboxylation of unsaturated carboxylic acids through a novel mechanism involving 1,3-dipolar cyclo-addition chemistry. UbiD-like enzymes have attracted considerable interest for biocatalysis applications due to their ability to catalyse (de)carboxylation reactions on a broad range of aromatic substrates at otherwise unreactive carbon centres. There are now ∼35[thin space (1/6-em)]000 protein sequences annotated as hypothetical UbiD-like enzymes. Sequence similarity network analyses of the UbiD protein family suggests that there are likely dozens of distinct decarboxylase enzymes represented within this family. Furthermore, many of the enzymes so far characterized can decarboxylate a broad range of substrates. Here we describe a strategy to identify potential substrates of UbiD-like enzymes based on detecting enzyme-catalysed solvent deuterium exchange into potential substrates. Using ferulic acid decarboxylase (FDC) as a model system, we tested a diverse range of aromatic and heterocyclic molecules for their ability to undergo enzyme-catalysed H/D exchange in deuterated buffer. We found that FDC catalyses H/D exchange, albeit at generally very low levels, into a wide range of small, aromatic molecules that have little resemblance to its physiological substrate. In contrast, the sub-set of aromatic carboxylic acids that are substrates for FDC-catalysed decarboxylation is much smaller. We discuss the implications of these findings for screening uncharacterized UbiD-like enzymes for novel (de)carboxylase activity.
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Purchased from AmBeed: 27916-43-4 ; 2438-05-3 ; 501-89-3 ; 42287-94-5 ; 776-79-4 ; 53473-36-2 ; 7251-61-8 ; 42287-97-8 ; 1621-91-6 ; 37718-11-9 ; 288-13-1 ; 86-73-7 ; 104-53-0 ; 2018-90-8 ; 87-66-1 ; 135-19-3 ; 1664-57-9 ; 289-80-5 ; 693-95-8 ; 55-22-1 ; 102-93-2 ; 1477-50-5 ; 1632-76-4 ; 4780-79-4 ; 16642-79-8 ; 3581-89-3 ; 501-97-3 ; 771-50-6 ; 98-98-6 ; 619-64-7 ; 100-51-6 ; 402-45-9 ; 59-67-6 ; 93-60-7 ; 273-53-0 ; 2084-13-1 ; 51-17-2 ; 2459-09-8 ; 2459-07-6 ; 95-16-9 ; 459-31-4 ; 90-05-1 ; 150-76-5 ; 103-25-3 ; 271-44-3 ; 6293-56-7 ; 2550-26-7 ; 288-32-4 ; 501-52-0 ; 2001-32-3 ; 1592-38-7 ; 95-15-8 ; 91-19-0 ; 1122-61-8 ; 3724-19-4 ; 20173-24-4 ; 118-31-0 ; 6125-24-2 ; 60-12-8 ; 90-15-3 ; 120-72-9 ; 822-36-6 ; 288-47-1 ; 288-42-6 ; 2038-57-5 ; 38628-51-2 ; 1929-29-9 ; 15009-91-3 ; 1505-50-6 ; 581-40-8 ; 616-47-7 ; 1571-33-1
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CAS No. : | 100-51-6 |
Formula : | C7H8O |
M.W : | 108.14 |
SMILES Code : | OCC1=CC=CC=C1 |
Synonyms : |
Benzenemethanol
|
MDL No. : | MFCD00004599 |
InChI Key : | WVDDGKGOMKODPV-UHFFFAOYSA-N |
Pubchem ID : | 244 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
89% | Stage #1: With sodium hydride In N,N-dimethyl-formamide; mineral oil at 5℃; for 0.25 h; Stage #2: at 5 - 60℃; |
A flask is charged with NaH (60percent dispersion in mineral oil, 0.72 g, 18.0 mmol) then suspended in DMF (30 mL) and cooled to 5° C. To this mixture is added benzyl alcohol (1.04 mL, 10.0 mmol) drop-wise. The mixture is stirred for 15 minutes then 4-chloropyridine-HCl (1.00 g, 6.67 mmol) is added in three portions over 5 min. The resulting mixture is stirred at 5° C. for 10 min then warmed to 60° C. and stirred for 1.5 h. The mixture is then cooled to 23° C., treated with water, and extracted with EtOAc. The combined organics are dried with MgSO4, filtered, and concentrated in vacuo. Purification of the crude by flash chromatography (SiO2, 5percent EtOAc in hexanes to 50percent EtOAc in hexanes) gives the title intermediate (1.10 g, 89percent). |
89% | Stage #1: With sodium hydride In N,N-dimethyl-formamide; mineral oil at 5℃; for 0.25 h; Stage #2: at 5 - 60℃; for 1.75 h; |
Example 3 Synthesis of 4-(benzyloxy)pyridine. A flask is charged with NaH (60percent dispersion in mineral oil, 0.72 g, 18.0 mmol) then suspended in DMF (30 mL) and cooled to 5 °C. To this mixture is added benzyl alcohol (1.04 mL, 10.0 mmol) drop-wise. The mixture is stirred for 15 minutes then 4-chloropyridine-HCl (1.00 g, 6.67 mmol) is added in three portions over 5 min. The resulting mixture is stirred at 5 °C for 10 min then warmed to 60 °C and stirred for 1.5 h. The mixture is then cooled to 23 °C, treated with water, and extracted with EtOAc. The combined organics are dried with MgSO4, filtered, and concentrated in vacuo. Purification of the crude by flash chromatography (SiO2, 5percent EtOAc in hexanes to 50percent EtOAc in hexanes) gives the title intermediate (1.10 g, 89percent). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
98% | toluene-4-sulfonic acid; In toluene;Reflux; | 10 g (0.037 moles) of 6,11-dihydro-11-oxodibenz[b,e] oxepin-2-acetic acid were dissolved in 100 ml of toluene and 2 g (0.01 moles) of p-toluenesulfonic acid (p-TsOH) and 17.5 ml (0.169 moles) of benzyl alcohol were added to this solution. The reaction was equipped with a Dean-Stark, a mixture of water/toluene thus being distilled. The reaction was maintained until 0.7 ml of water were collected. The reaction was left to cool to 20-25°C, at which temperature 1.5 ml (0.011 moles) of Et3N were added. The resulting solution was concentrated under reduced pressure until obtaining a residue which was dissolved in isopropanol (50 ml), giving rise to a suspension. The obtained suspension was stirred at 20-25°C for 30 minutes, then being cooled at 0-5°C. Stirring was maintained at this temperature for 30 minutes. Then, the suspension was filtered and washed, obtaining 12.5 g (0.036 moles, 98percent) of a white solid identified as the compound of the title, the spectroscopic properties of which are: 1H-NMR (CDCl3, 400 MHz), delta: 3.70 (s, 2H); 5.14 (m, 4H), 7.02 (d, 1H), 7.33 (m, 1H); 7.41-7.46 (m, 4H), 7.52 (m, 3H); 7.88 (m, 2H); 8.15 (d, 1H) ppm. 13C-NMR (CDCl3, 400 MHz), delta: 39.95; 66.56; 73.37; 120.88; 124.92; 127.48; 127.64; 128.04 (2); 128.10; 128.39 (2); 129.05; 129.25; 132.32; 132.58; 135.33;135.53; 136.20; 140.60; 160.72; 171.48; 191.01. MS, M++1: 358.12. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
89% | With potassium hydroxide; In toluene; at 90℃; for 20h; | General procedure: To an oven-dried 20 cm3 test tube with a ground-in stopperequipped with a stir bar were added anthranilamide (1.0 mmol), benzyl alcohol (1.0 mmol), KOH (2.0 mmol),and 4 cm3 toluene. The test tube was put in an oil bath potpreheated at 90 C and the mixture was stirred for 20 h at90 C. After cooling to room temperature, the reactionmixture was added about 5 g silica gel and directly condensedon a rotator under vacuum. The resulting residualwas transferred to a silica gel chromatography column andeluted with a solution of petroleum ether and ethyl acetate[4/1 (v/v)] to give a white solid 2-phenyl-4(3H)-quinazolinone.For some products (3f, 3g, 3n, and 3t) onlysparingly soluble in ethyl acetate, the reaction mixtureswere condensed in vacuo on a rotary evaporator. Theresiduals were washed three times with water and oncewith ethyl acetate, and then dried in an infrared oven togive the desired products pure enough for NMR analysis. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With pyridine; p-toluenesulfonyl chloride; In toluene; at 0 - 20℃; for 2.0h; | To a stirred solution of <strong>[16176-74-2]2-(1H-indol-4-yl)acetic acid</strong> 45 (11.0 g, 62.9 mmol) in pyridine (45 mL) were added benzyl alcohol (6.9 mL, 66.0 mmol) and a solution of p-toluenesulfonyl chloride (13.2 g, 69.2 mmol) in toluene (38 mL) at 0 °C. After stirring vigorously for 2 h at room temperature, the reaction mixture was diluted with water and extracted with MTBE (.x.2). The combined organic layers were washed with NaHCO3 aq, water and brine, dried over Na2SO4 and concentrated in vacuo to give 46 as a dark brown oil, which was used for the next reaction without further purification; TLC Rf = 0.45 (n-hexane/EtOAc, 2:1). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | With sodium sulfide hydrate; iron(III) chloride hexahydrate; at 150℃; for 24h;Inert atmosphere; | General procedure: A 20-mL test-tube equipped with a magnetic stirring bar was charged with o-nitroaniline 1 (2.5 mmol, 1 equiv), alcohol 2 or 5 (3 mmol, 1.2equiv), Na2S·nH2O (?60percent, 130 mg, 1 mmol, 40 molpercent) and FeCl3·6H2O(7 mg, 0.025 mmol, 1 molpercent). The resulting mixture was stirred for 24h under an argon atmosphere at the indicated temperature (see Schemes 2 and 3 and Table 2). After cooling to r.t., the mixture was purified in different ways. (i) For NH benzimidazole products, the mixture was washed with CH2Cl2 (3 × 2 mL) then dissolved in MeOH.The MeOH solution was filtered through a short pad of silica gel. The filtrate was concentrated in vacuo to afford the NH benzimidazole product. Further purification by column or recrystallization was carried out if necessary. (ii) For N-methyl-2-phenylbenzimidazole 3ha and quinoxalines 5, the crude mixture was dissolved in a minimum volume of CH2Cl2 and purified by column chromatography (silica gel or alumina, heptane?EtOAc, EtOAc, EtOAc?MeOH, hexane?Et2O). We noted that some 13C NMR signals of NH-benzimidazoles are missing or difficult to observe. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
79% | With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; caesium carbonate; In tert-Amyl alcohol; at 120℃; for 12h;Inert atmosphere; Schlenk technique; | <strong>[6973-09-7]5-amino-2-methylbenzenesulfonamide</strong> (186 mg, 1 mmol), [Cp * IrCl2] 2 (8 mg, 0.01(10 mgpercent), cesium carbonate (65 mg, 0.2 mmol), benzyl alcohol (130 mg, 1.2 mmol), t-amyl alcohol (1.0ML) were sequentially added to a 25 mL Schlenk reaction flask. The mixture was allowed to react at 120 ° C for 12 hours and then cooledThe solvent was removed under vacuum at room temperature. And then purified by column chromatography (developing solvent: ethyl acetate / n-hexane)Net target compound, yield: 79percent |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
55% | With CBV600; at 110℃; for 0.0583333h;Microwave irradiation; Sealed tube; | 10236] A mixture of 3.3 mmol of <strong>[3027-21-2]methylphenyldi(methoxy)silane</strong> (Ia), 13.3 mmol of benzyl alcohol (hg) and 10mg of CBV 600 (by Zeolyst International) was charged into a reaction tube that was then sealed, with stirring for 3.5 minutes at 110° C., using a microwave irradiation device (Initiator by Biotage AB). The resulting product was post-processed and distilled in the same way as in Example 101. As a result there were obtained 1.8 mmol (yield 55percent) of methylphenyl(methoxy)(benzyloxy)silane (lilt-i).10237] The physical property values, spectral data and so forth of (lilt-i) were as follows.10238] Boiling point: 105-i 10° C./0.35 mmHg (distillation temperature in short-path distillation)10239] Element analysis: C, 69.52; H, 7.04 (measured value); C, 69.72; H, 7.02 (calculated value C15H18O2Si);j0240] ?H-NMR (CDC13): oe 0.39 (s, 3H, SiCH3), 3.52 (s, 3H, OCH3), 4.83 (s, 1H, OCHCHb), 4.86 (s, 1H, OCHCHb),7.23-7.28 (m, 1H, aromatic ring H), 7.32-7.45 (m, 7H, aromatic ring H), 7.64-7.67 (m, 2H, aromatic ring H)j0241] ?3C-NMR (CDC13): oe ?4.6,50.6,64.7, 126.6, 127.2, 127.9, 128.3, 130.2, 133.9, 134.1, 140.4j0242] 29Si-NMR (CDC13): oe ?15.010243] IR (liquid film): 1592, 1496, 1454, 1429, 1379, 1259,1208,1190,1121,1086, 1028,853,809,777,738,698, 659, 581, 482, 438 cm?j0244] GC-MS (El, 70 eV): mlz (relative intensity) 258 (M, 3.2), 225 (12), 213 (27), 211 (28), 180 (59), 165 (32), 151 (14), 121 (17), 91(100), 65 (17), 59 (ii) |
55% | With CBV 600; at 110℃; for 0.0583333h;Sealed tube; Microwave irradiation; | Di(methoxy)(methyl)(phenyl)silane (IIIa) 3.3mmol, benzyl alcohol (IVr) 13.3mmol, CBV600 (Zeolyst Co., Ltd.) 10 mg of mixture into the reaction tube is sealed, a microwave irradiation device using a (Biotage made Initiator), 3.5 minutes at 110 °C by stirring. With a centrifugal separator for separating solid catalyst, after the supernatant liquid is separated, washed with catalyst (2 times at 0.8 ml) hexane, and cleaning of the supernatant liquid concentrated under reduced pressure, as a result of the short path is distilled in a distillation device, (methoxy)(benzyloxyimino)(methyl) (phenyl)silane (Vak-1 (Iak-1)) is, obtd. 1.8mmol (yield 55percent). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With CBV600; at 110℃; for 0.0833333h;Microwave irradiation; | 10096] A mixture of 1.65 mmol of <strong>[3027-21-2]methylphenyldi(methoxy)silane</strong> (Ia), 6.6 mmol of butanol (ha) and 5 mg of CBV 780 (by Zeolyst International) was charged into a reaction tube, with stirring for 1 minute at room temperature (23° C.). The resulting product was analyzed using a gas chromatograph and a gas chromatographlmass spectrometer. The results revealed that a mixture of butoxysilane (lila) (lila-i:methylphenyl(methoxy)(butoxy)silane and IIIa-2: methylphenyldi(butoxy)silane, lila-i :IIIa-2=90: 10) had been generated with a yield of 88.5percent (see Table 1).10097] Reactions and analyses were carried out in the sameway as in Example 1, but modi1,?ing reaction conditions(starting materials, catalysts, temperature, time and so forth).The results of measurements of product yields are given inTable 1. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
85% | With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In dichloromethane; for 12h; | Intermediate 347<strong>[3471-31-6]2-<strong>[3471-31-6](5-methoxy-1H-indol-3-yl)acetic acid</strong></strong> (5 g, 24.4 mmol) and BOP-Cl (7.4 g, 29 mmol) were suspended in DCM (100 mL), and Et3N (5.4 g, 53.7 mmol) was slowly added. The resulting solution was stirred for 30 min. Benzyl alcohol (2.9 g, 26.8 mmol) was added and the mixture was stirred for 12 h. DCM (100 mL) was added, the layers were separated and the organic layer was washed with water (200 mL) and brine. The organic layer was concentrated and purified by chromatography on silica gel (eluent: PE/EtOAc=2/1) to give 347 as a white solid (6.1 g, 85percent). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
3.1 g | With sodium hydride; In 1-methyl-pyrrolidin-2-one; at 20℃; for 5h;Cooling with ice; | 2.3 g of benzyl alcohol was added under ice-cooling to a mixture of 3.0 g of <strong>[19745-07-4]2,5-dichloropyrazine</strong>, 880 mg of sodium hydride (60percent, oil) and 50 mL of NMP.The reaction mixture was warmed to room temperature and stirred at room temperature for 5 hours.Water was added to the obtained reaction mixture, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure.The obtained residue was subjected to silica gel chromatography to obtain 3.1 g of Intermediate 1 represented by the following formula. |
3.1 g | With sodium hydride; In 1-methyl-pyrrolidin-2-one; mineral oil; at 20℃; for 5h;Cooling with ice; | 3.0 g of <strong>[19745-07-4]2,5-dichloropyrazine</strong>,880 mg of sodium hydride (60percent, oil)And 50 mL of NMP,2.3 g of benzyl alcohol was added under ice cooling.The reaction mixture was allowed to warm to room temperature and stirred at room temperature for 5 hours.Water was added to the resulting reaction mixture, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed with saturated brine, dried over anhydrous sodium sulfate,And concentrated under reduced pressure. The obtained residue was subjected to silica gel chromatography,3.1 g of Intermediate 1 represented by the following formula was obtained.Intermediate 1 |
3.1 g | With sodium hydride; In 1-methyl-pyrrolidin-2-one; mineral oil; at 20℃; for 5h;Cooling with ice; | A mixture of <strong>[19745-07-4]2,5-dichloropyrazine</strong> 3.0 g, sodium hydride (60percent, oil) 880 ml, and NMP 50 ml was added to 2.3 g of benzyl alcohol under ice-cooling. The reaction mixture was warmed to room temperature and stirred at room temperature for 5 hours. The resulting reaction mixture was added with water and extracted with ethyl acetate. The resulting organic layer was washed with saturated brine, dried over sodium sulfate, concentrated under reduced pressure, and the resulting residue was subjected to silica gel column chromatography to give 3. lg of an intermediate of the following formula 1 . |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | With benzyl bromide; at 130℃; for 12h;Green chemistry; | <strong>[4214-79-3]2-hydroxy-5-chloropyridine</strong> (0.259 g, 2 mmol), benzyl alcohol (2.4 mmol,1.2 equiv.) And benzyl bromide (0.0475 ml, 20 molpercent)were added successively to the tube reactor, And then heatedto 130 ° C for 12 hunder solvent-free conditions.After the TLC monitoring reaction was complete, the product was purified by column chromatography and the yield was 90percent. |
Tags: Benzyl alcohol | Benzenemethanol | Aryls | Alcohols | Organic Building Blocks | 100-51-6
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P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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