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Chemical Structure| 4530-20-5 Chemical Structure| 4530-20-5
Chemical Structure| 4530-20-5

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Boc-Gly-OH is a glycine derivative, mainly used for peptide synthesis and as an important intermediate for various drugs and biotechnological applications.

Synonyms: N-tert-Butoxycarbonyl-2-aminoacetic acid; NSC 127669; Boc-Glycine

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Product Citations

Product Citations

Rathje, Oliver H. ; Perryman, Lara ; Payne, Richard J. ; Hamprecht, Dieter W. ;

Abstract: Mixed Lineage Kinase domain-Like pseudokinase (MLKL) is implicated in a broad range of diseases due to its role as the ultimate effector of necroptosis and has therefore emerged as an attractive drug target. Here, we describe the development of PROteolysis TArgeting Chimeras (PROTACs) as a novel approach to knock down MLKL through chem. means. A series of candidate degraders were synthesized from a high-affinity pyrazole carboxamide-based MLKL ligand leading to the identification of a PROTAC mol. that effectively degraded MLKL and completely abrogated cell death in a TSZ model of necroptosis. By leveraging the innate ability of these PROTACs to degrade MLKL in a dose-dependent manner, the quant. relationship between MLKL levels and necroptosis was interrogated. This work demonstrates the feasibility of targeting MLKL using a PROTAC approach and provides a powerful tool to further our understanding of the role of MLKL within the necroptotic pathway.

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Product Details of Boc-Gly-OH

CAS No. :4530-20-5
Formula : C7H13NO4
M.W : 175.18
SMILES Code : O=C(O)CNC(OC(C)(C)C)=O
Synonyms :
N-tert-Butoxycarbonyl-2-aminoacetic acid; NSC 127669; Boc-Glycine
MDL No. :MFCD00002690
InChI Key :VRPJIFMKZZEXLR-UHFFFAOYSA-N
Pubchem ID :78288

Safety of Boc-Gly-OH

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H318
Precautionary Statements:P280-P305+P351+P338-P310-P403-P501

Application In Synthesis of Boc-Gly-OH

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 4530-20-5 ]
  • Downstream synthetic route of [ 4530-20-5 ]

[ 4530-20-5 ] Synthesis Path-Upstream   1~3

  • 1
  • [ 4530-20-5 ]
  • [ 74-88-4 ]
  • [ 42492-57-9 ]
References: [1] Chemistry - A European Journal, 2010, vol. 16, # 39, p. 11954 - 11962.
[2] Journal of Natural Products, 2003, vol. 66, # 2, p. 183 - 199.
  • 2
  • [ 4530-20-5 ]
  • [ 174799-52-1 ]
References: [1] Journal of Organic Chemistry, 1998, vol. 63, # 12, p. 4131 - 4134.
  • 3
  • [ 4530-20-5 ]
  • [ 142121-48-0 ]
References: [1] Tetrahedron Letters, 1988, vol. 29, # 11, p. 1265 - 1268.
 

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